DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grin3bb

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	1037	Identity:	210/1037 - (20%)
Similarity:	392/1037 - (37%)	Gaps:	251/1037 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLAYLHFICASSIF--------WPEFSSAQQQQQTVSLTEKIPLGAIF-EQGTDDVQSAFKYAM- 61
            ||||  |...|.||        .|..|..|.......:...:.|||:. .:.:..|::|...|:
Zfish     8 FLAY--FYLGSQIFLLHTLLLLQPAHSHPQPCHILARIGHTVRLGALLPPRQSVRVRAALHRALS 70

  Fly    62 ---------LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF-SRGVYSMLG-AVSPDSFD 115
                     |.:||::.....|.|       :.|...|.|.:|... .:||.::|. ..:.:...
Zfish    71 GLAESGNNFLPYNLSLDVVAREAQ-------SGDPESLFRCVCQDIVVQGVSAVLAFPQTQEEIV 128

  Fly   116 TLHSYSNTFQMPFVT------PWFPEK-------VLAPSSGLLD--FAISMRPDYHQAIIDTIQY 165
            .:...|:..::||::      |...:.       ...|.|||::  .|:..|..:.:::  .:..
Zfish   129 QMEFMSSFLEIPFISIIEHGEPLKTQNRFHLQMTTRIPPSGLVELLLAVLQRSGWEESM--AVLC 191

  Fly   166 YGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRI 230
            :||:..        |||.|.::......|...:.::....:::.|
Zfish   192 HGWEDA--------GLLDLLKLQGRFGWGPSQWHLRAALNLSHST-------------------- 228

  Fly   231 VLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAV 295
                 |.||      ::.|         :|.....:|:..|:.|:.|||       ..:.....:
Zfish   229 -----ARMA------NISD---------FLSEHFNLDHSPPASVLLFGA-------DPECASSVL 266

  Fly   296 RDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQ 360
            |..||....| |:......:...|::|.:|.....|:         |:..:..|..|.:.|:.||
Zfish   267 RSAHDLGLTL-PTVHWIMGHPLSPDALHSIGLPLGLL---------AYGEVDHKPLDFYISDALQ 321

  Fly   361 RRSHGGSSSSSATGTNESSALL----DCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421
            ..:.   :.::||......||:    :|............|:.|:|.|......||:|.:....:
Zfish   322 LINR---AVTAATVVRPDLALIQNMVNCFDKPNKHELPSSGQYIARFLSNTSFVGLTGPVIVQRN 383

  Fly   422 GRRI--NYTLHVVEMSVNS----TLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDR---- 476
            ..|:  ::.:|:..:..::    |...|..|  :.|.|.:........|.....:.|...|
Zfish   384 LSRVHTSHKVHIWSLRRDAVGQPTWVTVGSW--EGGRLNVEEQGLWQGSSPRQRTEGQMGREGRR 446

  Fly   477 --------NHTYIVSSLLEEPYLSLKQ-------------------------YTYGESLVGNDRF 508
                    .....|.:|:|.|::..::                         :.|.|...||..|
Zfish   447 WRAGFPVSGSRLRVVTLVEHPFVFTREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSF 511

  Fly   509 ---------EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGG-WDGMVGELIRKEADIA 563
                     .|||.||.:.|:..:..::::.:|.||.|||    ..|| |.|:||:|:...||:|
Zfish   512 LPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYGA----VKGGQWTGLVGDLLSGVADMA 572

  Fly   564 ISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVL 628
            :::.:|.:.|.:||||:.||.:..:.|:::......| :.:|:.||...:|:.:   :|.:....
Zfish   573 VTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTAAP-IGAFMWPLHWSMWMGI---FVALHITA 633

  Fly   629 YFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLA---- 689
            .|:|.   |||:            .|.|                :.|:....:..|.||.|
Zfish   634 LFLTL---YEWK------------SPFG----------------MTPHGRNRVKVFSYSSALNLC 667

  Fly   690 ---AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTM--- 748
               .|.:.....||....||....:|..|.::::|||||||||.:..|:....:....|..:
Zfish   668 YAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDAKLHHP 732

  Fly   749 QTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKY-ALLVES 812
            .....:||:...|..::.::|...:|    |||   :..:..|..:|:..::....:. |.:::.
Zfish   733 SQGFRFGTVRESSAEDYMKKSFPEMH----EYM---RKFNEPTTPDGVATLKTDPPQLDAFIMDK 790

  Fly   813 PKNEY-VNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWW--- 873
            ...:| |:....|..:.||:....:|:|:..|..|||...::|.|...|.:|.:..:.:||:
Zfish   791 ALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWYKVV 855

  Fly   874 ------FDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-FCRNKTPQLK 928
                  |..||         ..::.:.:.:|::.:|..|:..|::....|. |.|...|.::
Zfish   856 PCGKRVFAVTE---------TLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVLPHIR 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	80/449 (18%)
		ANF_receptor	53..434	CDD:279440	73/413 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	106/457 (23%)
		Lig_chan	612..907	CDD:278489	65/315 (21%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	84/477 (18%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	103/440 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840