DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and ndst2a

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	XP_021328383.1	Gene:	ndst2a / 793524	ZFINID:	ZDB-GENE-060810-182	Length:	888	Species:	Danio rerio

Alignment Length:	889	Identity:	477/889 - (53%)
Similarity:	630/889 - (70%)	Gaps:	27/889 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 INVRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINCRMI---NSGGKHIRNASPA 229
            :.:.|.:|||:...::|:.:..:||.    |....::..|.|..:|..:   .:||:......|.
Zfish    13 LELHRLILALIIFCLLSMAFLAYYVS----NSPKIKEAPPLPFSDCGGVVADAAGGQRTPLFLPP 73

  Fly   230 PDHRSEA-----RLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVAGK--SLPVLTNLDK 287
            ...|...     ..|.:|.||||||:.||.||::|..:|..:|.:|..|:|..  .:|.|...|.
Zfish    74 FSGRQRTVKVVDNSRTEPVVLVFVESIYSQLGQEIVAILESSRFRYHTEIAPSKGDMPTLMERDI 138

  Fly   288 GRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNTNLRL 352
            |||.::::||:.||:|:|.|||:||||||.|:.|||:||...:|.:|:.|||:.||||:::||.|
Zfish   139 GRYALVIYENILKYVNLDAWNRDLLDKYCSEFGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGL 203

  Fly   353 RDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPADSVGQVQLPL 417
            ||..:||.:.:|.:|:..|...|.||||||.|||.||||||||..|...:.|..| .:|..:...
Zfish   204 RDYHINPAAPLLYITKPNEVEQGLLPGDDWTVFQSNHSTYEPVLLAVTKSSEALA-HLGPHRALH 267

  Fly   418 TTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVGEKGT 482
            .||:||.|..|||||||||::|.||||:|:|:||::||:..:|.|:|||.:|||:||||||::||
Zfish   268 ATVVQDLGLHDGIQRVLFGNNLSFWLHKLIFVDAIAYLTGKRLCLSLERYMLVDVDDIFVGKEGT 332

  Fly   483 RLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSHMWKH 547
            |::..||:||:.||..:..:||.|.||||||||:||.||.||:.|||.|||:..||.||.|||.|
Zfish   333 RMKVTDVKALLNTQNKLRTLVPDFTFNLGFSGKFYHAGTEEEDEGDDMLLQHRHEFWWFPHMWSH 397

  Fly   548 QQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVKVTST 612
            .||||:.|:::|..:|.||..||.:|.||||.||:::||||||||.|..||.|||.:|.:.||||
Zfish   398 MQPHLFHNVSVLAEQMRLNMQFAQEHGIPTDMGYAVAPHHSGVYPVHSQLYEAWKSIWGITVTST 462

  Fly   613 EEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIVYNPI 677
            ||||||||||.|||||||:|.|||||||||||||::.:.||||..:||:||:|||||.|::.|||
Zfish   463 EEYPHLRPARHRRGFIHRDIKVLPRQTCGLFTHTIFYNEYPGGSRELDKSIRGGELFLTVLLNPI 527

  Fly   678 NIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGNPCDD 742
            :|||||:||||:|||.||||:|::||:||||||:|.:.||:.|||.||::.|||:||:|.|||.|
Zfish   528 SIFMTHLSNYGNDRLGLYTFESLVKFVQCWTNLRLQTLPPMDLAEKYFQIFPEEMDPLWQNPCHD 592

  Fly   743 VRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGNNYYR 807
            .|||.||||.|.||.||||||:||||||||||::||::|.:|.||..||.||||:|||||.||:.
Zfish   593 KRHKDIWSKEKTCDRLPKFLVVGPQKTGTTALHSFLTLHPAITSNFPSPVTFEEIQFFNGPNYHN 657

  Fly   808 GLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTILISPA 872
            |:||||||||..|..:|.           |||||||.|||.|..|.|:.||||.|||:.:||:||
Zfish   658 GIDWYMDFFPFPSNVSTD-----------FMFEKSANYFDSEVAPNRAAALLPRAKIIAVLINPA 711

  Fly   873 KRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYYPAQQ 937
            .||||||||||:|.|..|.|::|::|:||..||.:.|..|:||.|.||.||.||||||.::.|:|
Zfish   712 DRAYSWYQHQRAHQDPAAINHTFHEVVTAGPSASKELLTLQNRSLKPGTYATHLEHWLVHFQARQ 776

  Fly   938 LHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSKGRQY 1002
            |||:||..||.||:.||:.:||||.|.|:.:|:..|.:|..|||:||.:...|.|||||||||:|
Zfish   777 LHIVDGTLLRSNPVLVMDGIQRFLGITPIFNYTQALVFDEGKGFWCQRLEGGRPKCLGKSKGRKY 841

  Fly  1003 PAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDLST 1046
            |.|...:...|..||..||..|::||.:|| :.:|.||:::|.:
Zfish   842 PEMAPETRAFLTEYYREHNLELLRLLNRLG-QALPSWLREELQS 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	255/499 (51%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	146/258 (57%)
ndst2a	XP_021328383.1	HSNSD	24..519	CDD:314871	255/499 (51%)
ndst2a	XP_021328383.1	Sulfotransfer_1	608..859	CDD:307022	148/261 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	522	1.000	Domainoid score	I283
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20803
Inparanoid	1	1.050	975	1.000	Inparanoid score	I298
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm24673
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	O	PTHR10605
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.100