DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ndl and LOC100495541

DIOPT Version :9

Sequence 1:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster
Sequence 2:	XP_031749237.1	Gene:	LOC100495541 / 100495541	-ID:	-	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	705	Identity:	170/705 - (24%)
Similarity:	256/705 - (36%)	Gaps:	210/705 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 PMQCGLPSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSALQWPFVVAIYRNGKFHCGGTIY 1175
            |:.||.|    :|.:                  ||||||..:...||:.|::...|...|||::.
Frog    32 PLVCGSP----LLPN------------------RIVGGSAATEGAWPWQVSLRYKGIHICGGSVI 74

  Fly  1176 SDRWIISAAHC-VINYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRL 1239
            ...||::|||| :|:.....:|||.|..:.|..||......|..::|:..::..|...|::|:|.
Frog    75 GTHWILTAAHCFLISQSPSDFEVRLGAYQLSLTSPNEITYKVDRIIVNSQFDSSSHYGDIALIRP 139

  Fly  1240 LNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVVGWG--AIREKGPSSDPMRQVIVPI- 1301
            .:|:.:..::.|:|||....:.         .|...|.|.|||  |.:...|....::||:.|:
Frog   140 TSPITYTPYILPVCLPSTSNSF---------PEGMECWVTGWGTTAFQVNLPYPQTLQQVMTPLI 195

  Fly  1302 -RKKCTD--------PEDQA---SEDICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVS 1354
             |..|..        |...|   |:.||||...|.:|:|||||||||.|:.   ...:|..|.|:
Frog   196 SRTSCDQMYHIGTNVPSSTAIIPSDQICAGYAAGQKDSCQGDSGGPLVCKL---QGIWYQIGFVT 257

  Fly  1355 HGNGCARPQEFGVYTRVTLYLDWL-------------EMATT--PRL---------LPKLQPLQL 1395
            .|:|||.....||||.|..|..||             .:.||  |.|         |.|..||..
Frog   258 WGDGCAIANRPGVYTLVPAYQSWLSSYNATENTVNVDSVPTTAPPTLISNVSSLFSLSKSAPLPG 322

  Fly  1396 CPGFICVWGGKRCIAKRQRCDRNVDCLGGEDEVGCTYNFLPD-MVGGVRQNISTTTES------- 1452
            ....:|:|    .||..:....:.........:.|....:.: :|||     :..|:.
Frog   323 ACSLLCIW----LIAMAKDSSVSPSVSDTTSTLSCGSPLVSNRIVGG-----TDATDGAWPWQVS 378

  Fly  1453 -DYHPVKESEEKSKMREVIPIDDEDLKAEQDEEDLLKSTTSLGQTETTQGPMDLSFAEQITSTTS 1516
             |||                                .|....|....||..|..:...:.:.:.|
Frog   379 LDYH--------------------------------GSHICGGSLIATQWIMTAAHCFEYSKSPS 411

  Fly  1517 D--------DLSITD--ETTST-DFTVSDSATSPST----LLPTTTNPSTW--------LPSTNI 1558
            |        .||:..  |.||| |..:.:|..|.||    .|...|:|.|:        ||||
Frog   412 DYKIRLGAYQLSLISPHEITSTVDSIIVNSPNSSSTNTDIALIRLTSPITYTKYILPICLPST-- 474

  Fly  1559 ETSTFSFTTTESEASTK-QETLPT---TVAQTTTIPTSTEDLKKLTDLVTEFIESTTFETTMEVE 1619
                       |:..|: .|...|   |:|....:|......:.:|.|::....:..:.|
Frog   475 -----------SDGFTEGMECWVTGWGTIASQVNLPYPMTLQQVMTPLISRATCNQMYNT----- 523

  Fly  1620 TTTLSLT--------------------STDAPKLVTTEGV---------KETTTTEDTTTISSIV 1655
            .:.||:.                    .:..|.:...:|:         .|.....:...:.::|
Frog   524 DSLLSVVVPLDQICAGYAAGQKDSCQGDSGGPLVCQLQGIWYQIGIVSWGEGCAVRNRPGVYTLV 588

  Fly  1656 TLTTTPLATISTTIL--TTEKHVAVTTLAPTTTTESAKTTTT----HSSSTHSEK 1704
            .      |..|..|.  .|...|:|.|.....||.:|.||||    .|||:..:|
Frog   589 P------AYYSWVIAEENTNNVVSVGTTNSLPTTTAAGTTTTQGNIRSSSSSLDK 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ndl	NP_523947.2	LDLa	891..927	CDD:238060
		Tryp_SPc	1144..1377	CDD:214473	83/248 (33%)
		Tryp_SPc	1145..1379	CDD:238113	84/262 (32%)
		LDLa	1399..1430	CDD:238060	4/30 (13%)
		Metaviral_G	1448..1600	CDD:118131	37/186 (20%)
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
LOC100495541	XP_031749237.1	Tryp_SPc	44..283	CDD:238113	84/250 (34%)
LOC100495541	XP_031749237.1	Tryp_SPc	362..595	CDD:238113	51/293 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010