DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ndl and Tmprss11g

DIOPT Version :9

Sequence 1:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster
Sequence 2:	NP_796136.2	Gene:	Tmprss11g / 320454	MGIID:	2444058	Length:	417	Species:	Mus musculus

Alignment Length:	395	Identity:	101/395 - (25%)
Similarity:	174/395 - (44%)	Gaps:	65/395 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1028 HNYRGD-WHPVCNNGEKWAALACQMDENSRMDHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQAC 1091
            |.|:.. |.|..|.....:....:.....:...|..::|.||..:|...:::         :|..
Mouse    48 HYYQASFWIPSINYSSDLSKEQSKFRTGLKQKISNEIDVIFQRSSLKHHYVK---------SQVV 103

  Fly  1092 HGRNSHDSL-VDHVAYVKCPPMQCG-------------LPSKSSMLEHSKRV----RRAVSDSKE 1138
            :.|.|:|.: .|.:...:.|....|             |.|..|:|:....:    ....:.::.
Mouse   104 NFRPSNDGVKADVLIKFQIPRKNAGTLKRQADNILQEKLQSSQSILKRDASLPYLREMNAAQAEH 168

  Fly  1139 IV----GDG-------RIVGGSYTSALQWPFVVAIYRNGKFHCGGTIYSDRWIISAAHCVINY-G 1191
            |:    |.|       ||..|.......||:..::...|...||.::...:|::::|||..|| .
Mouse   169 ILNSDCGSGMEYPPIARIADGKPADKASWPWQSSLQVEGIHLCGASLIGSQWLVTSAHCFDNYKN 233

  Fly  1192 KYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPD 1256
            ...:.|..|   |:..||.| .:.|..::||:.|......:|:::::|.:|:.|:..:..:||||
Mouse   234 PKLWTVSFG---RTLSSPLT-TRKVESIIVHENYASHKHDDDIAVVKLSSPVLFSENLHRVCLPD 294

  Fly  1257 KGRTTVGDDWIWGPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPIRKKCTDPEDQ--------AS 1313
            .....:....::         |.||||::..||..:.:::|.:.|..  .|..:|        :|
Mouse   295 ATFQVLPKSKVF---------VTGWGALKANGPFPNSLQEVEIEIIS--NDVCNQVNVYGGAISS 348

  Fly  1314 EDICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDWL 1378
            ..||||...|..|||:|||||||...  .|.:::||.|:||.|..|.:..:.|:|||||.|.||:
Mouse   349 GMICAGFLTGKLDACEGDSGGPLVIS--DNRNKWYLLGIVSWGIDCGKENKPGIYTRVTHYRDWI 411

  Fly  1379 EMATT 1383
            :..|:
Mouse   412 KSKTS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ndl	NP_523947.2	LDLa	891..927	CDD:238060
		Tryp_SPc	1144..1377	CDD:214473	74/241 (31%)
		Tryp_SPc	1145..1379	CDD:238113	75/242 (31%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Tmprss11g	NP_796136.2	SEA	48..142	CDD:279699	17/102 (17%)
		Tryp_SPc	185..411	CDD:214473	75/242 (31%)
		Tryp_SPc	186..414	CDD:238113	75/244 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010