Protein Alignment Rexo5 and REXO4

DIOPT Version :10

• Sequence 1: NP_648050.1
• Gene: Rexo5 / 38740
• FlyBaseID: FBgn0286051
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_065118.2
• Gene: REXO4 / 57109
• HGNCID: 12820
• Length: 422
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 113/517 - (21%)
• Similarity: 180/517 - (34%)
• Gaps: 192/517 - (37%)

  Fly    68 VGSKRKPRNRRQNNELEADSQTAPGTSDPEEPVNKKIRNYDAGGDSLPLEIGSLSEDQYNQLSAE 132
            :|..:.|.::|.                |..||.|            |..:.:|:..:..:....
Human     1 MGKAKVPASKRA----------------PSSPVAK------------PGPVKTLTRKKNKKKKRF 37

  Fly   133 LRRRKRELENVPALRLREMGQRASLETPQDARTPIFLTDIQNLLMCALIGQKSPCRPD---RWCS 194
            .:.:.||:...||     .|..|.:..|                       |:|  .|   .|.:
Human    38 WKSKAREVSKKPA-----SGPGAVVRPP-----------------------KAP--EDFSQNWKA 72

  Fly   195 VEKWLSLSHS------VVVILEGLSLYHYLSNETQFEATNRIFSTKLEMILPPQEEGQKI----- 248
            :::||....|      :|:...|......:..:.:.|.:             ||.:|:::
Human    73 LQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETS-------------PQVKGEEMPAGKD 124

  Fly   249 -------------IDEIAKIPLTNAQARRLIDEHGSLESAVELNKDPTLFVKTIFP----IESSK 296
                         :|..|.:|.|.|..    .||....:....|.|       |.|    ||..|
Human   125 QEASRGSVPSGSKMDRRAPVPRTKASG----TEHNKKGTKERTNGD-------IVPERGDIEHKK 178

  Fly   297 SES----------DDMHEDDKFP----------RTKLLLSALQMVDEGYPIPLQGELHTRFQNF- 340
            .::          :|:..||..|          ..|:....|...:....:.|..|     |.|
Human   179 RKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKE-----QAFG 238

  Fly   341 KFTKDLYAPVTNRSPMFGVDCEMCHTEAGCNE--LTRISIVNENYETVYETLVLPNNRITDYLTQ 403
            ..|:.|           .:||||........|  ..|:||||:..:.||:..|.|...:|||.|.
Human   239 GLTRAL-----------ALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTA 292

  Fly   404 YSGITAEIMEQVTKRLDVVQKEVSELLPPDAILVGQSLNSDLNAMKMMHPYVIDTSVCFNTSGVR 468
            .|||..|.::| .:.|:||||||:|:| ...||||.:|::||..:.:.||
Human   293 VSGIRPENLKQ-GEELEVVQKEVAEML-KGRILVGHALHNDLKVLFLDHP--------------- 340

  Fly   469 RRKTKLKDLA--KTFLQEI---------IQENIDG-------HDSIEDSRATLKL---VKKK 509
              |.|::|..  |.|..::         :.|.|.|       |.||:|::|.::|   |||:
Human   341 --KKKIRDTQKYKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKE 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rexo5	NP_648050.1	REX1_like	357..507	CDD:99848	55/172 (32%)
REXO4	NP_065118.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..194		43/274 (16%)
		REX4_like	244..394	CDD:99847	55/179 (31%)