Protein Alignment GluRIA and grik4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_031761990.1
• Gene: grik4 / 100490768
• XenbaseID: XB-GENE-1011875
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 896
• Identity: 286/896 - (31%)
• Similarity: 453/896 - (50%)
• Gaps: 135/896 - (15%)

  Fly    71 RRFELQAYVDVINTA--DAFKLSRLICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPW 132
            |:.:.:..||:....  ..::.:..:|....:||..:|| :.||.|...:.:.....::|.:
 Frog    57 RQGKARLEVDIFELLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHI--- 118

  Fly   133 FPEKVLAPSSGLLDF------AISMRP---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIY 188
               ||  .:...|.|      .:::.|   |...|:...::::...:...:....:.||.|:::.
 Frog   119 ---KV--STEEFLRFQYQRFTTLNLHPSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLL 178

  Fly   189 QELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLG 253
            ::.....:...|:|:....:.|      ..|:::.......|::...|.|:..|:   ::..:||
 Frog   179 RQFLISKDCLSVRMLDDTWDPT------PLLKEIRDDKTSTIIVHANASMSHTIL---MKAAELG 234

  Fly   254 RRT--YHYLLSGL--VMDN-HWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQS 313
            ..|  |.|:.:.|  |:.. ..|.|    ..:||.||.:.:.:....::|..:.:      ||..
 Frog   235 MVTAYYTYIFTNLEFVLQRFESPLD----DRVNILGFSMFNQSHSYFKEFAHTLQ------QSWE 289

  Fly   314 QNAG-GPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNE 377
            :|.. .|.:.||:|  |||::|||:.:|.|...:.|                     |...|...
 Frog   290 ENCDHSPFTGPALS--AALLFDAVYGIVSAVQELNR---------------------SQEIGVKP 331

  Fly   378 SSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQ 442
                |.|.:|:    .|:.|..:...||.||::||:|.:.|:..|:|.||.:.:::.: .:..|:
 Frog   332 ----LSCGSSQ----IWQHGTSLMNYLRMVELEGLTGHVEFNSKGQRSNYDMKIMQYT-KTGFQE 387

  Fly   443 VAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL----EEPYLSLKQYTYGESLV 503
            :.:|....||        ....|..|.:..|...|.|.||:::|    |.|||.||  ...:.|.
 Frog   388 IGQWHVTNGL--------NMDKRYFSPNASDTLVNKTLIVTTILFFLQENPYLMLK--ANHQELE 442

  Fly   504 GNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMT 568
            ||||:||:|.|:...|||.|...|:||||.||.||...  ..|.|.|||||||.::||:|::.:|
 Frog   443 GNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYGVPE--LNGTWTGMVGELISRKADLAVAGLT 505

  Fly   569 ITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTR 633
            ||||||:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:.|.|
 Frog   506 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR 570

  Fly   634 FPPYEWRIVRRPQADSTAQQP-PGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCD 697
            ..||||            ..| |...|...|.          .|::::.||.|:.:..|||||..
 Frog   571 LTPYEW------------YSPHPCAQGRCNLL----------VNQYSLGNSLWFPVGGFMQQGST 613

  Fly   698 ITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGST 762
            |.|.:::.|..:.|||.||:|:||||||||||||||:||..||::.:||..||.:.|||:..||:
 Frog   614 IAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSS 678

  Fly   763 WEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDT 826
            ..||:.|:...:.:||.||::.|.. .|.:.:|||.||..|  .||.|:||..|||...| .|:.
 Frog   679 MTFFQNSRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQR-NCNL 740

  Fly   827 MKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNEL 891
            .:||..:||||:|:..|:||..|...:.|:|.|:||..|..::.||| |..:|. .:|......|
 Frog   741 TQVGGLLDTKGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRKWW-DGGKCP-KEEDHRAKGL 803

  Fly   892 SLSNVAGIYYILIGGLLLAVIVAIMEFF-------------CRNKTPQLKS 929
            .:.|:.||:.:||.||::|:::|::||.             |:....:|.|
 Frog   804 GMENIGGIFVVLICGLIVAILIAMLEFLWTVRNAEDSEVSVCQEMASELSS 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	83/402 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	183/407 (45%)
		Lig_chan	610..906	CDD:459656	117/297 (39%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:471960	83/409 (20%)
		PBP2_iGluR_kainate_KA1	414..788	CDD:270442	182/403 (45%)