DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axed and BTBD3

DIOPT Version :9

Sequence 1:	NP_001356975.1	Gene:	axed / 38741	FlyBaseID:	FBgn0035708	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001381934.1	Gene:	BTBD3 / 22903	HGNCID:	15854	Length:	522	Species:	Homo sapiens

Alignment Length:	408	Identity:	84/408 - (20%)
Similarity:	134/408 - (32%)	Gaps:	153/408 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KEKRITK--FPLVGALVHKALRRREEAEDEKVQITGPEDNQHQQNNNNNDWEPNRMVLPFGLGPD 112
            |:|::..  ||           |::.|......:    ...||||.:||:
Human    58 KKKKMAADIFP-----------RKKPANSSSTSV----QQYHQQNLSNNN--------------- 92

  Fly   113 GHHVDAIQSAPAPSAPPAHMMPPAYARGQTNIYTGVPIIVNPYIDFIVVNGDDRYMIRCERKSVL 177
                    ..|||                                    |....|....||.:::
Human    93 --------LIPAP------------------------------------NWQGLYPTIRERNAMM 113

  Fly   178 ERSVELAKLIH--AGPNSG-RKSDNHFQILNVDKNDFELIVRYMEKHFIPYRDHKHLLKILELSD 239
            ..: :|...:|  .||..| ::...|..:|.|..:.|         |.:.|.:      :.|..|
Human   114 FNN-DLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVF---------HAMFYGE------LAEDKD 162

  Fly   240 RFNVPDL----------IIYCIRELDLRISSATALDIFKALWFYQGIALTNQHQTVITTQETGQQ 294
            ...:||:          .||| .|:||      |.|                  ||:.|
Human   163 EIRIPDVEPAAFLAMLKYIYC-DEIDL------AAD------------------TVLAT------ 196

  Fly   295 LARKKATKAKAAAKQLAAAKASQSTENGAEGDGAQQN---LIPNPNPFTTEDYGVALLHNTLQLI 356
                     ..|||:......:::..|..|...:.:|   |:.....|...|    |.....::|
Human   197 ---------LYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPD----LTQRCWEVI 248

  Fly   357 DMHAELQLSMPEISDLRFEELETLVKRDTLQLRSEVTLFECLATWSLAECARKHIDATPENRRTV 421
            |..|||.|......|:.|:.||::::|:||..: |:.:||....|:..||.|:.:..:.||:|.|
Human   249 DAQAELALKSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEVECQRQDLALSIENKRKV 312

  Fly   422 LGPLCLTPRYLRMTASEF 439
            ||......|...|...:|
Human   313 LGKALYLIRIPTMALDDF 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axed	NP_001356975.1	BTB	<192..258	CDD:197585	17/76 (22%)
axed	NP_001356975.1	BACK	<354..423	CDD:355779	24/68 (35%)
BTBD3	NP_001381934.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45774
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100