DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grik1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	950	Identity:	325/950 - (34%)
Similarity:	513/950 - (54%)	Gaps:	146/950 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFE----QGTDDVQSAFKYAMLNHNLN---- 67
            |:|:|   ...|:.|           .:.:.:|.|||    :..:..:.|||:|:.:.|.|
Mouse    22 LYFLC---YILPQTS-----------PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLM 72

  Fly    68 -VSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-T 130
             .::..:::|.    ||..|:|:.||..|:|.:.||.::.|.....|...:.|..|..::|.: |
Mouse    73 PNTTLTYDIQR----INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133

  Fly   131 PWFPEKVLAPSSGLLD-FAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQEL 191
            .|     ..||....| |.|::.|||   .:|::|.:.||.|:::..:|:...||:|||::.:
Mouse   134 RW-----KHPSVDNRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIK-- 191

  Fly   192 KPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT 256
            .|.....::: ::::.:.....:.|  |:::.:..:..::.||..|.|.||:.|   .:.:|..|
Mouse   192 APSRYNIKIK-IRQLPSGNKDAKPL--LKEMKKGKEFYVIFDCSHETAAEILKQ---ILFMGMMT 250

  Fly   257 --YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHD--SRKRLEPSGQSQSQ 314
              |||..:.|   .:|    .::..:..:|:||||:::.:...|....:  |.:||:...:.::.
Mouse   251 EYYHYFFTTLDLFALD----LELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETG 311

  Fly   315 NAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESS 379
            ...|     .::.:||||||||:::..|                    ||..|..:.::
Mouse   312 LLDG-----VMTTEAALMYDAVYMVAIA--------------------SHRASQLTVSS------ 345

  Fly   380 ALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTLHVVEMSVNST---- 439
              |.|:..|    ||..|.:...::::...|||:|.|.|:: ||.|.::.|.::.:....|
Mouse   346 --LQCHRHK----PWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKAS 404

  Fly   440 ----------LQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLK 494
                      .:::..|..::||      |....:|..|.:..|...|.|.||:::|||||:..:
Mouse   405 GEVSKHLYKVWKKIGIWNSNSGL------NMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYR 463

  Fly   495 QYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKE 559
            :  ..:.|.|||||||||.||...|:..||..|:::||.||.|||:|.  .|.|:|||.|||...
Mouse   464 K--SDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQND--KGEWNGMVKELIDHR 524

  Fly   560 ADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGV 624
            ||:|::.:|||..||:|||||||||||||||:.:||....|||||||||||.:||:.|:|:.:||
Mouse   525 ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGV 589

  Fly   625 SFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLA 689
            |.||:.:.||.||||........||                      .|..|.||:|||||:.:.
Mouse   590 SCVLFVIARFTPYEWYNPHPCNPDS----------------------DVVENNFTLLNSFWFGVG 632

  Fly   690 AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNY 754
            |.||||.::.|.:::.||...:|||||:|:|||||||||||||||||.:||.:.:||..||.:.|
Mouse   633 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY 697

  Fly   755 GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS-VHTYDEGIRRVRQSKGKYALLVESPKNEYV 818
            |.:..|||..||::|:|..:.|||.:|::.|..: |...||||:||..:  .||||:||...|||
Mouse   698 GAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTT--DYALLMESTSIEYV 760

  Fly   819 NARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQ 883
            ..| .|:..::|..||:||:||.||||||.|.::..|:|.|:|.|:|..::.||| ....|. ::
Mouse   761 TQR-NCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW-RGNGCP-EE 822

  Fly   884 ETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            ::...:.|.:.|:.||:.:|..||:|:|.|||.||..:::
Mouse   823 DSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	105/447 (23%)
		ANF_receptor	53..434	CDD:279440	98/398 (25%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	195/402 (49%)
		Lig_chan	612..907	CDD:278489	124/295 (42%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	107/456 (23%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	195/398 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650