Protein Alignment GluRIA and LOC1276211

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_061508400.1
• Gene: LOC1276211 / 1276211
• VectorBaseID: AGAMI1_008450
• Length: 1798
• Species: Anopheles gambiae
• Alignment Length: 696
• Identity: 153/696 - (21%)
• Similarity: 259/696 - (37%)
• Gaps: 219/696 - (31%)

  Fly   358 HLQRRSHGGS--SSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEID---------- 410
            |...|..||:  ::.|..||..::|      ..|..|.|.:...|:.  |.|.:|
Mosquito   818 HHADRGEGGARYTNPSVNGTAPNTA------GTGITTKWRRVGLITG--RSVHLDTIIWPGGDVT 874

  Fly   411 --GLSGEIR--FDEDGRRINYTL---HVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSAS 468
              ||:|:.:  |     |:..::   .|:|.|||...|.:      .||:....  |.:...:.:
Mosquito   875 VSGLAGKAKTMF-----RVVVSVAPPFVMESSVNEEGQCL------RGLICYQI--YTTGRHNLT 926

  Fly   469 ASTGDYDRNH----TYIVSS--LLEEPYLSLKQY----TYGESLVGNDRFEGYCKDLADMLAAQL 523
            ....:.:|.:    ....||  |.|||......|    .||.|:           ||...||.::
Mosquito   927 LMFNEIERRNRLREIQPASSLHLQEEPRQKYPLYRTRCCYGLSM-----------DLLQKLATEI 980

  Fly   524 GIKYEIRLVQDGNYG------------------------AENQY---APGG-------------- 547
            ...:.:.:|.||.:|                        .|:|.   |..|
Mosquito   981 NFDFHLYIVHDGLFGRRVPPPPEPTEPPTNVRKPAVATHVESQSKFDAQSGRSLKRGSKLKLSQA 1045

  Fly   548 ----------------------------WDGMVGELIRKEADIAISAMTITAERERVIDFSKPFM 584
                                        |:|::|:||...||::.:.::::..|..||||:.|:.
Mosquito  1046 GINASARDEGPQYPFEVPAAPPVRTRQLWNGVIGDLISGTADLSFAPLSVSKARSEVIDFTIPYF 1110

  Fly   585 TLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADS 649
            ..|:|::..........:.:||.|.|.|:||::..| :.|:.|...:     |||
Mosquito  1111 HGGVSLLAAPEAATDIPLLAFLLPFSPELWIAIFTS-LNVTAVAVAI-----YEW---------- 1159

  Fly   650 TAQQPPGI-IGGATLSEPQAHVPPVPPNEFTMLNSFWY-------SLAAFMQQGCDITPPSIAGR 706
              ..|.|: ..|...|:           .|:|.::.|.       .|.||.      .|.|...:
Mosquito  1160 --LSPFGLNPWGRQRSK-----------NFSMSSALWVMWGLLCGHLVAFK------APKSWPNK 1205

  Fly   707 IAAAVWWFFTIILISSYTANLAAFLT----------------VERMVAPIKT-PEDLTMQTDVNY 754
            ....||..|::|.|:|||||:||.:.                .:|:.:||.| .|....|.|
Mosquito  1206 FLINVWGGFSVIFIASYTANIAALIAGLLFHNEAKYYEMSMLTQRVGSPIATAAESYVQQND--- 1267

  Fly   755 GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN 819
                                .::||:|...|..|:   ||||.|:: ::....|:.::|..:|..
Mosquito  1268 --------------------KRLWEHMKKYQLQSI---DEGIERLK-NRTIDLLMCDTPILDYYR 1308

  Fly   820 AR-PPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQ 883
            .. ..|...::|.|.....:.:....|.||:|.::..:.....:|.|..:..||:.|.....||:
Mosquito  1309 GTDQSCSLQRIGDNYIEDSYAIGMSKGFPLKKTMSALISKYSHDGYLDILTAKWYGDLPCFKLDR 1373

  Fly   884 ETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME-FFCRNKTPQLK 928
            |.:.|..|.::.|||::.:|..|::|.|::.|:| .|.:...|.|:
Mosquito  1374 EMAQPKPLGVTAVAGVFLLLGVGMVLGVLILIIEHVFYKYTLPILR 1419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	28/116 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	106/506 (21%)
		Lig_chan	610..906	CDD:459656	75/321 (23%)
LOC1276211	XP_061508400.1	None