Protein Alignment GluRIA and grik3

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_031752773.1
• Gene: grik3 / 100498426
• XenbaseID: XB-GENE-6050069
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 960
• Identity: 312/960 - (32%)
• Similarity: 498/960 - (51%)
• Gaps: 165/960 - (17%)

  Fly    19 IFWPEFSSAQQQQQTVSLTEKIPLGAIFE-------QGTDDVQSAFKY--AMLNHN---LNVSSR 71
            |||        .|....:...|.:|.|||       |.....:.||::  :::|.|   |..::.
 Frog    23 IFW--------LQSCQGMPHVIRIGGIFEHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTL 79

  Fly    72 RFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPE 135
            .:::|.    ||..|:|:.:|..|:|.:.||.::.|.....|.:.:.|..|..::|.: ..|...
 Frog    80 TYDIQR----INLYDSFEANRKACDQLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHH 140

  Fly   136 KVLAPSSGLLDFAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQI---------- 187
                |......|.:::.|||   ..||:|.:|:..|:|...:||...||:|||::
 Frog   141 ----PLDNRDSFYVNLYPDYASLSHAILDLVQFLKWRSATVVYDDSTGLIRLQELIMAPARYNIR 201

  Fly   188 --YQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDI 250
              .::|.|.:|..|                 ..|:::.|..:.||:.||...||.:|:.|   .:
 Frog   202 LKIRQLPPESEDAR-----------------PLLKEMKRGREFRIIFDCSHTMAAQILRQ---AM 246

  Fly   251 KLGRRT--YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHD--SRKRLEPS 308
            .:|..|  |||:.:.|   .:|    .:...:..:|:|||||::.:...|....|  |.:|.:.:
 Frog   247 AMGMMTEYYHYIFTTLDLYALD----LEPYRYSGVNLTGFRILNVDNPYVSSIVDKWSMERHQAT 307

  Fly   309 GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSAT 373
            .:.:|....|     .::..|||.||||.::...:.|     ..|...|.||
 Frog   308 PKPESGLLDG-----IMTTDAALTYDAVHIVSVCYQR-----APQMTVNSLQ------------- 349

  Fly   374 GTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTLHVVEMSVN 437
                      |:..|.    |..|.:....:::.:.:||:|.|.|:: .|.|.::.|.::.:..:
 Frog   350 ----------CHRHKA----WRFGSRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKED 400

  Fly   438 STLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESL 502
            . |::|..|....||      |...::|....:..:...|.|.||:::|||||:..|:  ....|
 Frog   401 G-LEKVGTWNPSDGL------NITETARGRGPNISESLTNRTLIVTTVLEEPYVMFKR--SDTPL 456

  Fly   503 VGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAM 567
            .|.|||||:|.||...:|..||..|:||||:|..||::::  .|.|:|:|.|||..:||:|::.:
 Frog   457 FGKDRFEGFCIDLLKKIAEILGFDYDIRLVEDAKYGSQDE--KGQWNGLVKELIDHKADLAVAPL 519

  Fly   568 TITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVT 632
            |||..||:|||||||||||||||:.:|.....|.|||||||||.:||:.::|:|:|||.||:.:.
 Frog   520 TITHVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIA 584

  Fly   633 RFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCD 697
            ||.||||       .|:....|     |..:.|          |.||:|||||:::.|.||||.:
 Frog   585 RFSPYEW-------YDAHPCNP-----GTDVVE----------NNFTLLNSFWFAVGALMQQGSE 627

  Fly   698 ITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGST 762
            :.|.:::.||...:|||||:|:|||||||||||||||||.:.|.:.:||..||.:.||.::.|:|
 Frog   628 LMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESAIDSADDLAKQTKIEYGAVVDGAT 692

  Fly   763 WEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTM 827
            ..||::|.|....|||.:|::.....|.:.:|||:||..:  .||||:||...||:..| .|:..
 Frog   693 MNFFKKSHISTFEKMWAFMSSRPSALVKSNEEGIQRVLSA--DYALLMESTAIEYITQR-NCNLT 754

  Fly   828 KVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELS 892
            ::|..||:||:|:.||:|||.|.|::.|:|.|:|..|:.:::.:||  ::....:::....:.|.
 Frog   755 QIGGLIDSKGYGIGTPMGSPYRDRISIAILQLQEADEIHKMKERWW--RSGGCPEEKNKEASALG 817

  Fly   893 LSNVAGIYYILIGGLLLAVIVAIMEF--------------FCRNKTPQLK 928
            :.|:.||:.:|.|||:|:|:||:.||              ||.....:::
 Frog   818 IQNMGGIFIVLAGGLILSVVVAMAEFVYKLRKTAEREQRSFCSTMADEIR 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	106/450 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	183/401 (46%)
		Lig_chan	610..906	CDD:459656	117/295 (40%)
grik3	XP_031752773.1	PBP1_iGluR_Kainate	37..417	CDD:380605	107/455 (24%)
		Periplasmic_Binding_Protein_Type_2	433..801	CDD:473866	183/398 (46%)