DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and gria1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_004912781.1	Gene:	gria1 / 100127569	XenbaseID:	XB-GENE-995621	Length:	903	Species:	Xenopus tropicalis

Alignment Length:	971	Identity:	387/971 - (39%)
Similarity:	564/971 - (58%)	Gaps:	123/971 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF 98
            |:....|.:|.:|........:||::|     |:..|...:|...:|::|.:|:|:::...|:||
Frog    19 VNFPNHIQIGGLFPNQQSQEHAAFRFA-----LSQLSEPPKLLPQIDIVNISDSFEMTYTFCSQF 78

  Fly    99 SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTI 163
            |:|||::.|.....:.:.|.|:.....:.|:||.||   :|.|:   .|.:.:||:...|:|..|
Frog    79 SKGVYAIFGFYDRKTVNMLTSFCGALHVCFITPSFP---VATSN---QFVLQLRPELQDALISVI 137

  Fly   164 QYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKK 228
            :||.|:..:|:||:..||..||::.......|  ::|..|..:.........|  .:||.:...:
Frog   138 EYYKWKKFVYIYDADRGLSVLQKVLDTAAEKN--WQVTAVNILTTTEEGYRLL--FQDLDKSKDR 198

  Fly   229 RIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLSGL-VMDNHWPSDVVEF---GAINITGFRI 287
            :||:||.:|....|:.|.|  :||.:..  |||:|:.| .||    .|:.:|   || |:|||::
Frog   199 QIVIDCESERLNAILTQVV--VKLEKNIIGYHYILANLGFMD----IDMQKFKEAGA-NVTGFQL 256

  Fly   288 VDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQ-----AALMYDAVFVLVEAFNRIL 347
            |:.....|.......|..:  |:.|          |.:..:     :||.||.|.|:.|||..:.
Frog   257 VNYTDTMVSRIMQQWKNYD--GREQ----------PRVDWKKPKYTSALTYDGVRVMAEAFQSLR 309

  Fly   348 RKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL 412
            :::.|      :.||.:.|                ||..:.  ..||.||..|.|.|::|.::||
Frog   310 KQRID------ISRRGNAG----------------DCLANP--AVPWGQGIDIQRALQQVRLEGL 350

  Fly   413 SGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRN 477
            ||.::|:|.|||.||||||:|:. :..::.:|.|.:|..|:||     |:.:::.:.:.|  .:|
Frog   351 SGNVQFNEKGRRTNYTLHVLELK-HEGIRHIAHWNEDDKLIPL-----ATDAQAGNDTIG--VQN 407

  Fly   478 HTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQ 542
            .||||:::||.||:.||:  ..:.|.|||||||||.:||..:|..:|.||::.:|:||.|||.:.
Frog   408 RTYIVTTILEAPYVMLKK--NADQLEGNDRFEGYCVELAAEIAKHVGFKYKLEIVKDGKYGARDS 470

  Fly   543 YAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLN 607
            ... .|:||||||:...||:|::.:|||..||.|||||||||:||||||||||.|..|||||||:
Frog   471 DMK-AWNGMVGELVYGRADLAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 534

  Fly   608 PLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPP 672
            ||:.|||:.::.:|:|||.||:.|:||.||||   ...:.:...:||       |..:
Frog   535 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW---HNEEFEEGKEQP-------TTDQ------- 582

  Fly   673 VPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMV 737
              .|||.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||
Frog   583 --SNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 645

  Fly   738 APIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQ 801
            :||::.:||..||::.||||..|||.|||:||:|.:..|||.|| :|.....|.|.:||:.|||:
Frog   646 SPIESADDLAKQTEIAYGTLDSGSTKEFFKRSKIAVFEKMWTYMRSAEPSVFVKTTEEGMNRVRK 710

  Fly   802 SKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELL 866
            ||||||.|:||..|||:..|.||||||||.|:|:||:|:|||.|||||..:|.|||.|.|.|.|.
Frog   711 SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRGAVNLAVLKLSEQGVLD 775

  Fly   867 RIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKS 929
            ::::|||:||.||......|  ..:.||||||||::|||||||.||::||::||..::::...|.
Frog   776 KLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKKM 840

  Fly   930 PG---------------------SNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQAS 969
            .|                     |.....|..|.:.|..:.:...:...|...|.:|:.|:
Frog   841 KGFCLIPQTTVTETVRMATLPRPSTAGGSGENGRVVSHDFPKTMQTIPCMSHGAGMALGAT 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	124/422 (29%)
		ANF_receptor	53..434	CDD:279440	118/391 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	222/402 (55%)
		Lig_chan	612..907	CDD:278489	161/297 (54%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	127/430 (30%)
gria1	XP_004912781.1	PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	222/402 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	715	1.000	Inparanoid score	I630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm9529
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060