Protein Alignment GluRIA and grik1

DIOPT Version :9

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_004912220.1
• Gene: grik1 / 100493949
• XenbaseID: XB-GENE-957124
• Length: 928
• Species: Xenopus tropicalis
• Alignment Length: 971
• Identity: 332/971 - (34%)
• Similarity: 510/971 - (52%)
• Gaps: 167/971 - (17%)

  Fly     1 MHSRLKFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDD----VQSAFKYAM 61
            |.|..:.|  |.|:||.:...|:   |.||        .:.:|.|||...::    .:.|||:|:
 Frog    19 MESAARLL--LPFLCALAAITPQ---ASQQ--------VLRIGGIFETVENEPINVEELAFKFAV 70

  Fly    62 LNHNLN-----VSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYS 121
            .|.|.|     .::..:::|.    ||..|:|:.||..|:|.:.||.::.|.....|...:.|..
 Frog    71 TNINRNRTLMPNTTLTYDIQR----INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSIC 131

  Fly   122 NTFQMPFV-TPWFPEKVLAPSSGLLDFAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLL 182
            |..::|.: |.|....|....|    |.|::.|||   .:|:::.:.:|.|:::..:|:...||:
 Frog   132 NALEVPHIQTRWKHPSVDNKDS----FFINLHPDYAAISRAVLELVLHYSWKTVTVVYEDSTGLI 192

  Fly   183 RLQQI------------YQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCP 235
            |||::            .::|..||:..|.                 .|:::.:..:..::.||.
 Frog   193 RLQELIKAPSRYNIKIKIRQLPSGNKDART-----------------LLKEMKKSREFYVIFDCS 240

  Fly   236 AEMAKEIIVQHVRDIKLGRRT--YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAV 295
            .|.|.||:.|   .:.:|..|  |||..:.:   .:|    .:...:..:|:||||:::.:...|
 Frog   241 HETAAEILKQ---ILSMGMMTEYYHYFFTTMDLFALD----LEPYRYSGVNMTGFRLLNIDNPQV 298

  Fly   296 RDFHD--SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNH 358
            ....:  |.:||:...:.::....|     .::..||||||||:::..|..|
 Frog   299 SSVVEKWSMERLQAPPKPETGLLDG-----MMTTDAALMYDAVYMVAVATQR------------- 345

  Fly   359 LQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DG 422
                         ||....||  |.|:..|    ||..|.:...::::...|||:|.|.|:. ||
 Frog   346 -------------ATQMTVSS--LQCHRHK----PWRFGPRFMSLIKEARWDGLTGRITFNRTDG 391

  Fly   423 RRINYTLHVVEMS--------------VNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGD 473
            .|.::.:.::.:.              :|...::|..|..:.||      |...:.:..|.:..|
 Frog   392 LRRDFDMDIISLKEDGMEKAAGETVNHLNKVWKKVGVWNSNTGL------NMTDNLKDKSTNITD 450

  Fly   474 YDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYG 538
            ...|.|.||:::||:||:..::  ..:.|.|||||||||.||...|:..||..||:|||.||.||
 Frog   451 SLANRTLIVTTILEDPYVMFRK--SDKPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYG 513

  Fly   539 AENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVF 603
            |:|.  .|.|:|||.|||..:||:|::.:|||..||:|||||||||||||||:.:||....||||
 Frog   514 AQND--KGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 576

  Fly   604 SFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQA 668
            |||||||.:||:.|:|:.:|||.||:.:.||.||||........||
 Frog   577 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS------------------- 622

  Fly   669 HVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTV 733
               .|..|.||:|||||:.:.|.||||.::.|.:::.||...:|||||:|:||||||||||||||
 Frog   623 ---DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTV 684

  Fly   734 ERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS-VHTYDEGIR 797
            |||.:||.:.:||..||.:.||.:..|||..||::|:|..:.|||.:|::.|..: |...||||:
 Frog   685 ERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQ 749

  Fly   798 RVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKEN 862
            ||..:  .||||:||...|||..| .|:..::|..||:||:||.||||||.|.::..|:|.|:|.
 Frog   750 RVLTT--DYALLMESTSIEYVTQR-NCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEE 811

  Fly   863 GELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            |:|..::.||| ....|. ::::...:.|.:.|:.||:.:|..||:|:|.|||.||..:::
 Frog   812 GKLHMMKEKWW-RGNGCP-EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	106/458 (23%)
		ANF_receptor	53..434	CDD:279440	98/409 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	196/402 (49%)
		Lig_chan	612..907	CDD:278489	124/295 (42%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	109/477 (23%)
		ANF_receptor	61..404	CDD:279440	98/411 (24%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	196/398 (49%)
		Lig_chan	585..854	CDD:278489	124/295 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000