Protein Alignment GluRIA and Gria1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 972
• Identity: 382/972 - (39%)
• Similarity: 551/972 - (56%)
• Gaps: 133/972 - (13%)

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYS 104
            |.:|.:|........:||::|     |:..:...:|...:|::|.:|:|:::...|:|||:|||:
Mouse    25 IQIGGLFPNQQSQEHAAFRFA-----LSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYA 84

  Fly   105 MLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQ 169
            :.|.....:.:.|.|:.....:.|:||.||    ..:|.  .|.:.:||:..:|:|..|.:|.||
Mouse    85 IFGFYERRTVNMLTSFCGALHVCFITPSFP----VDTSN--QFVLQLRPELQEALISIIDHYKWQ 143

  Fly   170 SIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC 234
            :.:|:||:..||..||::.......|  ::|..|..:.........|  .:||.:..::.:|:||
Mouse   144 TFVYIYDADRGLSVLQRVLDTAAEKN--WQVTAVNILTTTEEGYRML--FQDLEKKKERLVVVDC 204

  Fly   235 PAEMAKEIIVQHVRDIKLGRRTYHYLLSGL-VMDNHWPSDVVEF---GAINITGFRIVDSN---- 291
            .:|....|:.|.|:..|.| ..|||:|:.| .||    .|:.:|   || |:|||::|:..
Mouse   205 ESERLNAILGQIVKLEKNG-IGYHYILANLGFMD----IDLNKFKESGA-NVTGFQLVNYTDTIP 263

  Fly   292 RRAVRDFH--DSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQF 354
            .|.::.:.  |:|.......:.....             :||.||.|.|:.|||..:.|::.|
Mouse   264 ARIMQQWRTSDARDHTRVDWKRPKYT-------------SALTYDGVKVMAEAFQSLRRQRID-- 313

  Fly   355 RSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFD 419
                :.||.:.|                ||..:.  ..||.||..|.|.|::|..:||:|.::|:
Mouse   314 ----ISRRGNAG----------------DCLANP--AVPWGQGIDIQRALQQVRFEGLTGNVQFN 356

  Fly   420 EDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSS 484
            |.|||.||||||:||. :..::::..|.:|...:|..:...|....|:.       :|.||||::
Mouse   357 EKGRRTNYTLHVIEMK-HDGIRKIGYWNEDDKFVPAATDAQAGGDNSSV-------QNRTYIVTT 413

  Fly   485 LLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWD 549
            :||:||:.||:  ......||||:||||.:||..:|..:|..|.:.:|.||.|||.:.... .|:
Mouse   414 ILEDPYVMLKK--NANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTK-AWN 475

  Fly   550 GMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW 614
            ||||||:...||:|::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||
Mouse   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW 540

  Fly   615 ISVILSYVGVSFVLYFVTRFPPYEWRI--VRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNE 677
            :.::.:|:|||.||:.|:||.||||..  ....:..:|:.|                     .||
Mouse   541 MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQ---------------------SNE 584

  Fly   678 FTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKT 742
            |.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::
Mouse   585 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 649

  Fly   743 PEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKY 806
            .|||..||::.||||..|||.||||||:|.:..|||.|| :|.....|.|.:||:.|||:|||||
Mouse   650 AEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY 714

  Fly   807 ALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK 871
            |.|:||..|||:..|.||||||||.|:|:||:|:|||.||.||..:|.|||.|.|.|.|.:::||
Mouse   715 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNK 779

  Fly   872 WWFDKTECNL---DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-------------FC 920
            ||:||.||..   |.:..| :.||||||||::|||||||.||::||::||             ||
Mouse   780 WWYDKGECGSGGGDSKDKT-SALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFC 843

  Fly   921 -----------RNKT-PQLKSPGSNGSAG-GVPGMLASSTYQRDSLSDAIMHSQAKLAMQAS 969
                       |..| |:....|::|.:| |..|.:.|..:.:...|...|...:.:.:.|:
Mouse   844 LIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGAT 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	120/424 (28%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	220/404 (54%)
		Lig_chan	610..906	CDD:459656	162/301 (54%)
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	120/424 (28%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	220/404 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		7/23 (30%)
		PDZ-binding	904..907		1/2 (50%)