DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ndl and si:dkey-32n7.7

DIOPT Version :9

Sequence 1:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster
Sequence 2:	XP_021335883.1	Gene:	si:dkey-32n7.7 / 108191692	ZFINID:	ZDB-GENE-121214-179	Length:	609	Species:	Danio rerio

Alignment Length:	668	Identity:	142/668 - (21%)
Similarity:	235/668 - (35%)	Gaps:	230/668 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   802 NIFSKNASPQKP------TNGQ--QQVYCSYMQNQSGQGAGQSQTSSQQQQGGQSAFSNANFKMR 858
            |..||:::...|      .:|:  ::::..|       |..:.:.:.|...|...........:.
Zfish    43 NKLSKSSNVNVPGRWVFRVDGRSNEEIFYPY-------GDAEDEINPQSDDGSSPPIPLLQSFVY 100

  Fly   859 HANQTNT--ANQQGQIIYASYAGLPQQPIQERSRCPEPDQFSCFGQQECIPAARWCDNVVDCSDG 921
            ..|..:|  .|..|.:.:       .:|:.:.:    ||.|..:..::.| |..|.|
Zfish   101 FGNTYDTIFVNNNGDLTF-------DKPLHQYN----PDNFPAYSTRDII-APLWTD-------- 145

  Fly   922 SDESACTCADRVDEERLCDGYEDCPMGEDELGCFGCESLAYSCYENPQDFAKRNRSTISMCYSRL 986
                            :.:|.|.              :::|....| .|...|....|:..:..|
Zfish   146 ----------------INNGMEG--------------TISYRQVTN-GDILNRASKDINRYFPNL 179

  Fly   987 ERCDGFMNCLN-------GRDEEQCS---MLVTDVA--------DHMSHGASASEGY-------L 1026
            .....::....       |..|.:.:   :||:|..        |::::..||..||       .
Zfish   180 NFSASWVFIATWDKVPYYGYRESESTFQVVLVSDKKRSFTLMHYDYITYTQSAESGYDTNGSTVF 244

  Fly  1027 YH---------------NYRGDWHPVCNNGEKWAALACQMDENSRMDHSASLNVSFQTLTLPGPF 1076
            |.               |.:|.|             ..::|.:|.:..|. :|.:.|.|..|...
Zfish   245 YSIPVSDVTNLPYTSNVNVKGRW-------------VFRVDNSSEVKGSC-INTNSQALDSPSAA 295

  Fly  1077 IEPSLHAGVHFAQACHGRNSHDSLVDHVAYVKCPPMQCG-LPSKSSMLEHSKRVRRAVSDSKEIV 1140
            :                                    || :|..||
Zfish   296 V------------------------------------CGIIPVNSS------------------- 305

  Fly  1141 GDGRIVGGSYTSALQWPFVVAIYRNGKFHCGGTIYSDRWIISAAHCVINYGKYFY-EVRAGLLRR 1204
              ...|||..:||:.||:..::|......|||::.:..|::|||||.......|| .|..|...:
Zfish   306 --NGTVGGQNSSAVHWPWQASLYWYSGQTCGGSLINKEWVLSAAHCFNGQRNGFYLTVILGPKTQ 368

  Fly  1205 SSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTTVGDDWIWG 1269
            :.|.|:...:.|..|:.|..|...:..||::|:||..|:.|...::|:||..:|.....|...|
Zfish   369 NKYDPSRISRSVKAVIKHPYYNPNTNDNDIALVRLSFPITFTDSIRPVCLAAEGSVFNSDTESW- 432

  Fly  1270 PVEHTLCTVVGWGAIREKGPSSDP--MRQVIVPI--RKKC---------TDPEDQASEDICAGDP 1321
                    :..|..|.:..|...|  .::|.||:  .::|         ||      ..||||..
Zfish   433 --------ITTWRNISDGVPLPSPKIFQEVEVPVIGNRQCNCLYGVGSITD------NMICAGLL 483

  Fly  1322 DGGRDACQGDSGGPLFCRSVSNPDEFYL-AGVVSHGNGCARPQEFGVYTRVTLYLDWLEMATTPR 1385
            ..|:|.||||||||:    |||....:: :|:||.|:|||:.:..||||||:.|.:|:...|
Zfish   484 KEGKDLCQGDSGGPM----VSNQSSVWVQSGIVSFGSGCAQSEFPGVYTRVSRYQEWITYFT--- 541

  Fly  1386 LLPKLQPLQLC---PGFI 1400
                      |   |||:
Zfish   542 ----------CSDPPGFV 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ndl	NP_523947.2	LDLa	891..927	CDD:238060	7/35 (20%)
		Tryp_SPc	1144..1377	CDD:214473	81/247 (33%)
		Tryp_SPc	1145..1379	CDD:238113	82/248 (33%)
		LDLa	1399..1430	CDD:238060	1/2 (50%)
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
si:dkey-32n7.7	XP_021335883.1	NIDO	4..63	CDD:310601	4/19 (21%)
		NIDO	141..272	CDD:322035	24/182 (13%)
		Tryp_SPc	309..537	CDD:238113	81/246 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010