DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grin2cb

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	958	Identity:	207/958 - (21%)
Similarity:	352/958 - (36%)	Gaps:	237/958 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GTDDVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTADAFKLSRLICNQFSRGVYS 104
            |...|..|..::...|:..:..|         ..|:.....::|..:...|...:|.  :....|
Zfish    35 GPPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPITVLVNDTNPRALLTRLCQ--TMAAES 97

  Fly   105 MLGAVSPDSFDT------LHSYSNTFQMPFV------TPWFPEKVLAPSSGLLDFAISMRPDYHQ 157
            :.|.|..|..|:      |...|:...:|.|      ....|.|  |..|..|....|:....:
Zfish    98 LHGVVFEDDVDSEAVAQILDFVSSQTSIPIVGISGGSAVVIPHK--ADGSTFLQMGASIDQQIN- 159

  Fly   158 AIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDL 222
            |:...::.|.|.:.:              :...|.||.|||    |..|.:.|....||..|:|:
Zfish   160 AMFKVMEEYNWGNFV--------------VITSLYPGYETF----VDYIRSFTDTSYFLWELQDV 206

  Fly   223 GRFS--------KKRIVLD----------CPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNH 269
            ..|.        :.|.:|.          |..|.| :.:.:...|:.|....|.:::..|.:.|.
Zfish   207 LSFEMSVGANDIRTRRLLQQVDSQVYLVYCSHEEA-QYLFRMASDVGLLGPGYIWIVPSLAVGNP 270

  Fly   270 WPSDVVEF--GAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALM 332
            ..:....|  |.|:|    |.|..|:.:|    .|.|
Zfish   271 EAAPPASFPVGVISI----ITDRWRKTLR----QRVR---------------------------- 299

  Fly   333 YDAVFVLVEAFNRILRKKPDQFRSNHLQR----RSHGGSSSSSATGTNESSALLDCNTSKGWVTP 393
             :.|.::|:..:           |.|..|    ..|...||...:..|.|......|.|
Zfish   300 -EGVAIIVKGVH-----------SFHKHRGFIPEGHSDCSSPVKSYANNSLFRHMLNVS------ 346

  Fly   394 WEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSH 458
            ||.                 .::.|:.||...|.::.::.:...:...:|..:  :.|:|.:
Zfish   347 WEH-----------------KDLSFNSDGYLTNPSMVIIALDRENHWDKVGSY--EGGILQM--- 389

  Fly   459 NYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSL------------------KQYTYGESLVGN 505
            .|....|..|......|..| ..|::|.|.|::.:                  :|....||::|:
Zfish   390 RYPVWPRYGSFLEPVSDNRH-LTVATLEERPFVIVESVDPATGTCVRNTVPCRRQSNRTESIIGH 453

  Fly   506 DR------FEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAI 564
            ..      .:|:|.|:...|:..:...|::.||.:|.:|   :...|.|:||:||:..|.||:||
Zfish   454 TEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHG---KMVRGVWNGMIGEVFYKRADMAI 515

  Fly   565 SAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLY 629
            .::||..||..::|||.||:..|||:|:.:. ..|....:||.|.|..:|:.:.:..:.|..|..
Zfish   516 GSLTINEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 579

  Fly   630 FVTR-FPP--YEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAF 691
            ||.. |.|  |...:|       :|:.|    ||.|               ||:..|.|......
Zfish   580 FVFEYFSPVGYNRSLV-------SAKAP----GGPT---------------FTIGKSVWLLWGIV 618

  Fly   692 MQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ------ 749
            ......| .|.....:|...||.||.:|.::|||||||||:..|:.:..:....|...|
Zfish   619 FNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHY 683

  Fly   750 TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHT----------YDEGIRRVRQSKG 804
            ....:||:..|||....|.:...:|..|.:|.......::::          ||..:......|.
Zfish   684 PPFRFGTVPNGSTERNIRSNYPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYDAAVLNYMAGKD 748

  Fly   805 KYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIR 869
            :...||               |:..|:...|.|:|:|....|..::.::.|:|....:|:..|:.
Zfish   749 EGCKLV---------------TIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLE 798

  Fly   870 NKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            ..|.  ...|..::.....::|.:.|:||::|:|:..:.|:::|...|
Zfish   799 TVWL--SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	81/448 (18%)
		ANF_receptor	53..434	CDD:279440	78/425 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	111/445 (25%)
		Lig_chan	612..907	CDD:278489	71/314 (23%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	82/458 (18%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	112/448 (25%)
		NMDAR2_C	845..>932	CDD:313729	207/958 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590936
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740