Protein Alignment GluRIA and Gria4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_006509904.1
• Gene: Gria4 / 14802
• MGIID: 95811
• Length: 912
• Species: Mus musculus
• Alignment Length: 971
• Identity: 382/971 - (39%)
• Similarity: 548/971 - (56%)
• Gaps: 106/971 - (10%)

  Fly    11 LHFICASSI-----FWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNL--NV 68
            :..||...:     ||.....|        ....:.:|.:|.:.||...:||:.|:..||.  |.
Mouse     1 MRIICRQIVLLFSGFWGLAMGA--------FPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNA 57

  Fly    69 SSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWF 133
            |...|.|..:||.|.||::|.::...|:|:||||:::.|.....|..||.|:.:...:..:||.|
Mouse    58 SEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSF 122

  Fly   134 PEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETF 198
                  |:.|...|.:.:||....|::..:.:|.|...::|||:..|...||.|.:  |.|...:
Mouse   123 ------PTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIME--KAGQNGW 179

  Fly   199 RVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLL 261
            .|..: .:.|.. .:.:...||:|.|..:|:.|:||..|..:.|:.|.|   .:|:  :.|||::
Mouse   180 HVSAI-CVENFN-DVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIV---SVGKHVKGYHYII 239

  Fly   262 SGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAIS 326
            :.|...:......:..|| |:|||::||.|...|....|..|:|:      .:...|..:.|..:
Mouse   240 ANLGFKDISLERFIHGGA-NVTGFQLVDFNTPMVTKLMDRWKKLD------QREYPGSETPPKYT 297

  Fly   327 AQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWV 391
              :||.||.|.|:.|.|..:.|:|.|      :.||.:.|                ||..:.  .
Mouse   298 --SALTYDGVLVMAETFRSLRRQKID------ISRRGNAG----------------DCLANP--A 336

  Fly   392 TPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLH 456
            .||.||..:.|.|::|.|.||:|.::||..|||:|||:.|.|:. ::..::|..|.|...|:.:.
Mouse   337 APWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELK-STGPRKVGYWNDMDKLVLIQ 400

  Fly   457 SHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAA 521
            ......:..:|.       .|.|.:|::::|.||:..|:  ..|...|||::||||.|||..:|.
Mouse   401 DAPTLGNDTAAI-------ENRTVVVTTIMESPYVMYKK--NHEMFEGNDKYEGYCVDLASEIAK 456

  Fly   522 QLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTL 586
            .:||||:|.:|.||.|||.:.... .|:||||||:..:|:|||:.:|||..||.|||||||||:|
Mouse   457 HIGIKYKIAIVPDGKYGARDADTK-IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSL 520

  Fly   587 GISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTA 651
            |||||||||.|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||.         |.
Mouse   521 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH---------TE 576

  Fly   652 QQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFT 716
            :...|..|.:          ..|||||.:.||.|:||.|||||||||:|.|::|||...||||||
Mouse   577 EPEDGKEGPS----------DQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 631

  Fly   717 IILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM 781
            :|:||||||||||||||||||:||::.|||..||::.||||..|||.||||||:|.::.|||.||
Mouse   632 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYM 696

  Fly   782 -NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIG 845
             :|.......|..||:.|||:||||:|.|:||..|||:..|.||||||||.|:|:||:|||||.|
Mouse   697 RSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKG 761

  Fly   846 SPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYILIGGLL 908
            |.||..:|.|||.|.|.|.|.:::||||:||.||......|  ..:.||||||||::|||:|||.
Mouse   762 SSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLG 826

  Fly   909 LAVIVAIMEFFCRN----------KTPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAIMH 959
            ||::||::||..::          |:.|..:|.|:.:...:.....:..::.......::|
Mouse   827 LAMLVALIEFCYKSRAEAKRMKVAKSAQTFNPTSSQNTHNLATYREADFFRSHKKQSQVIH 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	125/418 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	223/402 (55%)
		Lig_chan	610..906	CDD:459656	162/298 (54%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	125/418 (30%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	223/402 (55%)