DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grik4

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	911	Identity:	291/911 - (31%)
Similarity:	456/911 - (50%)	Gaps:	147/911 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QAYVDVINTADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMP---- 127
            :|.|:|    |.|:|.|        .:|....:||.::|| :.||.|...:.:.....::|
Mouse    61 KAKVEV----DIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121

  Fly   128 -------FVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQ 185
                   |....|....|.||:          .|...|:...:.::...:...:....:.||.|:
Mouse   122 APEEFVRFQLQRFTTLNLHPSN----------TDISVAVAGILNFFNCTTACLICAKAECLLNLE 176

  Fly   186 QIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDI 250
            ::.::.....:|..|:|:....:.|      ..|:::.......|::...|.|:..|::: ..::
Mouse   177 KLLRQFLISKDTLSVRMLDDTRDPT------PLLKEIRDDKTATIIIHANASMSHTILLK-AAEL 234

  Fly   251 KLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQN 315
            .:....|.|:.:.|.........:|: ..:||.||.|.:.:....::|..|   |..|.|....:
Mouse   235 GMVSAYYTYIFTNLEFSLQRMDSLVD-DRVNILGFSIFNQSHAFFQEFSQS---LNQSWQENCDH 295

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSA 380
            .  |.:.||:|  :||::|||:.:|.|...:.|                     |...|...
Mouse   296 V--PFTGPALS--SALLFDAVYAVVTAVQELNR---------------------SQEIGVKP--- 332

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
             |.|.:::    .|:.|..:...||.||::||:|.|.|:..|:|.||.|.:::.:.|. .||:.:
Mouse   333 -LSCGSAQ----IWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNG-FQQIGQ 391

  Fly   446 WRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYG--ESLVGNDRF 508
            |....||        :..||..:::..|...|.|.:|:::||.|||.||    |  :.:.||||:
Mouse   392 WHVAEGL--------SMDSRLYASNISDSLFNTTLVVTTILENPYLMLK----GNHQEMEGNDRY 444

  Fly   509 EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAER 573
            ||:|.|:...||..|...|:||||.||.||...  |.|.|.|||||||.::||:|::.:||||||
Mouse   445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE--ANGTWTGMVGELIARKADLAVAGLTITAER 507

  Fly   574 ERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYE 638
            |:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:.|.|..|||
Mouse   508 EKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYE 572

  Fly   639 WRIVRRPQADSTAQQP-PGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPS 702
            |            ..| |...|...|.          .|::::.||.|:.:..|||||..|.|.:
Mouse   573 W------------YSPHPCAQGRCNLL----------VNQYSLGNSLWFPVGGFMQQGSTIAPRA 615

  Fly   703 IAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFR 767
            ::.|..:.|||.||:|:||||||||||||||:||..||::.:||..||.:.|||:..||:..||:
Mouse   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQ 680

  Fly   768 RSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGR 831
            .|:...:.:||.||.:.|.. .|.:.:|||.||..|  .||.|:||..|||...| .|:..::|.
Mouse   681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQR-NCNLTQIGG 742

  Fly   832 NIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNV 896
            .:||||:|:..|:||..|...:.|:|.|:||..|..::.||| :..:|. .:|......|.:.|:
Mouse   743 LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW-EGGKCP-KEEDHRAKGLGMENI 805

  Fly   897 AGIYYILIGGLLLAVIVAIMEFF-------------CRNKTPQLKS---------PGSNGSAGGV 939
            .||:.:||.||::|:.:|::||.             |:....:|::         |....| ||:
Mouse   806 GGIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMVTELRNIILCQDNIHPRRRRS-GGL 869

  Fly   940 P 940
            |
Mouse   870 P 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	86/396 (22%)
		ANF_receptor	53..434	CDD:279440	81/377 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	180/405 (44%)
		Lig_chan	612..907	CDD:278489	114/296 (39%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	87/407 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	180/401 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750