Protein Alignment GluRIA and gria2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_031752085.1
• Gene: gria2 / 100216082
• XenbaseID: XB-GENE-966066
• Length: 937
• Species: Xenopus tropicalis
• Alignment Length: 1018
• Identity: 391/1018 - (38%)
• Similarity: 562/1018 - (55%)
• Gaps: 190/1018 - (18%)

  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101
            :..|.:|.:|.:|.|...|||:..||.:    |:..|.|..::|.:..|::|.::...|:|||||
 Frog    24 SNSIQIGGLFPRGADQEYSAFRVGMLLY----STSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166
            |:::.|.....|.:|:.|:..|..:.|:||.|      |:.|...|.|.||||...|::..|:||
 Frog    85 VFAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTDGTHPFVIQMRPDLKGALLSLIEYY 143

  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQ----------ELKPGN-------ETFRVQMVKRIANVTMAIE 214
            .|....|||||..||..||.:..          .:..||       ||:|
 Frog   144 QWDKFAYLYDSDRGLSTLQAVLDAAAEKKWQVTAINVGNINNDRKDETYR--------------- 193

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV--V 275
              ...:||....::|::|||..:...:|:.|   .|.:|:  :.|||:::.|...:   .|:  :
 Frog   194 --SLFQDLEIKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTD---GDLSKI 250

  Fly   276 EFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV 340
            :||..|::||:|||.:...|..|......||     :.:..|...:  .|...:||.:|||.|:.
 Frog   251 QFGGANVSGFQIVDYDDPLVAKFIQRWSTLE-----EKEYPGAHTT--TIKYTSALTFDAVQVMT 308

  Fly   341 EAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLR 405
            ||| |.|||:..:     :.||.:.|                ||..:.  ..||..|.:|.|.|:
 Frog   309 EAF-RNLRKQRIE-----ISRRGNAG----------------DCLANP--AVPWGHGVEIERALK 349

  Fly   406 KVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRD-DAGLLPLHSHNYASSSRSASA 469
            :|:::||||.|:||::|:|:|||::::|:..|.. :::..|.: |..::.:      :...||:.
 Frog   350 QVQVEGLSGNIKFDQNGKRVNYTINIMELKSNGP-RKIGYWSEVDKMVVTV------TDVLSAND 407

  Fly   470 STGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQD 534
            |.|  ..|.|.||:::||.||:..|:  ..:...||||:||||.|||..:|...|.||::.:|.|
 Frog   408 SMG--LENKTVIVTTILEAPYVMFKK--NADQFEGNDRYEGYCVDLAAEIARHCGFKYKLTIVAD 468

  Fly   535 GNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQT 599
            |.|||.:.... .|:||||||:..:|||||:.:|||..||.|||||||||:||||||||||.|..
 Frog   469 GKYGARDAETK-IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532

  Fly   600 PGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV-----RRPQADSTAQQPPGIIG 659
            |||||||:||:.|||:.::.:|:|||.||:.|:||.||||...     |..|::.::
 Frog   533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSNESS-------- 589

  Fly   660 GATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYT 724
                            |||.:.||.|:||.|||||||||:|.|::|||...||||||:|:|||||
 Frog   590 ----------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYT 638

  Fly   725 ANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHS 788
            |||||||||||||:||::.|||:.||::.||||..|||.||||||:|.:.:|||.|| :|.....
 Frog   639 ANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMKSAEPSVF 703

  Fly   789 VHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLN 853
            |.|..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|:|||..||||..:|
 Frog   704 VKTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKQSPLRNAVN 768

  Fly   854 EAVLTLKENGELLRIRNKWWFDKTECNL---DQETSTPN-------------------------- 889
            .|||.|.|.|.|.:::||||:||.||..   |.:.|..|
 Frog   769 LAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKVSPINLAVLKLSEQGVLDKLKNKWWYDKGEC 833

  Fly   890 ------------ELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAGGVPGM 942
                        .||||||||::|||:|||.||::||::||..:::
 Frog   834 GAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR------------------- 879

  Fly   943 LASSTYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVELASNV 985
             |.:...:..||| :|.::|:|::..|:..:.|:...|....|
 Frog   880 -AEAKRMKIYLSD-VMRNKARLSITGSTGENGRITTPEFPKAV 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	128/436 (29%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	222/407 (55%)
		Lig_chan	610..906	CDD:459656	162/342 (47%)
gria2	XP_031752085.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	128/434 (29%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	222/407 (55%)