DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ndl and Tmprss11g

DIOPT Version :9

Sequence 1:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster
Sequence 2:	NP_001008554.1	Gene:	Tmprss11g / 289546	RGDID:	1306446	Length:	417	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	88/340 - (25%)
Similarity:	159/340 - (46%)	Gaps:	66/340 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1052 DENSRMDHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQACHGRNSHDSLVDHVAYVKCPPMQCGL 1116
            :.:|.::.....:.||....:..|::..     ::.|||.|..||:                |||
  Rat   133 EADSILNKKLQSSQSFLKRDISLPYLRE-----MNAAQAEHILNSN----------------CGL 176

  Fly  1117 PSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSALQWPFVVAIYRNGKFHCGGTIYSDRWII 1181
            .     :|:.:..|         :.||:..|.:     .||:..::...|...||.::...:|::
  Rat   177 G-----MEYPRIAR---------IADGKPAGSN-----SWPWQSSLQVEGIHLCGASLIGSQWLV 222

  Fly  1182 SAAHCVINY-GKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQF 1245
            ::|||..|| ....:.|..|   |:..:|.| .:.|..:::|:.|......:|:::::|.:|:.|
  Rat   223 TSAHCFDNYKNPKLWTVSFG---RTLGNPLT-TRKVESIIIHENYAAHKHDDDIAVVKLSSPVLF 283

  Fly  1246 NRWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPIRKKCTDPED 1310
            :..::.:|||:.....:....::         |.||||::..||..:.:::|.:.|..  .|..:
  Rat   284 SENLRTVCLPEATFQVLPKSKVF---------VTGWGALKANGPFPNSLQEVEIEIIS--NDVCN 337

  Fly  1311 Q--------ASEDICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGV 1367
            |        :|..||||...|..|||:|||||||...  .|.:::||.|:||.|..|.:..:.|:
  Rat   338 QVNVYGGAISSGMICAGFLTGKLDACEGDSGGPLVIS--DNRNKWYLLGIVSWGIDCGKENKPGI 400

  Fly  1368 YTRVTLYLDWLEMAT 1382
            |||||.|.:|::..|
  Rat   401 YTRVTHYRNWIKSKT 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ndl	NP_523947.2	LDLa	891..927	CDD:238060
		Tryp_SPc	1144..1377	CDD:214473	69/241 (29%)
		Tryp_SPc	1145..1379	CDD:238113	70/242 (29%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Tmprss11g	NP_001008554.1	SEA	48..142	CDD:279699	1/8 (13%)
		Tryp_SPc	185..411	CDD:214473	72/256 (28%)
		Tryp_SPc	186..414	CDD:238113	72/249 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010