DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and gria3

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	946	Identity:	394/946 - (41%)
Similarity:	546/946 - (57%)	Gaps:	98/946 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QQQQQTVSL-------------TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSS--RRFELQA 77
            |.:.|||.|             ...|.:|.:|.:.|....|||.:|:..||.|.::  |.|:|..
Frog     3 QNEVQTVFLLLLSLVGESCGGFPNTINIGGLFMRNTIQEHSAFLFAVQLHNTNQNNTERPFQLFH 67

  Fly    78 YVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSS 142
            :||.::::::|.::...|:|||||||::.|.....|.:||.|:.......|:||.|      |:.
Frog    68 HVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFITPSF------PTD 126

  Fly   143 GLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIA 207
            ..:.|.|.|||....||:..:..|.||..:||||:..|...||.|.:.....|.....:.|..|.
Frog   127 ADVQFVIQMRPPLKGAILTLLNEYDWQKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIK 191

  Fly   208 NVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLSGLVMDNHW 270
            :|.   ||...:|::.|..:||.|:||..|....|:.|.|   .||:.|  |||:|:.|......
Frog   192 DVQ---EFKRIIEEMDRRQEKRFVIDCEVERINTILEQVV---ILGKHTRGYHYMLANLGFTGFT 250

  Fly   271 PSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDA 335
            ...|:..|| |:|||:||::....|:.|.....||:.....:::|.       .:...:||.:||
Frog   251 LERVMHGGA-NVTGFQIVNNENPIVQQFLQRWVRLDEREFPEARNT-------PLKYTSALTHDA 307

  Fly   336 VFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKI 400
            |.|:.|||..:.|::.|      :.||...|                ||..:.  ..||.||..|
Frog   308 VLVIAEAFRYLRRQRVD------VSRRGSAG----------------DCLANP--AVPWSQGIDI 348

  Fly   401 SRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSR 465
            .|.|:.|::.|::|.|:||..|||.|||:.|.||:.... ::|..|.:....:|.......:.|.
Frog   349 ERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMTATKP-RKVGHWNEYERFVPAPDQQPTNESS 412

  Fly   466 SASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIR 530
            |.        .|.|.||:::||.||:..|:  ..|.|.|||::||||.|||..:|..:||||::.
Frog   413 SV--------ENKTIIVTTILENPYVMKKK--NHELLDGNDKYEGYCVDLASEIAKHVGIKYKLS 467

  Fly   531 LVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKP 595
            :|:||.|||.:.... .|:||||||:...||||::.:|||..||.|||||||||:||||||||||
Frog   468 IVEDGKYGARDPETK-IWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKP 531

  Fly   596 VKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGG 660
            .|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||.:....:|
Frog   532 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDTDEA------------- 583

  Fly   661 ATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTA 725
               .:||.  ||.|||||.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||
Frog   584 ---RDPQN--PPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 643

  Fly   726 NLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSV 789
            ||||||||||||:||::.|||..||::.||||..|||.||||||:|.::.|||.|| :|......
Frog   644 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFT 708

  Fly   790 HTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNE 854
            .|.|:|:.|||:||||:|.|:||..|||:..|.||||||||.|:|:||:|||||.||.|...:|.
Frog   709 KTTDDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNL 773

  Fly   855 AVLTLKENGELLRIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            |||.|.|.|.|.:::||||:||.||......|  ..:.||||||||::|||:|||.||::||::|
Frog   774 AVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 838

  Fly   918 FFCRNKTPQLKSPGSNGSAGGVPGMLAS----STYQ 949
            |..:::....:...:..:....|...||    :||:
Frog   839 FCYKSRAESKRMKLTKNAQNFKPPPAASTQNYATYR 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	131/415 (32%)
		ANF_receptor	53..434	CDD:279440	124/384 (32%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	226/402 (56%)
		Lig_chan	612..907	CDD:278489	164/297 (55%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	131/415 (32%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	226/402 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	715	1.000	Inparanoid score	I630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm9529
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.190