DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grik4

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	896	Identity:	286/896 - (31%)
Similarity:	453/896 - (50%)	Gaps:	135/896 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRFELQAYVDVINTA--DAFKLSRLICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPW 132
            |:.:.:..||:....  ..::.:..:|....:||..:|| :.||.|...:.:.....::|.:
Frog    57 RQGKARLEVDIFELLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHI--- 118

  Fly   133 FPEKVLAPSSGLLDF------AISMRP---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIY 188
               ||  .:...|.|      .:::.|   |...|:...::::...:...:....:.||.|:::.
Frog   119 ---KV--STEEFLRFQYQRFTTLNLHPSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLL 178

  Fly   189 QELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLG 253
            ::.....:...|:|:....:.|      ..|:::.......|::...|.|:..|:   ::..:||
Frog   179 RQFLISKDCLSVRMLDDTWDPT------PLLKEIRDDKTSTIIVHANASMSHTIL---MKAAELG 234

  Fly   254 RRT--YHYLLSGL--VMDN-HWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQS 313
            ..|  |.|:.:.|  |:.. ..|.|    ..:||.||.:.:.:....::|..:.:      ||..
Frog   235 MVTAYYTYIFTNLEFVLQRFESPLD----DRVNILGFSMFNQSHSYFKEFAHTLQ------QSWE 289

  Fly   314 QNAG-GPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNE 377
            :|.. .|.:.||:|  |||::|||:.:|.|...:.|                     |...|...
Frog   290 ENCDHSPFTGPALS--AALLFDAVYGIVSAVQELNR---------------------SQEIGVKP 331

  Fly   378 SSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQ 442
                |.|.:|:    .|:.|..:...||.||::||:|.:.|:..|:|.||.:.:::.: .:..|:
Frog   332 ----LSCGSSQ----IWQHGTSLMNYLRMVELEGLTGHVEFNSKGQRSNYDMKIMQYT-KTGFQE 387

  Fly   443 VAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL----EEPYLSLKQYTYGESLV 503
            :.:|....||        ....|..|.:..|...|.|.||:::|    |.|||.||  ...:.|.
Frog   388 IGQWHVTNGL--------NMDKRYFSPNASDTLVNKTLIVTTILFFLQENPYLMLK--ANHQELE 442

  Fly   504 GNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMT 568
            ||||:||:|.|:...|||.|...|:||||.||.||...  ..|.|.|||||||.::||:|::.:|
Frog   443 GNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYGVPE--LNGTWTGMVGELISRKADLAVAGLT 505

  Fly   569 ITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTR 633
            ||||||:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:.|.|
Frog   506 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR 570

  Fly   634 FPPYEWRIVRRPQADSTAQQP-PGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCD 697
            ..||||            ..| |...|...|.          .|::::.||.|:.:..|||||..
Frog   571 LTPYEW------------YSPHPCAQGRCNLL----------VNQYSLGNSLWFPVGGFMQQGST 613

  Fly   698 ITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGST 762
            |.|.:::.|..:.|||.||:|:||||||||||||||:||..||::.:||..||.:.|||:..||:
Frog   614 IAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSS 678

  Fly   763 WEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDT 826
            ..||:.|:...:.:||.||::.|.. .|.:.:|||.||..|  .||.|:||..|||...| .|:.
Frog   679 MTFFQNSRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQR-NCNL 740

  Fly   827 MKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNEL 891
            .:||..:||||:|:..|:||..|...:.|:|.|:||..|..::.||| |..:|. .:|......|
Frog   741 TQVGGLLDTKGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRKWW-DGGKCP-KEEDHRAKGL 803

  Fly   892 SLSNVAGIYYILIGGLLLAVIVAIMEFF-------------CRNKTPQLKS 929
            .:.|:.||:.:||.||::|:::|::||.             |:....:|.|
Frog   804 GMENIGGIFVVLICGLIVAILIAMLEFLWTVRNAEDSEVSVCQEMASELSS 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	82/399 (21%)
		ANF_receptor	53..434	CDD:279440	79/380 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	183/407 (45%)
		Lig_chan	612..907	CDD:278489	116/296 (39%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	83/409 (20%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	182/403 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020