DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ndl and Tmprss11b

DIOPT Version :9

Sequence 1:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster
Sequence 2:	NP_001004020.1	Gene:	Tmprss11b / 365265	RGDID:	1303278	Length:	420	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	80/272 - (29%)
Similarity:	133/272 - (48%)	Gaps:	44/272 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1135 DSKEIVGD------------GRIVGGSYTSALQWPFVVAIYRNGKFHCGGTIYSDRWIISAAHCV 1187
            |:::|:.:            .||.|||.....:||:..::..|||.|||.::..:|::::||||.
  Rat   167 DAEKIINNRCGRRPRMSATYDRITGGSTAQKGEWPWQASLRVNGKHHCGASLIGERFLLTAAHCF 231

  Fly  1188 INYGKYFYEVRAGLLRRSSYSPATQIQP------VSHVVVHQAYERRSMRNDLSLLRLLNPLQFN 1246
            :         |....:..:.|..|::.|      |..|::|:.|.:....:|:::::|...:.|.
  Rat   232 L---------RTNNPKNLTVSFGTRVTPAYMQHYVEEVIIHEDYVKGQHHDDVAIIKLTEKVSFR 287

  Fly  1247 RWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPI--RKKCTDPE 1309
            ..|..:|||:..:       ::.|.|..:  |.|||::...|.|...:::..:.|  ...|...|
  Rat   288 NDVHRVCLPEATQ-------VFPPGEGVV--VTGWGSLSYNGKSPLLLQKASIKIIDTNACNSEE 343

  Fly  1310 DQASE----DICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTR 1370
            .....    .:|||..:|..|||||||||||.  ..::.|.:||.|:||.|:.|.|..:.|||.|
  Rat   344 AYGGRIMDTMLCAGYMEGYVDACQGDSGGPLV--HPNSRDIWYLVGIVSWGHECGRVNKPGVYMR 406

  Fly  1371 VTLYLDWLEMAT 1382
            ||.|.||:...|
  Rat   407 VTSYRDWIASKT 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ndl	NP_523947.2	LDLa	891..927	CDD:238060
		Tryp_SPc	1144..1377	CDD:214473	75/244 (31%)
		Tryp_SPc	1145..1379	CDD:238113	76/245 (31%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Tmprss11b	NP_001004020.1	SEA	50..144	CDD:279699
		Tryp_SPc	188..414	CDD:214473	76/245 (31%)
		Tryp_SPc	189..417	CDD:238113	76/247 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010