Protein Alignment GluRIA and Grik3

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 953
• Identity: 311/953 - (32%)
• Similarity: 507/953 - (53%)
• Gaps: 137/953 - (14%)

  Fly     4 RLKFLAYLHF----ICASSIFW-PEFSSAQQQQQTVSLTEKIPLGAIFE-------QGTDDVQSA 56
            ||:.|.:.::    :||   || |:         :..:...|.:|.|||       |..:..:.|
Mouse     7 RLRSLVWEYWAGFLVCA---FWIPD---------SRGMPHVIRIGGIFEYADGPNAQVMNAEEHA 59

  Fly    57 FKYA--MLNHN---LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT 116
            |:::  ::|.|   |..::..:::|.    |:..|:|:.::..|:|.:.||.::.|.......:.
Mouse    60 FRFSANIINRNRTLLPNTTLTYDIQR----IHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA 120

  Fly   117 LHSYSNTFQMPFV-TPWFPEKVLAPSSGLLDFAISMRPDY---HQAIIDTIQYYGWQSIIYLYDS 177
            :.|..|..::|.: ..|...    |......|.:::.|||   ..||:|.:|...|:|...:||.
Mouse   121 VQSICNALEVPHIQLRWKHH----PLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDD 181

  Fly   178 HDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEI 242
            ..||:|||::.......|...:::.:...::.:..:     |:::.|..:.||:.||...||.:|
Mouse   182 STGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPL-----LKEMKRGREFRIIFDCSHTMAAQI 241

  Fly   243 IVQHVRDIKLGRRT--YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHD-- 300
            :.|   .:.:|..|  ||::.:.|   .:|    .:...:..:|:|||||::.:...|....:
Mouse   242 LKQ---AMAMGMMTEYYHFIFTTLDLYALD----LEPYRYSGVNLTGFRILNVDNPHVSAIVEKW 299

  Fly   301 SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHG 365
            :.:||:.:.:::|....|     .:...|||:||||.::...:.|     ..|...|.||
Mouse   300 AMERLQAAPRAESGLLDG-----VMMTDAALLYDAVHIVSVCYQR-----APQMTVNSLQ----- 349

  Fly   366 GSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTL 429
                              |:..|.    |..|.:....:::.:.:||:|.|.|:: .|.|.::.|
Mouse   350 ------------------CHRHKA----WRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL 392

  Fly   430 HVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLK 494
            .::.:..:. |::|..|....||      |....::....:..|...|.:.||:::||||::..:
Mouse   393 DIISLKEDG-LEKVGVWSPADGL------NITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFR 450

  Fly   495 QYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKE 559
            :  ...:|.|||||||||.||...||..||..||||||:||.|||::.  .|.|:|||.|||..:
Mouse   451 K--SDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD--KGQWNGMVKELIDHK 511

  Fly   560 ADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGV 624
            ||:|::.:|||..||:.|||||||||||:||:.:||....|.|||||||||.:||:.|:|:|:||
Mouse   512 ADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGV 576

  Fly   625 SFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLA 689
            |.||:.:.||.||||       .|:....|     |:.:.|          |.||:|||||:.:.
Mouse   577 SCVLFVIARFSPYEW-------YDAHPCNP-----GSEVVE----------NNFTLLNSFWFGMG 619

  Fly   690 AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNY 754
            :.||||.::.|.:::.||...:|||||:|:|||||||||||||||||.:||.:.:||..||.:.|
Mouse   620 SLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY 684

  Fly   755 GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN 819
            |.:..|:|..||::|:|....|||.:|::.....|...:|||:|...:  .||||:||...||:.
Mouse   685 GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTA--DYALLMESTTIEYIT 747

  Fly   820 ARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQE 884
            .| .|:..::|..||:||:|:.||:|||.|.::..|:|.|:|..:|..::.||| ..:.|. ::|
Mouse   748 QR-NCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW-RGSGCP-EEE 809

  Fly   885 TSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCR-NKTPQ 926
            ....:.|.:..:.||:.:|..||:|:|:||:.||..: .||.:
Mouse   810 NKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAE 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	98/438 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	186/401 (46%)
		Lig_chan	610..906	CDD:459656	118/295 (40%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	99/443 (22%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	186/397 (47%)