DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and NDST3

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	XP_016864328.1	Gene:	NDST3 / 9348	HGNCID:	7682	Length:	899	Species:	Homo sapiens

Alignment Length:	858	Identity:	474/858 - (55%)
Similarity:	608/858 - (70%)	Gaps:	39/858 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 RRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRD--THPAPIINCRMINSGGKHIRNASPAPDHR 233
            :|.|:.|....||||....:|    :::|..|.:  :..|..::|..:    :|:      |...
Human    12 QRTVILLATFCMVSIIISAYY----LYSGYKQENELSETASEVDCGDL----QHL------PYQL 62

  Fly   234 SEARL-------RIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLPVLTNLDKGR 289
            .|.:.       |.||.||||||:.||.||:||..:|..:|.:|.||:| || .||||.:..||:
Human    63 MEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVLIDKMKGK 127

  Fly   290 YGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNTNLRLRD 354
            |.:|::||:.||:|||.|||.||||||.||.||::||...||:::...||:.||..:..||.::|
Human   128 YILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKD 192

  Fly   355 ASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPADSVGQVQLPLTT 419
            ..:||.|.::|:|::.:...|:|||.||.|||.|||.|:||.:|:..|.|..:.|:.:... ..|
Human   193 CCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKTPENLSPSISKGAF-YAT 256

  Fly   420 VLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVGEKGTRL 484
            ::.|.|..|||||||||::|.||||:|:|:||:|:||..:|:|:|:|.|||||||||||::|||:
Human   257 IIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRM 321

  Fly   485 RPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSHMWKHQQ 549
            ..:||:||:.||..:.|.:..|.||||||||:||.||.||:.|||.||.:|.||.||.|||.|.|
Human   322 NTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQ 386

  Fly   550 PHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVKVTSTEE 614
            |||:.|.:.|:.:|.||..||::|.||||.||:::||||||||.|..||.|||||||:|:|||||
Human   387 PHLFHNESSLVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEE 451

  Fly   615 YPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIVYNPINI 679
            ||||:|||.||||||:||||||||||||||||::...||||..:||:||||||||.|:|.|||:|
Human   452 YPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISI 516

  Fly   680 FMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGNPCDDVR 744
            ||||:||||:|||.||||.::..|::.||||:|.:.||||||..||.|.|::.||:|.|||||.|
Human   517 FMTHLSNYGNDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKR 581

  Fly   745 HKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGNNYYRGL 809
            |:.||||.|.||.||||||||||||||||||.||.||.||.||..||:|||||||||.|||:||:
Human   582 HRDIWSKEKTCDRLPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGI 646

  Fly   810 DWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTILISPAKR 874
            ||||||||..|...|.           |:|||||.||..|..|||:.:|:|.|||:||||.|:.|
Human   647 DWYMDFFPVPSNVTTD-----------FLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDR 700

  Fly   875 AYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYYPAQQLH 939
            |||||||||||.|..|..:|||:||:|...||..|:.|:.|||.||.||.|:|.||.|:|..||.
Human   701 AYSWYQHQRSHEDPAALKFSFYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLL 765

  Fly   940 IIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSKGRQYPA 1004
            ||||:|||.:|..||:|:|:||.:.|..:||..|.:|..|||:||.:.|.:.|||||||||:||.
Human   766 IIDGQQLRTDPATVMDEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPP 830

  Fly  1005 M--DERSAKLLQR 1015
            |  |:.|.|||.|
Human   831 MDSDDISVKLLSR 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	259/500 (52%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	156/260 (60%)
NDST3	XP_016864328.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157078
Domainoid	1	1.000	524	1.000	Domainoid score	I295
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I296
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm41928
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	O	PTHR10605
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770