Protein Alignment GluRIA and grin2b

DIOPT Version :9

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1000
• Identity: 213/1000 - (21%)
• Similarity: 379/1000 - (37%)
• Gaps: 264/1000 - (26%)

  Fly    34 VSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF 98
            |..|:::.:..:.|:  ||.          |:|.|:.|     ..:..:|.:|...:...||:..
 Frog    37 VGTTDEVAIKDVHEK--DDF----------HHLPVTPR-----VALVTMNESDPKSIITRICDLM 84

  Fly    99 SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQA----- 158
            |.  ..:.|.|..|..|       ...:..:..:...:.|.|..|:...:..:..|..:|
 Frog    85 SD--KKVQGVVFGDDTD-------QEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQ 140

  Fly   159 -----------IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMA 212
                       :::.::.|.|    |::          .|.....||.:.|..::...|.|..:.
 Frog   141 FGPSIEQQASVMLNIMEEYDW----YIF----------SIVTTYFPGYQDFENKVRSTIENSFVG 191

  Fly   213 IEF---LH---TLED--------LGRFSKKRIVLDCPAEMAKEII-VQHVRDIKLGRRTYHYLLS 262
            .|.   :|   :|:|        |.:.....|:|.|..|.|..|. |.|    .:|...|.|.
 Frog   192 WELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAH----SVGLTGYGYT-- 250

  Fly   263 GLVMDNHW--PSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAI 325
                   |  ||.|                                 :|.:.:..|..|..|.::
 Frog   251 -------WIVPSLV---------------------------------AGDTDTVPAEFPTGLISV 275

  Fly   326 SAQ------AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC 384
            |..      .|.:.|.:.::..|.:.:|        |.|    :....|.||.....||...
 Frog   276 SYDEWDYDLPARVRDGIAIITTAASTML--------SEH----NSIPQSKSSCYNIQESRVY--- 325

  Fly   385 NTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDD 449
                       :...:.|.|..|..:|.:  :.|.|||.:::..|.::.::.....::|.:::|.
 Frog   326 -----------EAHMLKRYLINVTFEGRN--LSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDR 377

  Fly   450 AGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVG---------- 504
            :    |....|.........::.::...|..|| :|.|.|::.::..   :.|.|
 Frog   378 S----LKMKYYVWPVFELYPNSEEHKDEHLSIV-TLEEAPFVIVEDV---DPLSGTCMRNTVPCR 434

  Fly   505 -----NDRFE-----------GYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
                 .:|.|           |:|.|:...:|..:...|::.||.:|.:|.:   ..|.|:||:|
 Frog   435 KQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKK---INGTWNGMIG 496

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618
            |::.|.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|....:||.|.|.::|:.:.
 Frog   497 EVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVWVMMF 560

  Fly   619 LSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLN 682
            :..:.||.|..||.. |.|..:   .|..||  .::|.|                  |: ||:..
 Frog   561 VMLLIVSAVAVFVFEYFSPVGY---NRCLAD--GREPGG------------------PS-FTIGK 601

  Fly   683 SFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            :.|............: .|.....:|..:||.||.:|.::|||||||||:..|..|..:....|.
 Frog   602 AIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDK 666

  Fly   747 TMQTD------VNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH------SVHT-------Y 792
            ..|..      ..:||:..|||....|.:.:.:|:.|.::   ||..      |:.|       |
 Frog   667 KFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKF---NQRSVQDALLSLKTGKLDAFIY 728

  Fly   793 DEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVL 857
            |..:......:.:...||               |:..|:...|.|:|:|....|..:::::.|:|
 Frog   729 DAAVLNYMAGRDEGCKLV---------------TIGSGKVFATTGYGIAIQKDSGWKRQVDLAIL 778

  Fly   858 TLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME--FFC 920
            .|..:||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|..|||  ||.
 Frog   779 QLFGDGEMEELEALWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFFW 841

  Fly   921 RNKTPQLKSPGSNGSAGGVPGMLAS 945
            :.:...:      |...|.||::.|
 Frog   842 QLRHCFM------GVCSGKPGVVFS 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	77/450 (17%)
		ANF_receptor	53..434	CDD:279440	72/419 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	113/448 (25%)
		Lig_chan	612..907	CDD:278489	73/315 (23%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	80/463 (17%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	114/451 (25%)
		NMDAR2_C	837..1449	CDD:402274	6/29 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910