Protein Alignment GluRIA and grid1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001096470.1
• Gene: grid1 / 100125089
• XenbaseID: XB-GENE-990290
• Length: 1009
• Species: Xenopus tropicalis
• Alignment Length: 956
• Identity: 265/956 - (27%)
• Similarity: 433/956 - (45%)
• Gaps: 181/956 - (18%)

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAY-VDVINTADAFKLSRLICNQFSRGVY 103
            |.:|||||:........|:.|:.:.:||....:.|...| :..|...:.|:..:..|:..::|:.
 Frog    24 IHIGAIFEENAVKDDEVFQLAVSDLSLNDDILQSEKITYSIKFIEANNPFQAVQEACDLMTQGIL 88

  Fly   104 SMLGAVSPDSFDTLHSYSNTFQMPFV-----TPWFPEKV--LAPSSGLLDFAISMRPD--YHQAI 159
            :::.:....|.:.|.|.::...:|.:     :...|..|  ..||....::.::.||.  .:..:
 Frog    89 ALVTSTGCASANALQSLTDAMHIPHIFVQRNSGGSPRTVCQFNPSPEGEEYTLAARPPVRLNDVM 153

  Fly   160 IDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHT---LED 221
            :..:....||..|..|||...:..||....:.........:|.|.|  |::.....|.|   .|:
 Frog   154 LKLVTELRWQKFIVFYDSDYDIRGLQGFLDQASRLGLDVSLQKVDR--NISRVFATLFTSMKTEE 216

  Fly   222 LGRF--SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHW--------PSDVVE 276
            |.|:  :.:|.:|......|:..|.:.| :..|..:           |:||        .:::||
 Frog   217 LNRYRDTLRRAILLLSPRGAQSFISEAV-ETNLASK-----------DSHWVYVNEEINDAEIVE 269

  Fly   277 F--GAI-NITGFR-----IVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAAL-- 331
            .  .|: .||..|     :.|:|.|.||:.|    |:.              |||....:..|
 Frog   270 LVHSALGRITVIRQIFPSLKDNNIRCVRNNH----RIA--------------SLPCDPQEGYLQM 316

  Fly   332 -------MYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKG 389
                   :||:|.:|..||:|.|.           .|:.|             |.|.|:|....
 Frog   317 LQVSNLYLYDSVLMLANAFHRKLE-----------DRKWH-------------SMASLNCMRKS- 356

  Fly   390 WVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNST----LQQVAEWRDDA 450
             ..||..|..:...::|..|.||:|.:.|.|.|...:....::..|.:.|    ::::|.|
 Frog   357 -TKPWNGGRSMLDTIKKGRITGLTGIMEFKEAGANPHVQFEILGTSYSETFGKDVRRLATW---- 416

  Fly   451 GLLPLHSHNYASSSRSASASTGDYDRNH-----TYIVSSLLEEPYLSLKQYTYGESLVGN-DRFE 509
                       .|.:..:.|..:...|:     |..|.::||||::.:     .|:::|. .|::
 Frog   417 -----------DSMKGFNGSLQEKPLNNDLQGLTLKVVTVLEEPFVMV-----AENILGQPKRYK 465

  Fly   510 GYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERE 574
            |:..::.|.|:.:||.||||....||.||  :|.:.|.|:||:||||.|.|||||||:|||.|||
 Frog   466 GFSIEILDELSNRLGFKYEIYQAPDGKYG--HQLSNGSWNGMIGELINKRADIAISAITITPERE 528

  Fly   575 RVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW--ISVILSYVGVSFVLYFVTRFPPY 637
            .|:||:|.::...:.|:|||| ::...:||...|....:|  |:.::..|||  :::.:.|.
 Frog   529 NVVDFTKRYLDYSVGILIKKP-EERINIFSLFAPFDFAVWACIAAVIPVVGV--LIFVLNRI--- 587

  Fly   638 EWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPS 702
              :.||...:..|:|        :|.|              |:.::.|....||:|||.:....|
 Frog   588 --QAVRAQNSSQTSQ--------STSS--------------TLHSAIWIVYGAFVQQGGESAANS 628

  Fly   703 IAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFR 767
            :|.||....||.||:|:.|||||||||||||.||..||:|.:||..|.|:.|||:...|.:|:|:
 Frog   629 VAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLAKQVDLPYGTVKDSSVYEYFK 693

  Fly   768 RS------QIGLHNKMWEYMNAN--QHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN-ARPP 823
            ..      |.....::|..:..|  ..:.|.:..||||:.:  :|.||.|.:....||.. ....
 Frog   694 SKGTNTLVQDRTFAELWRTIGKNNGSDNCVSSPSEGIRKAK--RGNYAFLWDVTVVEYAALTDDE 756

  Fly   824 CDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTP 888
            |.....|..|.:||:|:|...|||.|...::.:|..:::|.|..::.|||.....|:|:...:..
 Frog   757 CSVAVTGNTISSKGYGIALQHGSPYRDIFSQRILEFQDSGRLDVLKEKWWPRTGRCDLNSHNNAQ 821

  Fly   889 NE---LSLSNVAGIYYILIGGLLLAVIVAIMEFF-----CRNKTPQ 926
            |:   |.|.:.||::.||..|||||.:||.:|.:     ||..:|:
 Frog   822 NDGKALKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCRQDSPK 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	97/458 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	145/418 (35%)
		Lig_chan	610..906	CDD:459656	96/309 (31%)
grid1	NP_001096470.1	PBP1_iGluR_delta_1	25..426	CDD:380615	98/473 (21%)
		PBP2_iGluR_delta_1	437..807	CDD:270448	143/408 (35%)