Protein Alignment GluRIA and grik2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_017949808.1
• Gene: grik2 / 100495093
• XenbaseID: XB-GENE-5902331
• Length: 913
• Species: Xenopus tropicalis
• Alignment Length: 913
• Identity: 318/913 - (34%)
• Similarity: 499/913 - (54%)
• Gaps: 116/913 - (12%)

  Fly    33 TVSLTEKIPLGAIFEQ------GTDDVQSAFKYAM--LNHN---LNVSSRRFELQAYVDVINTAD 86
            |...|..:..|.|||.      |.:::  ||::|:  :|.|   |..::..::.|.    ||..|
 Frog    34 TQGTTHVLRFGGIFEYVESGPFGAEEL--AFRFAVNTINRNRTLLPNTTLTYDTQR----INLYD 92

  Fly    87 AFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISM 151
            :|:.||..|.|.|.||.::.|.....|.:.:.|..|...:|.:...:..:|   |.....|.:|:
 Frog    93 SFEASRKACEQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV---SDNKDSFYVSL 154

  Fly   152 RPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAI 213
            .||:   .:||:|.:|::.|:::...||...||:|||::.:  .|.....|:: ::::...|...
 Frog   155 YPDFSSLSRAILDLVQFFKWKTVTIAYDDSTGLIRLQELIK--APSRYNLRLK-IRQLPIDTKDA 216

  Fly   214 EFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLSGLVMDNHWPSDV-- 274
            :.|  |:::.|..:..::.||..:||..|:.|   .:.:|..|  |||:.:.|.:   :..||
 Frog   217 KPL--LKEMKRGKEFHVIFDCSHDMAAGILKQ---ALAMGMMTEYYHYIFTTLDL---FALDVEP 273

  Fly   275 VEFGAINITGFRIVDSNRRAVRDFHD--SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVF 337
            ..:..:|:|||||::.....|....:  |.:||:...:..|....|     .::..||||||||.
 Frog   274 YRYSGVNMTGFRILNIENSQVLSIIEKWSMERLQAPPKPDSGLLDG-----FMTTDAALMYDAVH 333

  Fly   338 VLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISR 402
            |:..|    :::.|....|:                        |.||..|    ||..|.:...
 Frog   334 VVSVA----VQQFPQMTVSS------------------------LQCNRHK----PWRFGARFIS 366

  Fly   403 VLRKVEIDGLSGEIRFDE-DGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRS 466
            ::::...:||:|.|.|:: :|.|.::.|.|:.:. ...|:::..|...:||      |...:.:.
 Frog   367 LIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLK-EEGLEKIGTWDPTSGL------NMTENQKG 424

  Fly   467 ASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRL 531
            ..|:..|...|.:.||:::|||||:..|:  ..:.|.|..||||||.||.:.|:..||.:||:||
 Frog   425 KPANITDSLSNRSLIVTTILEEPYVMFKK--SDKPLYGKARFEGYCIDLLEKLSKILGFEYEVRL 487

  Fly   532 VQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPV 596
            |:||.|||::. ....|:|||.||:..:||:|::.:.||..||:||||:||||||||||:.:||.
 Frog   488 VEDGKYGAKDD-TTQQWNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMTLGISILYRKPN 551

  Fly   597 KQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGA 661
            ...|||||||||||.:||:.::|:|:|||.||:.:.||.||||........||
 Frog   552 GTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS------------ 604

  Fly   662 TLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTAN 726
                      .|..|.||:|||||:.:.|.||||.::.|.:::.||...:|||||:|:|||||||
 Frog   605 ----------DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTAN 659

  Fly   727 LAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNA-NQHHSVH 790
            ||||||||||.:||.:.:||..||.:.||.:..|:|..||::|:|..:.|||.:||: :|...|.
 Frog   660 LAAFLTVERMESPIDSADDLAKQTKIEYGAVQDGATMTFFKKSRIPTYEKMWAFMNSRSQSVLVK 724

  Fly   791 TYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEA 855
            ..:|||:||..|  .||.|:||...|:|..| .|:..::|..||:||:||.||:|||.|.::..|
 Frog   725 NNEEGIQRVLTS--DYAFLMESTTIEFVTQR-NCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIA 786

  Fly   856 VLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFC 920
            :|.|:|.|.|..::.||| ....|. ::|:...:.|.:.|:.||:.:|..||:|:|.||:.||..
 Frog   787 ILQLQEEGVLHMMKEKWW-RGNGCP-EEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 849

  Fly   921 RNK 923
            ::|
 Frog   850 KSK 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	110/435 (25%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	187/402 (47%)
		Lig_chan	610..906	CDD:459656	123/296 (42%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	111/440 (25%)
		Periplasmic_Binding_Protein_Type_2	435..805	CDD:473866	187/398 (47%)