Protein Alignment Rexo5 and PAN2

DIOPT Version :10

• Sequence 1: NP_648050.1
• Gene: Rexo5 / 38740
• FlyBaseID: FBgn0286051
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_011421.1
• Gene: PAN2 / 852786
• SGDID: S000003062
• Length: 1115
• Species: Saccharomyces cerevisiae
• Alignment Length: 621
• Identity: 132/621 - (21%)
• Similarity: 226/621 - (36%)
• Gaps: 200/621 - (32%)

  Fly    14 EKKKKKLAALAN----LMELNDRDRLHEAELAKKRDAEVE---VEEKSTAKAEDGDDGFIVVGSK 71
            |:...|:.:.:|    |..|.|:.:|...|..:..:..:|   :.|    ..||.:....:..:.
Yeast   558 ERSHGKICSSSNFQASLKSLTDKRQLENGEPQEHLEEYLESLCIRE----SIEDFNSSESIKRNM 618

  Fly    72 RKPRNRRQNNEL-EADSQTAPGTSDPEEPVNKKIR------------------NYDAGGDSLP-L 116
            .:..||...::| :.::||          ||..|.                  :||.....|| |
Yeast   619 PQKFNRFLLSQLIKEEAQT----------VNHNITLNQCFGLETEIRTECSCDHYDTTVKLLPSL 673

  Fly   117 EIGSLSEDQYNQLSAELRRRKRELENV-PALR--LREMGQRASL-------ETPQDARTPIFLTD 171
            .|..:::....||:     :|...:|: |.:.  ::.:.|:.|:       ||.....|...|..
Yeast   674 SISGINKTVIKQLN-----KKSNGQNILPYIEYAMKNVTQKNSICPTCGKTETITQECTVKNLPS 733

  Fly   172 IQNLLMCALIGQKSPCRPDR-WCSVEKWLSLSHSVVVILEGLSLYHYLSNETQFEATNRIFSTKL 235
            :.:|.:..|..:.|..|..: |.:.|.:.|:..:..|:         .|..::.:.|:.||..:|
Yeast   734 VLSLELSLLDTEFSNIRSSKNWLTSEFYGSIIKNKAVL---------RSTASELKGTSHIFKYEL 789

  Fly   236 EMILPPQEEGQKIIDEIAKIPLTNAQARRL--IDEHGSLES-----------AVELN-------- 279
            .             ..:|||...|.:.|.:  :.::...|:           .||:.
Yeast   790 N-------------GYVAKITDNNNETRLVTYVKKYNPKENCFKWLMFNDYLVVEITEEEALKMT 841

  Fly   280 ---KDPTLFV--------KTIFPIESSKSESDDMHED-------------------DKFPRTKLL 314
               |.|.:.:        |..|.:::.....|.:..|                   |:.|::..|
Yeast   842 YPWKTPEIIIYCDAEELRKPFFSVDTYSINYDILFRDYFANGIRDTARREYKLLTHDEAPKSGTL 906

  Fly   315 LSALQMVDEGYPIPLQGELHTRFQNFKFTKDLYAPVTNRSPMFGVDCEMCHTEAGCNE------- 372
            ::    :|..: :.||.||                           ||:.|  .|...
Yeast   907 VA----IDAEF-VSLQSEL---------------------------CEIDH--QGIRSIIRPKRT 937

  Fly   373 -LTRISIVNENYETVY-----ETLVLPNNRITDYLTQYSGITAEIM--EQVTKRL---DVVQKEV 426
             |.||||:......:|     :..|:..|.|.||||:||||....:  |:.||||   :||.::|
Yeast   938 ALARISIIRGEEGELYGVPFVDDYVVNTNHIEDYLTRYSGILPGDLDPEKSTKRLVRRNVVYRKV 1002

  Fly   427 SELLPPDAILVGQSLNSDLNAMKMMHP--YVIDTSVCFNTSGVRRRKTKLKDLAKTFLQEIIQEN 489
            ..|:....:.||..||:|...:.:..|  .:.||::.|...   :|...|:.||...|...|||.
Yeast  1003 WLLMQLGCVFVGHGLNNDFKHININVPRNQIRDTAIYFLQG---KRYLSLRYLAYVLLGMNIQEG 1064

  Fly   490 IDGHDSIEDSRATLKLVKK-----------KLANSI 514
              .||||||:...|.|.||           |:.||:
Yeast  1065 --NHDSIEDAHTALILYKKYLHLKEKAIFEKVLNSV 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rexo5	NP_648050.1	REX1_like	357..507	CDD:99848	55/169 (33%)
PAN2	NP_011421.1	WD40	<168..>328	CDD:441893
		UCH_1	505..829	CDD:463872	56/311 (18%)
		PAN2_exo	907..1080	CDD:99846	60/211 (28%)