Protein Alignment GluRIA and Nmdar1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_321646.4
• Gene: Nmdar1 / 1281696
• VectorBaseID: AGAMI1_011915
• Length: 966
• Species: Anopheles gambiae
• Alignment Length: 1012
• Identity: 236/1012 - (23%)
• Similarity: 409/1012 - (40%)
• Gaps: 217/1012 - (21%)

  Fly    42 LGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTAD--AFKLSRLICNQ-FSRGVY 103
            :|.:......:...|...|.||.:.....|.   ..|.|.....|  ..|.:..:|.. .||.||
Mosquito    38 IGGVLSNNESESHFATVIAHLNFDQQYVPRG---TTYYDKTIRIDKNPIKTALNVCKHLISRRVY 99

  Fly   104 SML------GAVSPDSFDTLHSYSNTF-QMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAII- 160
            :::      |.:||.:.    ||::.| |:|.:.....|...:..:..:.|..::.|.||||.:
Mosquito   100 AVVVSHEPTGDLSPAAV----SYTSGFYQIPVIGISSREAAFSDKNIHVSFLRTVPPYYHQADVW 160

  Fly   161 -DTIQYYGWQSIIYLYDSH-DGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLG 223
             :.:.::|:..:|.::.|. ||...|.:.....:...:...|:     |.|...:||...|:.
Mosquito   161 LEILSHFGYTKVIIIHSSDTDGRAVLGRFQTTSQTNYDDIDVR-----ATVESIVEFEPKLDS-- 218

  Fly   224 RFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSG-----LVMDNHWPSDVVEFGAINIT 283
             ||                  .::.|:|..:...:.|.:.     ::..:....::.|:|.|.|.
Mosquito   219 -FS------------------SYLMDMKTAQSRVYLLYASQEDAYVIFRDAAIHNMTEYGHIWIV 264

  Fly   284 GFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILR 348
            ..:.:.:|.             .|:|....:.....|....|.       ||:::|..|...:.
Mosquito   265 TEQALSANN-------------TPTGIIGLKLNNAENETDHIK-------DAIYILASAIKEMT- 308

  Fly   349 KKPDQFRSNHLQRRSHGGSSSSSATGTNE--SSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDG 411
                                      .||  :.|..||:.| |.:  ||.|:::...|:...|.|
Mosquito   309 --------------------------VNETITEAPKDCDDS-GVI--WESGKRLFGYLKTRNIRG 344

  Fly   412 LSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAG----LLPLHSHNYASSSRSASASTG 472
            .:|::.||::|.|:.....|:.:..|.:..:|..:..|:.    .|.::..:......:.....|
Mosquito   345 ETGQVAFDDNGDRMYAEYDVINVHENHSFVKVGSFHYDSEKRKMRLKINDSSITWPGNTGKKPEG 409

  Fly   473 DYDRNHTYIVSSLLEEPYLSLKQYTYGESLV--------------------GNDR---FEGYCKD 514
            .....|..:::  :||     |.:.|...|:                    ||::   .:|||.|
Mosquito   410 IMIPTHLKVLT--IEE-----KPFVYARKLLDDEIDCADDEVVCPHFNITNGNEQEYCCKGYCID 467

  Fly   515 LADMLAAQLGIKYEIRLVQDGNYG---AENQYAPGG------WDGMVGELIRKEADIAISAMTIT 570
            |...||.::...|::.|..||.:|   .:|.....|      |:|::|||:.:.||:.::.:||.
Mosquito   468 LLKALAQRINFTYDLALSPDGQFGHYQLKNHTTGIGTTVKKEWNGLIGELVAERADLIVAPLTIN 532

  Fly   571 AERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFP 635
            .||...|:|||||...||:|:.|||.:.:. :.|||.|.|..:||.|::|...|:.|||.:.||.
Mosquito   533 PERAEFIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFS 596

  Fly   636 PYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGC-DIT 699
            |:                     |...||....    ...:...:.::.|::....:..|. :.|
Mosquito   597 PF---------------------GRFKLSTTDG----TEEDALNLSSAIWFAWGVLLNSGIGEGT 636

  Fly   700 PPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPI---------KTPEDLTMQTDVNYG 755
            |.|.:.|:...||..|.:|:::||||||||||.:||....:         .|.|:||..|
Mosquito   637 PRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLTGINDARLRNTMENLTCAT----- 696

  Fly   756 TLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNA 820
              :.||:.:.:.|.|:.|.| |:..|.||.:   .|.::.|:.|:..| ..|.:.:|.:.|| .|
Mosquito   697 --VKGSSVDMYFRRQVELSN-MYRTMEANNY---DTAEQAIQDVKDGK-LMAFIWDSSRLEY-EA 753

  Fly   821 RPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQET 885
            ...|:.:..|......|:||....|||....:..|:|...|:|.:..:..:|.|.......:|..
Mosquito   754 SKDCELVTAGELFGRSGYGVGLQKGSPWTDAVTLAILDFHESGFMESLDKEWIFHGNVQQCEQFE 818

  Fly   886 STPNELSLSNVAGIYYI----LIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAGGVPGMLASS 946
            .|||.|.|.|:||::.:    ::||:.|.:|..:.      |..|:|.......|.........:
Mosquito   819 KTPNTLGLKNMAGVFILVGAGIVGGIGLIIIEVVY------KKHQIKKQKKMEIARHAADKWRGT 877

  Fly   947 TYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVELAS 983
            ..:|.:|       :|.||||  .:|:   ||:...|
Mosquito   878 IEKRKTL-------RASLAMQ--RQYN---VGLNSVS 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	83/437 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	124/443 (28%)
		Lig_chan	610..906	CDD:459656	84/309 (27%)
Nmdar1	XP_321646.4	None