DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axed and BTBD1

DIOPT Version :9

Sequence 1:	NP_001356975.1	Gene:	axed / 38741	FlyBaseID:	FBgn0035708	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_079514.1	Gene:	BTBD1 / 53339	HGNCID:	1120	Length:	482	Species:	Homo sapiens

Alignment Length:	424	Identity:	91/424 - (21%)
Similarity:	132/424 - (31%)	Gaps:	147/424 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LGP--DGHHVDAIQSAPAPSAPPAHMMPPAYARGQTNIYTGVPIIVNPYIDFIVVNGDDRYMIRC 171
            |||  .|......::.|.|:.||.   ||:            |..:.|   .:.:..:..|..:.
Human     4 LGPAAAGEQASGAEAEPGPAGPPP---PPS------------PSSLGP---LLPLQREPLYNWQA 50

  Fly   172 ERKSVLERSVELAKLIHAGPNSGRKSDNHFQILNVDKNDFELIVRYMEKHFIPYRDHKHLLKILE 236
            .:.|:.||...|.       ||...||..|.:   .|.      |.......|.|...|
Human    51 TKASLKERFAFLF-------NSELLSDVRFVL---GKG------RGAAAAGGPQRIPAH------ 93

  Fly   237 LSDRFNVPDLIIYCIRELDLRISSATALDIFKALWFYQGIALTNQH------------------- 282
                                |...|....:|.|: |..|:|.|:..
Human    94 --------------------RFVLAAGSAVFDAM-FNGGMATTSAEIELPDVEPAAFLALLRFLY 137

  Fly   283 --------QTVITTQETGQQLARKKATKAKAA------AKQLAAAKASQSTENGAEGDGAQQNLI 333
                    :||:||..|    |:|.|..|..|      .|.|.|..|....        .|..|.
Human   138 SDEVQIGPETVMTTLYT----AKKYAVPALEAHCVEFLTKHLRADNAFMLL--------TQARLF 190

  Fly   334 PNPNPFTTEDYGVALLHNTLQLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRSEVTLFECL 398
            ..|.          |....|..||......:|....:|:..:.|..:::||||.:| |..||..:
Human   191 DEPQ----------LASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAV 244

  Fly   399 ATWSLAECARKHIDATPENRRTVLGPLCLTPRYLRMTASEFRRCCERLELLPPTEISLITDALDG 463
            ..|:.|||.|:.:..|..|::.|||......|:..||..||        ...|.:..:::|
Human   245 VRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEF--------AAGPAQSGILSD---- 297

  Fly   464 KKLKNLTDQQAELLEKF------RQPRAEYARMP 491
                      .|::..|      .:||.||...|
Human   298 ----------REVVNLFLHFTVNPKPRVEYIDRP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axed	NP_001356975.1	BTB	<192..258	CDD:197585	10/65 (15%)
axed	NP_001356975.1	BACK	<354..423	CDD:355779	21/68 (31%)
BTBD1	NP_079514.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		11/46 (24%)
		BTB	62..175	CDD:306997	30/159 (19%)
		BACK	187..286	CDD:197943	32/117 (27%)
		PHR	334..480	CDD:311801
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810