Protein Alignment GluRIA and grin2b

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 996
• Identity: 215/996 - (21%)
• Similarity: 383/996 - (38%)
• Gaps: 256/996 - (25%)

  Fly    34 VSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF 98
            |..|:::.:..:.|:  ||.          |:|.|:.|     ..:..:|.:|...:...||:..
 Frog    37 VGTTDEVAIKDVHEK--DDF----------HHLPVTPR-----VALVTMNESDPKSIITRICDLM 84

  Fly    99 SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQA----- 158
            |.  ..:.|.|..|..|       ...:..:..:...:.|.|..|:...:..:..|..:|
 Frog    85 SD--KKVQGVVFGDDTD-------QEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQ 140

  Fly   159 -----------IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMA 212
                       :::.::.|.|    |::          .|.....||.:.|..::...|.|..:.
 Frog   141 FGPSIEQQASVMLNIMEEYDW----YIF----------SIVTTYFPGYQDFENKVRSTIENSFVG 191

  Fly   213 IEF---LH---TLED--------LGRFSKKRIVLDCPAEMAKEII-VQHVRDIKLGRRTYHYLLS 262
            .|.   :|   :|:|        |.:.....|:|.|..|.|..|. |.|    .:|...|.|.
 Frog   192 WELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAH----SVGLTGYGYT-- 250

  Fly   263 GLVMDNHW--PSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAI 325
                   |  ||.|                                 :|.:.:..|..|..|.::
 Frog   251 -------WIVPSLV---------------------------------AGDTDTVPAEFPTGLISV 275

  Fly   326 SAQ------AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC 384
            |..      .|.:.|.:.::..|.:.:|        |.|    :....|.||.....||...
 Frog   276 SYDEWDYDLPARVRDGIAIITTAASTML--------SEH----NSIPQSKSSCYNIQESRVY--- 325

  Fly   385 NTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDD 449
                       :...:.|.|..|..:|.:  :.|.|||.:::..|.::.::.....::|.:::|.
 Frog   326 -----------EAHMLKRYLINVTFEGRN--LSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDR 377

  Fly   450 AGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVG---------- 504
            :    |....|.........::.::...|..|| :|.|.|::.::..   :.|.|
 Frog   378 S----LKMKYYVWPVFELYPNSEEHKDEHLSIV-TLEEAPFVIVEDV---DPLSGTCMRNTVPCR 434

  Fly   505 -----NDRFE-----------GYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
                 .:|.|           |:|.|:...:|..:...|::.||.:|.:|.:   ..|.|:||:|
 Frog   435 KQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKK---INGTWNGMIG 496

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618
            |::.|.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|....:||.|.|.::|:.:.
 Frog   497 EVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVWVMMF 560

  Fly   619 LSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLN 682
            :..:.||.|..||.. |.|..:   .|..||  .::|.|                  |: ||:..
 Frog   561 VMLLIVSAVAVFVFEYFSPVGY---NRCLAD--GREPGG------------------PS-FTIGK 601

  Fly   683 SFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            :.|............: .|.....:|..:||.||.:|.::|||||||||:..|..|..:....|.
 Frog   602 AIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDK 666

  Fly   747 TMQTD------VNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQS--- 802
            ..|..      ..:||:..|||....|.:.:.:|:.|.::   ||           |.|:.:
 Frog   667 KFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKF---NQ-----------RSVQDALLS 717

  Fly   803 --KGKY-ALLVESPKNEYVNARPP-CD--TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKE 861
              .||. |.:.::....|:..|.. |.  |:..|:...|.|:|:|....|..:::::.|:|.|..
 Frog   718 LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFG 782

  Fly   862 NGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME--FFCRNKT 924
            :||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|..|||  ||.:.:.
 Frog   783 DGEMEELEALWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFFWQLRH 845

  Fly   925 PQLKSPGSNGSAGGVPGMLAS 945
            ..:      |...|.||::.|
 Frog   846 CFM------GVCSGKPGVVFS 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	77/453 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	115/444 (26%)
		Lig_chan	610..906	CDD:459656	76/312 (24%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	80/463 (17%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	116/447 (26%)
		NMDAR2_C	837..1449	CDD:463148	7/30 (23%)