Protein Alignment GluRIA and Ir76b

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_061511889.1
• Gene: Ir76b / 1280702
• VectorBaseID: AGAMI1_009346
• Length: 658
• Species: Anopheles gambiae
• Alignment Length: 552
• Identity: 123/552 - (22%)
• Similarity: 214/552 - (38%)
• Gaps: 120/552 - (21%)

  Fly   419 DEDGRRINYT------LHVVEMSVNSTLQQVAEWRDDAGLLPL-----HSHNYASSSRSASASTG 472
            |...||...|      |.::.|.|.:|.|...   |..|:.|:     .:..|......|||...
Mosquito    37 DPQRRRYGMTATVAVALAMMMMIVVATTQLGV---DAQGIAPVEWDGNETTEYYQLEMDASAEVK 98

  Fly   473 DYDRNH--------TYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEI 529
            :.:...        |..|::|.:.|      .:|...:.|.....|...:|.:.|..:....||:
Mosquito    99 EREMQELRRRLTGTTLRVTTLQDWP------LSYTVKINGTYIGAGVAFELLEFLMEKFNFTYEL 157

  Fly   530 RLVQDGNYGAENQYAPGGWDGMVGELIRK-EADIAISAMTITAERERVIDFSKPFMTLGISIMIK 593
            .:.:....|:.|..|     |.|.:|:.. .||:|:|.:.|.|:..:.|.:|.. :..|..|||.
Mosquito   158 VMPEQNIVGSSNDMA-----GSVLQLLTNGTADMAVSFLPILADARQHIRYSTG-LDEGEWIMIM 216

  Fly   594 -KPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGI 657
             :|::...| ...|.|.::::||.:::|.:.|..::|.:         ::.|.:.....:|   |
Mosquito   217 VRPMESASG-SGLLAPFNRDVWILILVSLLAVGPIIYGL---------LILRHRLTKDKEQ---I 268

  Fly   658 IGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISS 722
            |                   :|:.:..|:...|.|:||..::|...:.||..|.||.|..||.|.
Mosquito   269 I-------------------YTLPHCVWFVYGALMKQGSTLSPTGDSTRILFASWWIFITILTSF 314

  Fly   723 YTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQ-- 785
            |||||.||||:.:...||...||: .:.:..:.|:..|:.       :..:.|:. |.:||..
Mosquito   315 YTANLTAFLTLSKFTLPINNAEDV-RRKEKQFVTIRGGAI-------EYAIKNRD-EALNALSVL 370

  Fly   786 ------HHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTM-----KVGRNIDTKGFG 839
                  ..:.:..|......:.:|..|.         :|..||..|.|     .|.|.|:.|...
Mosquito   371 VDKRLVDFTTNVNDSDTLADKVAKQNYV---------FVRDRPAIDHMIYADYLVRRKINPKNER 426

  Fly   840 VATPIG---SPLRKRLNEA----------------VLTLKENGELLRIRNKWWFDKTECNLDQET 885
            |..|..   :|..|| |.|                :|.:.|.| :::.:......|.|.......
Mosquito   427 VHCPYATATTPFLKR-NRAFGYPPNTEWNRIFDPELLKMVEGG-IVKYKLHDRLPKAEICPQNLG 489

  Fly   886 STPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            .|..:|...::...|::::.|.:.:::|...|
Mosquito   490 GTERQLKNRDLVMTYFVMVTGFVTSIVVFASE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	12/47 (26%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	100/443 (23%)
		Lig_chan	610..906	CDD:459656	71/327 (22%)
Ir76b	XP_061511889.1	None