Protein Alignment GluRIA and grin2a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 985
• Identity: 213/985 - (21%)
• Similarity: 369/985 - (37%)
• Gaps: 265/985 - (26%)

  Fly    52 DVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFS---------------RG 101
            |::|.:...|        |..|::.....::|..|...:...:|:..|               ..
 Frog    44 DIRSLWTRDM--------SLDFDVNVVTLLVNQTDPKSIITHVCDLMSGTKIHGVVFGDDTDQEA 100

  Fly   102 VYSMLGAVSPDSFDT---LHSYSNTFQMPFVTPWFPEKVLAPS---SGLLDFAISMRPDYHQAII 160
            :..:|..||..:|..   :|..|:             .::|..   |....|..|::   .|||:
 Frog   101 IAQILDFVSSQTFIPILGIHGGSS-------------MIMADKDEMSTFFQFGASIK---QQAIV 149

  Fly   161 --DTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVK----------RIANV-TMA 212
              :.::.|.|              .:..|.....||...| :..:|          .:.|| |:.
 Frog   150 MLNIMEEYDW--------------HVFSIITSTFPGYRDF-ISFIKTTVDNSFVGWEVQNVITLD 199

  Fly   213 IEF--LHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVV 275
            ..:  ..||..|.:.....|:|.|..:.|..|.|: .|.:.|....:.:::..||..|   :|::
 Frog   200 TSYTDARTLTQLKKIHSSVILLYCSKDEANYIFVE-ARSLGLMGYGFVWIVPSLVTGN---TDII 260

  Fly   276 EF----GAINITGFRIVDSNRRA-VRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDA 335
            .:    |.:::: :...|.|..| |||                       .|..|:..|:.|.:.
 Frog   261 PYEFPSGLVSVS-YDDWDYNIEARVRD-----------------------GLGIITTAASAMLEK 301

  Fly   336 VFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKI 400
            ..|:.||       |...:..|                                     |:.|..
 Frog   302 HSVIPEA-------KTSCYAQN-------------------------------------ERNEPP 322

  Fly   401 SRVLRKVEI----DGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYA 461
            ...|.|..|    ||  .::.|.|||.:.|..|.|:.::::...::|.:|.:.:     .:..|.
 Frog   323 LHTLHKFMINVTWDG--KDLSFTEDGYQANPKLVVLLLNMDREWEKVGKWENKS-----LNMKYP 380

  Fly   462 SSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVG----------------NDRFE- 509
            ...|..::...|.|.||..|| :|.|.|::.::...|   |.|                |...|
 Frog   381 VWPRITASLDSDPDDNHLSIV-TLEEAPFVIVENVDY---LTGTCVRNTVPCRKYFRLNNSTTEG 441

  Fly   510 --------GYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISA 566
                    |:|.|:...|:..:...|::.||.:|.:|.:.:..   |:||:||::.|.|.:|:.:
 Frog   442 TSVKKCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHGKKIKNV---WNGMIGEVVYKRAVMAVGS 503

  Fly   567 MTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFV 631
            :||..||...:|||.||:..|||:|:.:. ..|....:||.|.|..:|:.:.:..:.||.|..||
 Frog   504 LTINEERSEAVDFSVPFVETGISVMVSRS-NGTVSPSAFLEPFSASVWVMMFVMLLLVSAVAVFV 567

  Fly   632 TR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQG 695
            .. |.|..:   .|..||..|...|                     .||:..:.|..........
 Frog   568 FEYFSPVGY---NRNLADGKAPHGP---------------------SFTIGKAVWLLWGLVFNNS 608

  Fly   696 CDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNY----- 754
            ..: .|.....:|..::|.||.:|.::|||||||||:..|..|..:....|...|...:|
 Frog   609 VPVQNPKGTTSKIIVSIWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFR 673

  Fly   755 -GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIR--RVRQSKGKY-ALLVESPKN 815
             ||:..|||....|.:...:|    :||       |..:.:|::  .|....||. |.:.::...
 Frog   674 FGTVPNGSTERNIRNNYPDMH----QYM-------VKFHQKGVQDALVSLKTGKLDAFIYDAAVL 727

  Fly   816 EYVNARPP-CDTMKVGRN--IDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKT 877
            .|:..|.. |..:.:|..  ..|.|:|:|...||..::.::.|:|....:||:..:...|.  ..
 Frog   728 NYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWL--TG 790

  Fly   878 ECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-------FCRNKTPQLKSPGSNGS 935
            .|:.::.....::|.:.|:||::|:|...:.|::|..:.|.       :|           ..|.
 Frog   791 ICHTEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFVWEHLFYWKLRYC-----------FTGV 844

  Fly   936 AGGVPGMLAS 945
            ..|.||:|.|
 Frog   845 CTGTPGLLFS 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	79/448 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	113/440 (26%)
		Lig_chan	610..906	CDD:459656	74/309 (24%)
grin2a	XP_031749422.1	PBP1_iGluR_NMDA_NR2	26..379	CDD:380601	79/452 (17%)
		PBP2_iGluR_NMDA_Nr2	395..793	CDD:270436	113/442 (26%)
		NMDAR2_C	831..1450	CDD:463148	7/35 (20%)