DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and si:dkey-183j2.10

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_001923977.1	Gene:	si:dkey-183j2.10 / 100151589	ZFINID:	ZDB-GENE-130530-729	Length:	465	Species:	Danio rerio

Alignment Length:	445	Identity:	142/445 - (31%)
Similarity:	242/445 - (54%)	Gaps:	50/445 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 IVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAP 545
            ||:::.::||...|          ..:.||||.||...||.:||.||::.||:||:||.:::  .
Zfish    32 IVTTIKQDPYTMSK----------GSQLEGYCMDLLTELAKKLGFKYKVHLVKDGSYGRQDE--N 84

  Fly   546 GGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKP-VKQTPGVFSFLNPL 609
            |.|:||:||::|.|||:|::.:|:||.||:.:..:||:|..||||:::|. |.:..|.|.||:|.
Zfish    85 GNWNGMIGEVVRGEADLAVAPLTLTAAREKAVGMTKPYMQTGISILLRKDIVSEEAGFFDFLSPF 149

  Fly   610 SQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVP 674
            |.|.|..::::|...:..:..|.|..|.||                        |:|:..
Zfish   150 SGETWFGILIAYFVTAVCICIVGRLSPCEW------------------------SQPETE----- 185

  Fly   675 PNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAP 739
            ||.||:|:|.||:..|...||....|.:::||:.:..||.|.::|::.|.::|::....:.....
Zfish   186 PNHFTLLHSLWYTAGALSLQGAGPHPKAVSGRVISCTWWLFAVVLLACYFSSLSSTQGSDSAPLM 250

  Fly   740 IKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKG 804
            ||..|||..|..:.||||...||..||:.|....:.:::|:|...:.. |.:.|||:::.::  |
Zfish   251 IKGFEDLANQDVIEYGTLAGSSTLAFFKNSNNPSYRRIYEHMERRKSF-VSSMDEGVQKAKE--G 312

  Fly   805 KYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIR 869
            .||.:.||...:...|| .|:.::....|..:|:.:.||:||.:.|.|:.|:|.|.|.|||..:|
Zfish   313 NYAFIGESVSLDLAVAR-HCELVRAHEVIGMRGYSIVTPLGSAMLKNLSVAILQLSEAGELAYLR 376

  Fly   870 NKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKT 924
            .|||  .:.|..|  .:..:.|...::.||:.:|..||.:.|::::.|...::::
Zfish   377 TKWW--ASSCLPD--NAKASSLRAHSMKGIFLVLAIGLGIGVLLSLFELTTKSRS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	132/398 (33%)
		Lig_chan	612..907	CDD:278489	84/294 (29%)
si:dkey-183j2.10	XP_001923977.1	PBP2_iGluR_non_NMDA_like	28..381	CDD:270403	132/395 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810