DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axed and btbd2a

DIOPT Version :9

Sequence 1:	NP_001356975.1	Gene:	axed / 38741	FlyBaseID:	FBgn0035708	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001038557.1	Gene:	btbd2a / 565970	ZFINID:	ZDB-GENE-030829-3	Length:	595	Species:	Danio rerio

Alignment Length:	365	Identity:	85/365 - (23%)
Similarity:	126/365 - (34%)	Gaps:	112/365 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 AIQSAPAPSAPPAHMMPPAYARGQTNIYTGVPIIVNPYIDFIVVNGDDRYMIRCERKSVLERSVE 182
            |..||.|.:|.....:|.:.|.                   ::|..:..|..:..:.:|.||...
Zfish   134 ASSSADASAAAAVSSLPSSPAS-------------------VLVYREPVYNWQATKSTVKERFAF 179

  Fly   183 LAKLIHAGPNSGRKSDNHFQILNVDKNDFELIVRYMEKHFIPYRDHKHLLKI------------- 234
            |.       |:...||.||           |:.:.|....||  .|:..|.:
Zfish   180 LF-------NNEVLSDVHF-----------LVGKGMGVQRIP--AHRFALAVGSAVFDAMFNGGM 224

  Fly   235 LELSDRFNVPDLIIYCIRELDLRISSATALDIFKALWFYQGIALTNQHQ----TVITTQETGQQL 295
            ...|....:||            :..|..|.:.|.|:       :::.|    ||:||..|
Zfish   225 ATTSTEIELPD------------VEPAAFLALLKFLY-------SDEVQIGPETVMTTLYT---- 266

  Fly   296 ARKKATKAKAA------AKQLAAAKASQSTENGAEGDGAQQNLIPNPNPFTTEDYGVALLHNTLQ 354
            |:|.|..|..|      .|.|.|..|....        .|..|...|.          |....|:
Zfish   267 AKKYAVPALEAHCVEFLKKNLRADNAFMLL--------TQARLFDEPQ----------LASLCLE 313

  Fly   355 LIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRSEVTLFECLATWSLAECARKHIDATPENRR 419
            .||.:....|:....:|:..:.|..:::||||.:| ||.||.....|:.||..|:.:..||||:|
Zfish   314 NIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVR-EVRLFGAAVRWAEAEAQRQQLQPTPENKR 377

  Fly   420 TVLGPLCLTPRYLRMTASEFRRCCERLELLPPTEISLITD 459
            .|||......|:..||..||        ...|.:..::||
Zfish   378 RVLGKALALIRFPLMTIEEF--------AAGPAQSGILTD 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axed	NP_001356975.1	BTB	<192..258	CDD:197585	14/78 (18%)
axed	NP_001356975.1	BACK	<354..423	CDD:355779	24/68 (35%)
btbd2a	NP_001038557.1	BTB	180..284	CDD:279045	30/146 (21%)
		BTB	188..287	CDD:197585	28/134 (21%)
		BACK	299..398	CDD:197943	35/117 (30%)
		PHR	446..593	CDD:285277
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810