DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Gria2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	984	Identity:	393/984 - (39%)
Similarity:	541/984 - (54%)	Gaps:	194/984 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101
            :..|.:|.:|.:|.|...|||:..|    :..|:..|.|..::|.:..|::|.::...|:|||||
Mouse    24 SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166
            ||::.|.....|.:|:.|:..|..:.|:||.|      |:.|...|.|.||||...|::..|:||
Mouse    85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTDGTHPFVIQMRPDLKGALLSLIEYY 143

  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQE----------LKPGN-------ETFRVQMVKRIANVTMAIE 214
            .|....|||||..||..||.:...          :..||       ||:|
Mouse   144 QWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYR--------------- 193

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV--V 275
              ...:||....::|::|||..:...:|:.|   .|.:|:  :.|||:::.|...:   .|:  :
Mouse   194 --SLFQDLELKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTD---GDLLKI 250

  Fly   276 EFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV 340
            :||..|::||:|||.:...|..|.:....||......:..|       .|...:||.||||.|:.
Mouse   251 QFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTA-------TIKYTSALTYDAVQVMT 308

  Fly   341 EAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLR 405
            ||| |.|||:..:     :.||.:.|                ||..:.  ..||.||.:|.|.|:
Mouse   309 EAF-RNLRKQRIE-----ISRRGNAG----------------DCLANP--AVPWGQGVEIERALK 349

  Fly   406 KVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNS---------------TLQQVAEWRDDAGLLPL 455
            :|:::||||.|:||::|:|||||::::|:..|.               ||.::....|.:||
Mouse   350 QVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGL--- 411

  Fly   456 HSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLA 520
                                .|.|.:|:::||.||:.:|:  ..|.|.||:|:||||.|||..:|
Mouse   412 --------------------ENKTVVVTTILESPYVMMKK--NHEMLEGNERYEGYCVDLAAEIA 454

  Fly   521 AQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMT 585
            ...|.||::.:|.||.|||.:.... .|:||||||:..:|||||:.:|||..||.|||||||||:
Mouse   455 KHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518

  Fly   586 LGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV-----RRP 645
            ||||||||||.|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||...     |..
Mouse   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583

  Fly   646 QADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAA 710
            |:..:.                        |||.:.||.|:||.|||||||||:|.|::|||...
Mouse   584 QSSEST------------------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 624

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHN 775
            ||||||:|:||||||||||||||||||:||::.|||:.||::.||||..|||.||||||:|.:.:
Mouse   625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFD 689

  Fly   776 KMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFG 839
            |||.|| :|.....|.|..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|
Mouse   690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 754

  Fly   840 VATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYI 902
            :|||.||.||..:|.|||.|.|.|.|.:::||||:||.||......|  ..:.||||||||::||
Mouse   755 IATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYI 819

  Fly   903 LIGGLLLAVIVAIMEFFC------------------RNKTPQLKSPGSNGSAGGV---------- 939
            |:|||.||::||::| ||                  |||. :|...||.|..|.|
Mouse   820 LVGGLGLAMLVALIE-FCYKSRAEAKRMKMTLSAATRNKA-RLSITGSTGENGRVMTPEFPKAVH 882

  Fly   940 ------PGM 942
                  |||
Mouse   883 AVPYVSPGM 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	133/447 (30%)
		ANF_receptor	53..434	CDD:279440	123/401 (31%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	222/407 (55%)
		Lig_chan	612..907	CDD:278489	161/302 (53%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	129/433 (30%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	222/407 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846192
Domainoid	1	1.000	347	1.000	Domainoid score	I1032
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I650
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm8866
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760