DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and gria2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_031752085.1	Gene:	gria2 / 100216082	XenbaseID:	XB-GENE-966066	Length:	937	Species:	Xenopus tropicalis

Alignment Length:	1018	Identity:	391/1018 - (38%)
Similarity:	562/1018 - (55%)	Gaps:	190/1018 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101
            :..|.:|.:|.:|.|...|||:..||.:    |:..|.|..::|.:..|::|.::...|:|||||
Frog    24 SNSIQIGGLFPRGADQEYSAFRVGMLLY----STSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166
            |:::.|.....|.:|:.|:..|..:.|:||.|      |:.|...|.|.||||...|::..|:||
Frog    85 VFAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTDGTHPFVIQMRPDLKGALLSLIEYY 143

  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQ----------ELKPGN-------ETFRVQMVKRIANVTMAIE 214
            .|....|||||..||..||.:..          .:..||       ||:|
Frog   144 QWDKFAYLYDSDRGLSTLQAVLDAAAEKKWQVTAINVGNINNDRKDETYR--------------- 193

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV--V 275
              ...:||....::|::|||..:...:|:.|   .|.:|:  :.|||:::.|...:   .|:  :
Frog   194 --SLFQDLEIKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTD---GDLSKI 250

  Fly   276 EFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV 340
            :||..|::||:|||.:...|..|......||     :.:..|...:  .|...:||.:|||.|:.
Frog   251 QFGGANVSGFQIVDYDDPLVAKFIQRWSTLE-----EKEYPGAHTT--TIKYTSALTFDAVQVMT 308

  Fly   341 EAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLR 405
            ||| |.|||:..:     :.||.:.|                ||..:.  ..||..|.:|.|.|:
Frog   309 EAF-RNLRKQRIE-----ISRRGNAG----------------DCLANP--AVPWGHGVEIERALK 349

  Fly   406 KVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRD-DAGLLPLHSHNYASSSRSASA 469
            :|:::||||.|:||::|:|:|||::::|:..|.. :::..|.: |..::.:      :...||:.
Frog   350 QVQVEGLSGNIKFDQNGKRVNYTINIMELKSNGP-RKIGYWSEVDKMVVTV------TDVLSAND 407

  Fly   470 STGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQD 534
            |.|  ..|.|.||:::||.||:..|:  ..:...||||:||||.|||..:|...|.||::.:|.|
Frog   408 SMG--LENKTVIVTTILEAPYVMFKK--NADQFEGNDRYEGYCVDLAAEIARHCGFKYKLTIVAD 468

  Fly   535 GNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQT 599
            |.|||.:.... .|:||||||:..:|||||:.:|||..||.|||||||||:||||||||||.|..
Frog   469 GKYGARDAETK-IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532

  Fly   600 PGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV-----RRPQADSTAQQPPGIIG 659
            |||||||:||:.|||:.::.:|:|||.||:.|:||.||||...     |..|::.::
Frog   533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSNESS-------- 589

  Fly   660 GATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYT 724
                            |||.:.||.|:||.|||||||||:|.|::|||...||||||:|:|||||
Frog   590 ----------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYT 638

  Fly   725 ANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHS 788
            |||||||||||||:||::.|||:.||::.||||..|||.||||||:|.:.:|||.|| :|.....
Frog   639 ANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMKSAEPSVF 703

  Fly   789 VHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLN 853
            |.|..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|:|||..||||..:|
Frog   704 VKTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKQSPLRNAVN 768

  Fly   854 EAVLTLKENGELLRIRNKWWFDKTECNL---DQETSTPN-------------------------- 889
            .|||.|.|.|.|.:::||||:||.||..   |.:.|..|
Frog   769 LAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKVSPINLAVLKLSEQGVLDKLKNKWWYDKGEC 833

  Fly   890 ------------ELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAGGVPGM 942
                        .||||||||::|||:|||.||::||::||..:::
Frog   834 GAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR------------------- 879

  Fly   943 LASSTYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVELASNV 985
             |.:...:..||| :|.::|:|::..|:..:.|:...|....|
Frog   880 -AEAKRMKIYLSD-VMRNKARLSITGSTGENGRITTPEFPKAV 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	128/433 (30%)
		ANF_receptor	53..434	CDD:279440	120/401 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	222/407 (55%)
		Lig_chan	612..907	CDD:278489	163/341 (48%)
gria2	XP_031752085.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	128/434 (29%)
gria2	XP_031752085.1	PBP2_iGluR_AMPA	413..794	CDD:270433	222/407 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	715	1.000	Inparanoid score	I630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm9529
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060