Protein Alignment GluRIA and Grid1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Alignment Length: 949
• Identity: 271/949 - (28%)
• Similarity: 434/949 - (45%)
• Gaps: 154/949 - (16%)

  Fly    33 TVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAY-VDVINTADAFKLSRLICN 96
            ||.....|.:|||||:........|:.|:.:.:||....:.|...| :.||...:.|:..:..|:
Mouse    17 TVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACD 81

  Fly    97 QFSRGVYSMLGAVSPDSFDTLHSYSNTFQMP--FV--TPWFPEKV---LAPSSGLLDFAISMRPD 154
            ..::|:.:::.:....|.:.|.|.::...:|  ||  .|....:.   |.||.....:.::.||.
Mouse    82 LMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPP 146

  Fly   155 --YHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQ-IYQELKPGNETFRVQMVKRIANVTMAIEFL 216
              .:..::..:....||..:..|||...:..||. :.|..:.|.:....::.|.|::|..::...
Mouse   147 VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTT 211

  Fly   217 HTLEDLGRF--SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHW--------- 270
            ...|:|.|:  :.:|.:|....:.|...|.:.| :..|..:           |:||
Mouse   212 MKTEELNRYRDTLRRAILLLSPQGAHSFINEAV-ETNLASK-----------DSHWVFVNEEISD 264

  Fly   271 PS--DVVEFGAINITGFRIV----DSNRRAVRDFHDSRKRL-EPSGQSQSQNAGGPNSLPAISAQ 328
            |.  |:|......:|..|.:    ..|::.:|:.|.....| :|.          ...|..:...
Mouse   265 PEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQ----------EGYLQMLQIS 319

  Fly   329 AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC--NTSKGWV 391
            ...:||:|.:|..||:|.|.           .|:.|             |.|.|:|  .::|
Mouse   320 NLYLYDSVLMLANAFHRKLE-----------DRKWH-------------SMASLNCIRKSTK--- 357

  Fly   392 TPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNST----LQQVAEWRDDAGL 452
             ||..|..:...::|..|.||:|.:.|.||.........::..:.:.|    ::::|.|..:.||
Mouse   358 -PWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL 421

  Fly   453 LPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGN-DRFEGYCKDLA 516
                  |.:...|    ..|...:..|..|.::||||::.:     .|:::|. .|::|:..|:.
Mouse   422 ------NGSLQER----PMGSRLQGLTLKVVTVLEEPFVMV-----AENILGQPKRYKGFSIDVL 471

  Fly   517 DMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSK 581
            |.||..||.||||....||.||  :|.....|:||:||||.|.||:||||:|||.|||.|:||||
Mouse   472 DALAKALGFKYEIYQAPDGRYG--HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSK 534

  Fly   582 PFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW--ISVILSYVGVSFVLYFVTRFPPYEWRIVRR 644
            .:|...:.|:|||| ::...:||...|....:|  |:..:..||   ||.||          :.|
Mouse   535 RYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVVG---VLIFV----------LNR 585

  Fly   645 PQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAA 709
            .||                ...|:...|.|....|:.::.|....||:|||.:.:..|:|.||..
Mouse   586 IQA----------------VRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVM 634

  Fly   710 AVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRR------ 768
            ..||.||:|:.|||||||||||||.||..||:|.:||:.|.:::|||:...:.:|:||.
Mouse   635 GSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPL 699

  Fly   769 SQIGLHNKMWEYM--NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN-ARPPCDTMKVG 830
            .|.....::|..:  |....:.|....||||:.:  ||.||.|.:....||.. ....|....:|
Mouse   700 EQDSTFAELWRTISKNGGADNCVSNPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIG 762

  Fly   831 RNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNE---LS 892
            .:|.:||:|:|...|||.|...::.:|.|::.|:|..::.|||.....|:|...:||..|   |.
Mouse   763 NSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQTEGKSLK 827

  Fly   893 LSNVAGIYYILIGGLLLAVIVAIMEFF-----CRNKTPQ 926
            |.:.||::.||..|||||.:||.:|.:     |..:||:
Mouse   828 LHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPK 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	94/449 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	149/413 (36%)
		Lig_chan	610..906	CDD:459656	101/309 (33%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		98/474 (21%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	95/455 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	148/408 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960