DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axed and BTBD6

DIOPT Version :9

Sequence 1:	NP_001356975.1	Gene:	axed / 38741	FlyBaseID:	FBgn0035708	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001374496.1	Gene:	BTBD6 / 90135	HGNCID:	19897	Length:	538	Species:	Homo sapiens

Alignment Length:	345	Identity:	80/345 - (23%)
Similarity:	123/345 - (35%)	Gaps:	93/345 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SAPAPSAPPAHMMPPAYARGQTNIYTGVPIIVNPYIDFIVVNGDDRYMIRCERKSVLERSV---- 181
            |||||:.||....||....                      |..:....||.|.::.||:.
Human    89 SAPAPAPPPPAPAPPTLGN----------------------NHQESPGWRCCRPTLRERNALMFN 131

  Fly   182 -ELAKLIH---AGPNSGRKSDNHFQILNVDKNDFELIVRYMEKHFIPYRDHKHLLKILELSDRFN 242
             ||...:|   ..|.:.|....|..:|.|..:.|         :.:.|.|      :.|:....:
Human   132 NELMADVHFVVGPPGATRTVPAHKYVLAVGSSVF---------YAMFYGD------LAEVKSEIH 181

  Fly   243 VPDLIIYCIRELDLRISSATALDIFKALWFYQGIALTNQHQTVITTQETGQQLARKKATKAKAAA 307
            :||            :..|..|.:.|.::..:   :..:..||:.|              ..||.
Human   182 IPD------------VEPAAFLILLKYMYSDE---IDLEADTVLAT--------------LYAAK 217

  Fly   308 KQL--AAAKASQS-TENGAEGDGA-----QQNLIPNPNPFTTEDYGVALLHNTLQLIDMHAELQL 364
            |.:  |.|||..: .|...|...|     |..|...|.          |.....::||..||:.|
Human   218 KYIVPALAKACVNFLETSLEAKNACVLLSQSRLFEEPE----------LTQRCWEVIDAQAEMAL 272

  Fly   365 SMPEISDLRFEELETLVKRDTLQLRSEVTLFECLATWSLAECARKHIDATPENRRTVLGPLCLTP 429
            ......::..:.||.:|.|:.|..: |..:||.:..|:.|||.|:.:..||.|:|.|||......
Human   273 RSEGFCEIDRQTLEIIVTREALNTK-EAVVFEAVLNWAEAECKRQGLPITPRNKRHVLGRALYLV 336

  Fly   430 RYLRMTASEFRRCCERLELL 449
            |...||..||.....:.::|
Human   337 RIPTMTLEEFANGAAQSDIL 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axed	NP_001356975.1	BTB	<192..258	CDD:197585	10/65 (15%)
axed	NP_001356975.1	BACK	<354..423	CDD:355779	23/68 (34%)
BTBD6	NP_001374496.1	BTB_POZ_BTBD6	128..236	CDD:349658	28/151 (19%)
		BACK_BTBD6	236..330	CDD:350600	29/104 (28%)
		PHR	392..537	CDD:400388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45774
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910