DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and ndst2b

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	XP_005156429.1	Gene:	ndst2b / 798226	ZFINID:	ZDB-GENE-100430-2	Length:	893	Species:	Danio rerio

Alignment Length:	890	Identity:	472/890 - (53%)
Similarity:	623/890 - (70%)	Gaps:	33/890 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 VRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINC--RMINSGGKHIRNASPAPDH 232
            :.|.:|||:...::|:.|..::|..|   ..|:....|.|:.:|  ..:..||:  |.....|..
Zfish    16 LHRLILALILFCLLSMAYLAYHVSAG---HKIKEAPLPLPLGDCVASSVIGGGQ--RTPLFLPSQ 75

  Fly   233 RSEAR--------LRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLPVLTNLDK 287
            .|:.|        .|.:|.||:|||:.||.||::|..:|..:|..|:.|:| || .:|.|....:
Zfish    76 ISQRRHSAKTVDTSRTEPVVLLFVESIYSQLGQEIVAILESSRFHYRTEIAPGKGDMPPLAWRGR 140

  Fly   288 GRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNTNLRL 352
            |||.:|::|||.||:|:|.|||:||||||::|.|||:||...:|.:...||||.||||:.:||.|
Zfish   141 GRYSLIIYENLLKYVNLDSWNRQLLDKYCQDYGVGIIGFYRANENSPSSAQLRGFPLFLRSNLPL 205

  Fly   353 RDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQ---RNTQEYPADSVGQVQ 414
            .|..::|.:.:|.:|:..|...|.||.|:|..|..||||||||..|.   ....:.|..|..|..
Zfish   206 WDYRVSPAAPLLYITKPNELEPGPLPADNWTTFLSNHSTYEPVLLASPKPAEANQLPTHSHQQRA 270

  Fly   415 LPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVGE 479
            | |.||:||.|..||||||.||.||.||||:|:|:||:.||:..:|||:|:|.:|||:||||||:
Zfish   271 L-LATVVQDLGLHDGIQRVFFGGSLSFWLHKLLFVDAVGYLTGRRLSLSLDRFLLVDVDDIFVGK 334

  Fly   480 KGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSHM 544
            :|||::..||.||:.||..:.::||.|.||||||||::|.||.||:.|||.||::.|||.||.||
Zfish   335 EGTRMKVSDVEALLHTQNKLRSLVPNFTFNLGFSGKFFHTGTDEEDEGDDTLLRHRQEFWWFPHM 399

  Fly   545 WKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVKV 609
            |.|.||||:.|:::|..:|.||..||.:|.||||.||:::||||||||.|..||.|||.||.:||
Zfish   400 WSHMQPHLFHNVSVLAEQMRLNRQFAQEHGIPTDMGYAVAPHHSGVYPVHSQLYEAWKSVWGIKV 464

  Fly   610 TSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIVY 674
            |||||||||||||.||||||..|.|||||||||||||::...||||..:||:||:|||||.|::.
Zfish   465 TSTEEYPHLRPARYRRGFIHNGIQVLPRQTCGLFTHTIFYKDYPGGPQELDKSIRGGELFLTVLL 529

  Fly   675 NPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGNP 739
            ||::|||||:||||:|||.||||:|:::|:||||:|:|.:.|||:||..||::.|:|.||:|.||
Zfish   530 NPVSIFMTHLSNYGNDRLGLYTFESLVRFVQCWTHLRLQTLPPVRLAHKYFQIFPDERDPLWQNP 594

  Fly   740 CDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGNN 804
            |.|.|||.||||.|.||.|||||||||||||||||::|||:|.:|:|:..||.||||||||:|.|
Zfish   595 CHDKRHKDIWSKEKTCDRLPKFLVIGPQKTGTTALHSFLSLHPAISSSYPSPITFEEVQFFSGPN 659

  Fly   805 YYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTILI 869
            |.||:||||||||..|..:|.           |:|||||.|||.|..|||:.||||.|||::|||
Zfish   660 YQRGIDWYMDFFPVPSNVSTD-----------FLFEKSANYFDTETAPKRAAALLPRAKIISILI 713

  Fly   870 SPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYYP 934
            :||.||||||||||:|.|.:|.|::|.:|::|:.|:|.:|..|..|||.||.|:.|||.||.:|.
Zfish   714 NPADRAYSWYQHQRAHQDPVALNHTFDEVVSAAPSSPASLLSLHRRCLQPGAYSSHLERWLHHYQ 778

  Fly   935 AQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSKG 999
            ..||.|:||.|||..|..||:.:|:||.:.|..:|:..|.:|..|||:||.:...|::|||||||
Zfish   779 PSQLLIVDGVQLRSGPAQVMDAIQKFLGVTPYFNYTQALMFDESKGFWCQKLEAGRSRCLGKSKG 843

  Fly  1000 RQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            |:||.|...|...|..||...|..|:::||:|| :|:|.||:|:|
Zfish   844 RKYPDMSLESRAFLSEYYREQNVELLRMLKRLG-QPLPVWLRDEL 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	256/504 (51%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	143/258 (55%)
ndst2b	XP_005156429.1	HSNSD	25..524	CDD:314871	256/504 (51%)
ndst2b	XP_005156429.1	Sulfotransfer_1	613..864	CDD:307022	145/261 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	522	1.000	Domainoid score	I283
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	975	1.000	Inparanoid score	I298
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm24673
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	O	PTHR10605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010