DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and NDST2

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_003626.1	Gene:	NDST2 / 8509	HGNCID:	7681	Length:	883	Species:	Homo sapiens

Alignment Length:	896	Identity:	485/896 - (54%)
Similarity:	634/896 - (70%)	Gaps:	37/896 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 IARRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINCRMINSGGKHIRN 225
            :.|....:.:.|.:|.|:|.::.|:.:..:||.|..    ..::..|.|:.:|   :|||.
Human     7 VVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSP----KAKEPLPLPLGDC---SSGGA---- 60

  Fly   226 ASPAPDH--------RSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLP 280
            |.|.|..        |.....|.:|.||||||:.||.||::|..:|..:|.:|..|:| |: .:|
Human    61 AGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMP 125

  Fly   281 VLTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLF 345
            .||:...|||.::::|||.||:|:|.|:|||||:||.||.|||:||....|.:|:.|||:.||||
Human   126 TLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLF 190

  Fly   346 VNTNLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQE--YPAD 408
            :::||.|||..:||.:.:|.|||......|.||||||.:||.||||||||..|.....|  .|..
Human   191 LHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGP 255

  Fly   409 SVGQVQLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDID 473
            .:.:.:||  ||:||.|..|||||||||..|.||||:|:|:||::||:..:|.|:|:|.||||||
Human   256 VLRRARLP--TVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDID 318

  Fly   474 DIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEF 538
            |||||::|||::..||.||:.||..:..:||.|.||||||||:||.||.||:.|||.||::.:||
Human   319 DIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEF 383

  Fly   539 NWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKK 603
            .||.|||.|.||||:.|.::|..:|.||..||::|.||||.||:::||||||||.|..||.|||.
Human   384 WWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKS 448

  Fly   604 VWNVKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGEL 668
            ||.::||||||||||||||.||||||..|||||||||||||||::.:.||||..:||.||:||||
Human   449 VWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGEL 513

  Fly   669 FQTIVYNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVD 733
            |.|::.|||:|||||:||||:|||.||||:|:::||||||.|:|.:.|||.||:.||.|.|:|..
Human   514 FLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERS 578

  Fly   734 PVWGNPCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQ 798
            |:|.|||||.|||.||||.|.||.|||||::|||||||||::.|||:|.::.|:..||.||||:|
Human   579 PLWQNPCDDKRHKDIWSKEKTCDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQ 643

  Fly   799 FFNGNNYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAK 863
            |||..||::|:||||||||..|..:|.           |:|||||||||.|.||:|..||||.||
Human   644 FFNSPNYHKGIDWYMDFFPVPSNASTD-----------FLFEKSATYFDSEVVPRRGAALLPRAK 697

  Fly   864 IVTILISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEH 928
            |:|:|.:||.||||||||||:|||.:|.||:|||||:||...|.||:.|:||||.||.|:.||:.
Human   698 IITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQR 762

  Fly   929 WLAYYPAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKC 993
            ||.|||:.||.|:||::||.||...|..:|:||.|.|.|:|:..||:|..|||:||.:...:.:|
Human   763 WLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRC 827

  Fly   994 LGKSKGRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            ||:||||:||.||..|...|..::.|||..|.|||.:|| :|:|.||:::|
Human   828 LGRSKGRRYPDMDTESRLFLTDFFRNHNLELSKLLSRLG-QPVPSWLREEL 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	263/501 (52%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	146/258 (57%)
NDST2	NP_003626.1	HSNSD	25..514	CDD:314871	263/501 (52%)
		Heparan sulfate N-deacetylase 2	41..597		312/568 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..81		10/38 (26%)
		Heparan sulfate N-sulfotransferase 2	598..883		163/292 (56%)
		Sulfotransfer_1	603..852	CDD:307022	146/259 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	524	1.000	Domainoid score	I295
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20803
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I296
Isobase	1	0.950	-	0	Normalized mean entropy	S3088
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm41928
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	O	PTHR10605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820