DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GRIN3A

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	927	Identity:	195/927 - (21%)
Similarity:	354/927 - (38%)	Gaps:	242/927 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 EKVLAPSSG-----LLDFAISMRP------DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIY 188
            |.|:|..:|     ||.|:....|      .:.|::..|:...|..:::....|...::.|.
Human   149 EVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELD--- 210

  Fly   189 QELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLG 253
                      .|.:|..|..:::      ...:..|.|:..:.|    :::.|..:....|:.:.
Human   211 ----------LVSLVLHIPVISI------VRHEFPRESQNPLHL----QLSLENSLSSDADVTVS 255

  Fly   254 RRTYH--YLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFH-----DSRKRLEPSGQS 311
            ..|.:  |..|.|:....|          |||.|.::..|.   ..||     :....| ||.|.
Human   256 ILTMNNWYNFSLLLCQEDW----------NITDFLLLTQNN---SKFHLGSIINITANL-PSTQD 306

  Fly   312 -----QSQNAGGPNSLPAISAQAALMYDA-------VFVLVEAFNRI---LR------KKPDQFR 355
                 |.|.....||.|.:     :|:..       :|.:...|..:   ||      :..::.|
Human   307 LLSFLQIQLESIKNSTPTV-----VMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELR 366

  Fly   356 SNHLQRR--SHGGSSSS------------------SATGTNESSALL--DCNTSKGWVTPWEQGE 398
            :..|...  :||.::.|                  :||......||:  ..|..:...|....|:
Human   367 TEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQ 431

  Fly   399 KISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNS----TLQ----------QVAEWRD- 448
            .:||.|......||||.||....         .:..|.|:    .||          ::..|:.
Human   432 YLSRFLANTTFRGLSGSIRVKGS---------TIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGG 487

  Fly   449 ----DAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPY----------------LSL 493
                |.|:.|..:..:.:..:..|       :.|..:| :|:|.|:                |.|
Human   488 KIVMDYGIWPEQAQRHKTHFQHPS-------KLHLRVV-TLIEHPFVFTREVDDEGLCPAGQLCL 544

  Fly   494 KQYTYGESLV---------GND----RFE----GYCKDLADMLAAQLGIKYEIRLVQDGNYGAEN 541
            ...|...|.:         .||    :|:    |||.||.:.:|..:...:::.:|.||.|||
Human   545 DPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGA-- 607

  Fly   542 QYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFL 606
             :..|.|.|:||:|:|..|.:|:::.:|...|.:||||:.||.:..:.|:::......| :.:|:
Human   608 -WKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFM 670

  Fly   607 NPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVP 671
            .||...:|:.:   :|.:.....|:|.   |||:            .|.|:             .
Human   671 WPLHWTMWLGI---FVALHITAVFLTL---YEWK------------SPFGL-------------T 704

  Fly   672 PVPPNE---FTMLNSFWYSLAAFMQQGCDITPPSI-AGRIAAAVWWFFTIILISSYTANLAAFLT 732
            |...|.   |:..::.....|....:...|.||.. .||....:|..|.:..:|:|||||||.:.
Human   705 PKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMV 769

  Fly   733 VERM---VAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDE 794
            .|::   ::.|..|:.........:||:...|..::.|:|...:|    |||   :.::|....:
Human   770 GEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMH----EYM---RRYNVPATPD 827

  Fly   795 GIRRVRQSKGKY-ALLVESPKNEY-VNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVL 857
            |:..::....|. |.:::....:| |:....|..:.||:....:|:|:..|..|||...::|.:.
Human   828 GVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELIS 892

  Fly   858 TLKENGELLRIRNKWW---------FDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIV 913
            ..|.:|.:..:.:||:         |..||         ..::.:.:.:|::.:|..|..|:::.
Human   893 QYKSHGFMDMLHDKWYRVVPCGKRSFAVTE---------TLQMGIKHFSGLFVLLCIGFGLSILT 948

  Fly   914 AIMEFFC-RNKTPQLKS 929
            .|.|... |...|::|:
Human   949 TIGEHIVYRLLLPRIKN 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	75/397 (19%)
		ANF_receptor	53..434	CDD:279440	68/359 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	108/452 (24%)
		Lig_chan	612..907	CDD:278489	65/312 (21%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	75/398 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	70/370 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	105/438 (24%)
		Lig_chan	676..942	CDD:278489	65/312 (21%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		4/15 (27%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740