Protein Alignment GluRIA and gria1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_004912781.1
• Gene: gria1 / 100127569
• XenbaseID: XB-GENE-995621
• Length: 903
• Species: Xenopus tropicalis
• Alignment Length: 971
• Identity: 387/971 - (39%)
• Similarity: 564/971 - (58%)
• Gaps: 123/971 - (12%)

  Fly    34 VSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF 98
            |:....|.:|.:|........:||::|     |:..|...:|...:|::|.:|:|:::...|:||
 Frog    19 VNFPNHIQIGGLFPNQQSQEHAAFRFA-----LSQLSEPPKLLPQIDIVNISDSFEMTYTFCSQF 78

  Fly    99 SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTI 163
            |:|||::.|.....:.:.|.|:.....:.|:||.||   :|.|:   .|.:.:||:...|:|..|
 Frog    79 SKGVYAIFGFYDRKTVNMLTSFCGALHVCFITPSFP---VATSN---QFVLQLRPELQDALISVI 137

  Fly   164 QYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKK 228
            :||.|:..:|:||:..||..||::.......|  ::|..|..:.........|  .:||.:...:
 Frog   138 EYYKWKKFVYIYDADRGLSVLQKVLDTAAEKN--WQVTAVNILTTTEEGYRLL--FQDLDKSKDR 198

  Fly   229 RIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLSGL-VMDNHWPSDVVEF---GAINITGFRI 287
            :||:||.:|....|:.|.|  :||.:..  |||:|:.| .||    .|:.:|   || |:|||::
 Frog   199 QIVIDCESERLNAILTQVV--VKLEKNIIGYHYILANLGFMD----IDMQKFKEAGA-NVTGFQL 256

  Fly   288 VDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQ-----AALMYDAVFVLVEAFNRIL 347
            |:.....|.......|..:  |:.|          |.:..:     :||.||.|.|:.|||..:.
 Frog   257 VNYTDTMVSRIMQQWKNYD--GREQ----------PRVDWKKPKYTSALTYDGVRVMAEAFQSLR 309

  Fly   348 RKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL 412
            :::.|      :.||.:.|                ||..:.  ..||.||..|.|.|::|.::||
 Frog   310 KQRID------ISRRGNAG----------------DCLANP--AVPWGQGIDIQRALQQVRLEGL 350

  Fly   413 SGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRN 477
            ||.::|:|.|||.||||||:|:. :..::.:|.|.:|..|:||     |:.:::.:.:.|  .:|
 Frog   351 SGNVQFNEKGRRTNYTLHVLELK-HEGIRHIAHWNEDDKLIPL-----ATDAQAGNDTIG--VQN 407

  Fly   478 HTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQ 542
            .||||:::||.||:.||:  ..:.|.|||||||||.:||..:|..:|.||::.:|:||.|||.:.
 Frog   408 RTYIVTTILEAPYVMLKK--NADQLEGNDRFEGYCVELAAEIAKHVGFKYKLEIVKDGKYGARDS 470

  Fly   543 YAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLN 607
            ... .|:||||||:...||:|::.:|||..||.|||||||||:||||||||||.|..|||||||:
 Frog   471 DMK-AWNGMVGELVYGRADLAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 534

  Fly   608 PLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPP 672
            ||:.|||:.::.:|:|||.||:.|:||.||||   ...:.:...:||       |..:
 Frog   535 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW---HNEEFEEGKEQP-------TTDQ------- 582

  Fly   673 VPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMV 737
              .|||.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||
 Frog   583 --SNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 645

  Fly   738 APIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQ 801
            :||::.:||..||::.||||..|||.|||:||:|.:..|||.|| :|.....|.|.:||:.|||:
 Frog   646 SPIESADDLAKQTEIAYGTLDSGSTKEFFKRSKIAVFEKMWTYMRSAEPSVFVKTTEEGMNRVRK 710

  Fly   802 SKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELL 866
            ||||||.|:||..|||:..|.||||||||.|:|:||:|:|||.|||||..:|.|||.|.|.|.|.
 Frog   711 SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRGAVNLAVLKLSEQGVLD 775

  Fly   867 RIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKS 929
            ::::|||:||.||......|  ..:.||||||||::|||||||.||::||::||..::::...|.
 Frog   776 KLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKKM 840

  Fly   930 PG---------------------SNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQAS 969
            .|                     |.....|..|.:.|..:.:...:...|...|.:|:.|:
 Frog   841 KGFCLIPQTTVTETVRMATLPRPSTAGGSGENGRVVSHDFPKTMQTIPCMSHGAGMALGAT 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	126/425 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	222/402 (55%)
		Lig_chan	610..906	CDD:459656	160/298 (54%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	127/430 (30%)
		PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	222/402 (55%)