DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grid1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	949	Identity:	271/949 - (28%)
Similarity:	434/949 - (45%)	Gaps:	154/949 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAY-VDVINTADAFKLSRLICN 96
            ||.....|.:|||||:........|:.|:.:.:||....:.|...| :.||...:.|:..:..|:
Mouse    17 TVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACD 81

  Fly    97 QFSRGVYSMLGAVSPDSFDTLHSYSNTFQMP--FV--TPWFPEKV---LAPSSGLLDFAISMRPD 154
            ..::|:.:::.:....|.:.|.|.::...:|  ||  .|....:.   |.||.....:.::.||.
Mouse    82 LMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPP 146

  Fly   155 --YHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQ-IYQELKPGNETFRVQMVKRIANVTMAIEFL 216
              .:..::..:....||..:..|||...:..||. :.|..:.|.:....::.|.|::|..::...
Mouse   147 VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTT 211

  Fly   217 HTLEDLGRF--SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHW--------- 270
            ...|:|.|:  :.:|.:|....:.|...|.:.| :..|..:           |:||
Mouse   212 MKTEELNRYRDTLRRAILLLSPQGAHSFINEAV-ETNLASK-----------DSHWVFVNEEISD 264

  Fly   271 PS--DVVEFGAINITGFRIV----DSNRRAVRDFHDSRKRL-EPSGQSQSQNAGGPNSLPAISAQ 328
            |.  |:|......:|..|.:    ..|::.:|:.|.....| :|.          ...|..:...
Mouse   265 PEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQ----------EGYLQMLQIS 319

  Fly   329 AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC--NTSKGWV 391
            ...:||:|.:|..||:|.|.           .|:.|             |.|.|:|  .::|
Mouse   320 NLYLYDSVLMLANAFHRKLE-----------DRKWH-------------SMASLNCIRKSTK--- 357

  Fly   392 TPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNST----LQQVAEWRDDAGL 452
             ||..|..:...::|..|.||:|.:.|.||.........::..:.:.|    ::::|.|..:.||
Mouse   358 -PWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL 421

  Fly   453 LPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGN-DRFEGYCKDLA 516
                  |.:...|    ..|...:..|..|.::||||::.:     .|:::|. .|::|:..|:.
Mouse   422 ------NGSLQER----PMGSRLQGLTLKVVTVLEEPFVMV-----AENILGQPKRYKGFSIDVL 471

  Fly   517 DMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSK 581
            |.||..||.||||....||.||  :|.....|:||:||||.|.||:||||:|||.|||.|:||||
Mouse   472 DALAKALGFKYEIYQAPDGRYG--HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSK 534

  Fly   582 PFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW--ISVILSYVGVSFVLYFVTRFPPYEWRIVRR 644
            .:|...:.|:|||| ::...:||...|....:|  |:..:..||   ||.||          :.|
Mouse   535 RYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVVG---VLIFV----------LNR 585

  Fly   645 PQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAA 709
            .||                ...|:...|.|....|:.::.|....||:|||.:.:..|:|.||..
Mouse   586 IQA----------------VRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVM 634

  Fly   710 AVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRR------ 768
            ..||.||:|:.|||||||||||||.||..||:|.:||:.|.:::|||:...:.:|:||.
Mouse   635 GSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPL 699

  Fly   769 SQIGLHNKMWEYM--NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN-ARPPCDTMKVG 830
            .|.....::|..:  |....:.|....||||:.:  ||.||.|.:....||.. ....|....:|
Mouse   700 EQDSTFAELWRTISKNGGADNCVSNPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIG 762

  Fly   831 RNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNE---LS 892
            .:|.:||:|:|...|||.|...::.:|.|::.|:|..::.|||.....|:|...:||..|   |.
Mouse   763 NSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQTEGKSLK 827

  Fly   893 LSNVAGIYYILIGGLLLAVIVAIMEFF-----CRNKTPQ 926
            |.:.||::.||..|||||.:||.:|.:     |..:||:
Mouse   828 LHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPK 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	93/446 (21%)
		ANF_receptor	53..434	CDD:279440	84/411 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	149/413 (36%)
		Lig_chan	612..907	CDD:278489	101/308 (33%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		98/474 (21%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	94/453 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	148/408 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740