Protein Alignment ndl and Corin

DIOPT Version :10

• Sequence 1: NP_523947.2
• Gene: ndl / 38738
• FlyBaseID: FBgn0002926
• Length: 2616
• Species: Drosophila melanogaster
• Sequence 2: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 1370
• Identity: 274/1370 - (20%)
• Similarity: 439/1370 - (32%)
• Gaps: 496/1370 - (36%)

  Fly   327 FDKPQEILRTTE------GPGQ---------RIIRNVTTTSASSEPIVDTENTNSDHVPTTENGL 376
            :.:|:.:  |.|      |.||         .::.::.|..||.  ..|.:..:.|...:.||.:
  Fly   196 YPQPENV--TAEAVVRGSGDGQGGGGAGLQSALLVDIATRPASG--YADADGISDDDRMSLENSV 256

  Fly   377 VFNITTDGPVETTKSTAQRKLSFDWILDGEENVEPEVKSTNTTTTTAATTTTGATSE-------- 433
            .....|..||:.....|.|......:....:      :|:::|..:|..::.|..||
  Fly   257 FDESLTSTPVKVAGYLAGRYAGLSHMAKRAQ------RSSSSTVDSAYGSSLGGHSERFASSSTS 315

  Fly   434 --------TIIVTTELPKITFDWIIDGREVVEPQETTTEVTGTTERLRKMPFDWIIDGEEVVEPQ 490
                    ::...:.|.:......||.....:|::...|.....:.:.|:              .
  Fly   316 VDFRSRFSSVDTQSSLDEKPLSSSIDSPLARDPRDAYRERAVLNDAMHKL--------------N 366

  Fly   491 ENVTTTTIATTVAVSTTEINERIHNSTAYPT-----KPKPVKFDWIIDGGESSGEVSTSSTSQPK 550
            .|.|:..:|...|.:....:....:.:..|.     :|.|||..  .:...|.||..:.|:.:|.
  Fly   367 NNNTSLGLALYSASNNNNGSSVASDGSQLPVVPARKQPPPVKGS--SNSSNSIGETQSQSSKEPS 429

  Fly   551 LTTREAISNPESPRSSHPLDNPTSIENMLESFEQHEEQKPILRVLNANESSSETVTDGYERQLWL 615
            ..:..|.::                                    :|..:.|.|::.|
  Fly   430 SVSASASTS------------------------------------SAASAGSSTISSG------- 451

  Fly   616 KKFEDQARPNQNELIDTFGTALDAKALDKMGPKINPLNGHTWNAADAQILSLCERVA-------L 673
             .....:.|....:..|     || ...:.||...||.       .|.:....|..:       |
  Fly   452 -TMSSMSGPCPAVVPPT-----DA-ITKRPGPPEPPLR-------QANVFDPVETGSRGHPPPPL 502

  Fly   674 RMRNKVATMSDGETKEKGETFTASPSVQFTSRAPGGFPVSGETMKASAQFMFNPNFGMPSIPVCF 738
            .:|||:     |..|....|:......|.::.:...:.:|.           :|.:
  Fly   503 TVRNKL-----GRNKPPPITYPRMQQRQDSTLSSDSYSISS-----------SPGY--------- 542

  Fly   739 YMTPANFRMPMWSNTPTFMGMQGAHFGGSSN-PGAGIFFVP-QQFGPSGNFFGGS-GGSGAGGQG 800
                 |.::   ...|.....||   |..|| ||:.....| ....|: .|.||: ||:|:|.||
  Fly   543 -----NSKL---MEAPLLGSQQG---GRKSNAPGSAQRQTPLMDLAPT-RFLGGAGGGTGSGKQG 595

  Fly   801 -------------------ANIFSKNASP-----------------QKPTNGQQQVYC------- 822
                               ::.||:.:||                 ::..:....:.|
  Fly   596 PAMPPPRSKINFRQDSTISSDSFSQTSSPGYNPKLMEAPLLPSLSAKRLCSAPAPIVCRQGVQHE 660

  Fly   823 -----------SYMQNQSGQGA----------GQSQTSSQQQQ---------------------- 844
                       |.:...:||.:          |...|.|.|.|
  Fly   661 PIEELEPPQTISPLHKAAGQPSSLQTIVRFQNGAPHTMSLQHQIINRRKSSNPYITNGRLKFRLF 725

  Fly   845 -------------GGQSAFSNANFKMRHANQT--NTAN------------------------QQG 870
                         ||.:|:.||...::..|:|  ||.:                        |..
  Fly   726 QILINAFALLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGP 790

  Fly   871 QI-----IYASYAG--------------------------------------------------- 879
            ||     ::.:|.|
  Fly   791 QIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTL 855

  Fly   880 ------------------LPQ-------------------QPIQERSRC---PEPDQFSCFGQQE 904
                              ||:                   ..::|..|.   |:.|.|.| .|..
  Fly   856 CTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQC-DQNR 919

  Fly   905 CIPAARWCDNVVDCSDGSDESACTCADRVDEERLCDGYEDCPMGEDELGCFGCESLAYSCYENPQ 969
            |:|....||..:||.|.:||:.|               |.|  |.||:.|..
  Fly   920 CLPQEYVCDGHLDCMDQADEAKC---------------ERC--GPDEIYCGD------------- 954

  Fly   970 DFAKRNRSTISMCYSRLERCDGFMNCLNGRDEEQCSMLVTDVADHMSHGASASEGYLYHNYRGDW 1034
                      |.|......|||.::|..|:||..|..|.....|   .|....|  :|...:..|
  Fly   955 ----------SQCIGTKHICDGIIDCPYGQDERNCLRLSERNGD---VGTGVLE--VYRIGQRQW 1004

  Fly  1035 HPVCNNGEKWAALACQMDENSRMDHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQACHGRNSHDS 1099
            .|.|  .:.|..........|.:.:||....|..|.....|.: .:::......:....|.|  :
  Fly  1005 MPAC--VKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLL-ATVNVSTDIWKMYAKRKS--T 1064

  Fly  1100 LVDHVAYVK-----------CPPMQCGLPSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSA 1153
            |:...|..|           |...:||            ||:|.......     ||:||:..|.
  Fly  1065 LMQEFANCKKTEDYPMADLTCSNYECG------------RVKRGRHKPSR-----RIIGGTQASP 1112

  Fly  1154 LQWPFVVAIYRNGK--FHCGGTIYSDRWIISAAHCVINYGKYFYE---VRAGLLRRSSYSPATQI 1213
            ..|||:.||....:  |:|.|.:.||:|:::|:|||.||.....|   ::.|:.||:|::.:.|.
  Fly  1113 GNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQK 1177

  Fly  1214 QPVSHVVVHQAYERR-SMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEH--TL 1275
            ..|..|:.|..|... :..||::|.:|...:.|:..:.|:|||......:          |  ||
  Fly  1178 VKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNL----------HPGTL 1232

  Fly  1276 CTVVGWGAIREKGPSSD---PMRQVIVPI--RKKCTDPEDQ--ASED-ICAGDPDGGRDACQGDS 1332
            |||:|||...:|.|.|.   .:.:|.|||  |.:|.:..|.  .||. :|||..|||:|||||||
  Fly  1233 CTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDS 1297

  Fly  1333 GGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDWLEMATTPRLLP----KLQPL 1393
            ||||.|......:.:::.|:||.|..||.|:..|||..|..|:.|::........|    ::...
  Fly  1298 GGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIKEDRVNKY 1362

  Fly  1394 QLCPG 1398
            .|.||
  Fly  1363 DLHPG 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ndl	NP_523947.2	LDLa	891..927	CDD:238060	14/38 (37%)
		Tryp_SPc	1145..1379	CDD:238113	92/249 (37%)
		LDLa	1399..1430	CDD:238060	274/1370 (20%)
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	7/115 (6%)
		LDLa	911..942	CDD:238060	13/31 (42%)
		LDLa	945..979	CDD:238060	14/58 (24%)
		SR	980..>1034	CDD:214555	12/60 (20%)
		Tryp_SPc	1104..1346	CDD:238113	92/251 (37%)