DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and grin2ca

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001352716.1	Gene:	grin2ca / 100003342	ZFINID:	ZDB-GENE-070822-3	Length:	1400	Species:	Danio rerio

Alignment Length:	928	Identity:	194/928 - (20%)
Similarity:	346/928 - (37%)	Gaps:	235/928 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 ELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMPFVTPW 132
            |:.....::|..:...|...||:..:..  .:.|.|..|:..:      |...|....:|.|...
Zfish    70 EVNPITVLVNNTNPRTLLTRICDTLAAN--RVHGVVFEDNIGSEAVAQILDFISTQTAVPIVGIS 132

  Fly   133 FPEKVLAPSSG----LLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKP 193
            ....|:.|..|    .|....|:....: .:...::.|.|.|.:              :...|.|
Zfish   133 GGSAVVLPHKGDGSTFLQLGSSIEQQIN-GMFKVMEEYNWDSFV--------------VVTSLYP 182

  Fly   194 GNETFRVQMVKRIANVTMAIEFLHTLEDLGRFS----------KKRIVLDCPAEM--------AK 240
            |.:|: |..::...:.:.   ||..|:|...|.          .:|::....|::        ..
Zfish   183 GYDTY-VDYIRSFIDTSY---FLWELQDTLTFDMSADGMNDLRARRLLQQIDAQVLLVYCSHDEA 243

  Fly   241 EIIVQHVRDIKLGRRTYHYLLSGLVMDNH--WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRK 303
            :.:....|::.|....|.:.:..|.:.|.  .|.|....|.|:|...|...|.|..||
Zfish   244 QYLFSMAREVGLVGPGYIWFIPSLAVGNPNIAPPDSFPVGLISIITDRWKMSLRNRVR------- 301

  Fly   304 RLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKK---PDQFRSNHLQRRSHG 365
                                          |.|.::|:......:::   ||          .|
Zfish   302 ------------------------------DGVAIVVKGVESFRKQRGFIPD----------GH- 325

  Fly   366 GSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLH 430
                            :||.:.   :.|...|.....:|   .:...:.:..|:.||..:|.::.
Zfish   326 ----------------MDCLSP---IRPASNGTLYRHML---NVSWENTDFSFNSDGYLVNPSMI 368

  Fly   431 VVEMSVNSTLQQVAEW----RDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYL 491
            ::      ||.:..:|    ..::|:|.:   .|....|..:......|..| ..|::|.|.|::
Zfish   369 II------TLDRGRQWDKVGNYESGILQM---RYPVWPRYGTFLEPVSDNRH-LTVATLEERPFV 423

  Fly   492 SL------------------KQYTYGESLVGNDR------FEGYCKDLADMLAAQLGIKYEIRLV 532
            .:                  :|....|::||:..      .:|:|.|:...|:..:...|::.||
Zfish   424 IVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYTKLCCKGFCIDILKKLSRNIKFSYDLYLV 488

  Fly   533 QDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVK 597
            .:|.:|   :...|.|:||:||:..|.||:||.::||..||..:||||.||:..|||:|:.:. .
Zfish   489 TNGKHG---KLVRGIWNGMIGEVFYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARS-N 549

  Fly   598 QTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRF-PP--YEWRIVRRPQADSTAQQPPGIIG 659
            .|....:||.|.|..:|:.:.:..:.|..|..||..: .|  |...:|       :|:.|    |
Zfish   550 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYCSPVGYNRSLV-------SAKDP----G 603

  Fly   660 GATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSY 723
            |.|               ||:..|.|............| .|.....:|...||.||.:|.::||
Zfish   604 GPT---------------FTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASY 653

  Fly   724 TANLAAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMN 782
            |||||||:..|:.:..:....|...|      ....:||:..|||....|.:...:|:.|.:|
Zfish   654 TANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIRSNYPEMHSHMVKY-- 716

  Fly   783 ANQH------HSVHT-------YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNID 834
             ||.      :|:.|       ||..:......|.:...||               |:..|:...
Zfish   717 -NQKGVEDALNSLKTGKLDAFIYDAAVLNYMAGKDEGCKLV---------------TIGSGKVFA 765

  Fly   835 TKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGI 899
            |.|:|:|....|..::.::.|:|....:|:..:::..|.  ...|..:::....::|.:.|:||:
Zfish   766 TTGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVWL--TGICRNEKKEVMSSKLDIDNMAGV 828

  Fly   900 YYILIGGLLLAVIVAIME 917
            :|:|:..:.|:::|...|
Zfish   829 FYMLLVAMGLSLLVFAWE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	66/415 (16%)
		ANF_receptor	53..434	CDD:279440	62/392 (16%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	114/448 (25%)
		Lig_chan	612..907	CDD:278489	73/317 (23%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	68/427 (16%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	115/451 (25%)
		NMDAR2_C	847..>938	CDD:313729	194/928 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740