DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and NDST4

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_072091.1	Gene:	NDST4 / 64579	HGNCID:	20779	Length:	872	Species:	Homo sapiens

Alignment Length:	891	Identity:	480/891 - (53%)
Similarity:	627/891 - (70%)	Gaps:	29/891 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 NLIA--RRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGL-IQRDTHPAPIINCRMINSGG 220
            |||.  ||.|    |..::.|....:|||....:::.:|....: :...|..|...:.:::....
Human     2 NLIVKLRRSF----RTLIVLLATFCLVSIVISAYFLYSGYKQEMTLIETTAEAECTDIKILPYRS 62

  Fly   221 KHIRNASPAPDHRSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLPVLT 283
            ..::...|....::      ||.||:|||:.||.||:||..:|..:|.:|.:.:| || .:|.||
Human    63 MELKTVKPIDTSKT------DPTVLLFVESQYSQLGQDIIAILESSRFQYHMVIAPGKGDIPPLT 121

  Fly   284 NLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNT 348
            :..||:|.::::||:.||::||.||||||:|||.||||.|:||...:|.:|...||:.|||.:..
Human   122 DNGKGKYTLVIYENILKYVSMDSWNRELLEKYCVEYSVSIIGFHKANENSLPSTQLKGFPLNLFN 186

  Fly   349 NLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPADSVGQV 413
            ||.|:|..:||.|.:|.:|:|.:...|.|||:||.:||:|||||:||...:..| |....|:...
Human   187 NLALKDCFVNPQSPLLHITKAPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQT-EKSLSSLSSK 250

  Fly   414 QLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVG 478
            .| ..||:||.|..|||||||||::|.||||:|:|:||:|:||..:|:|:|:|.|||||||||||
Human   251 TL-FATVIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVG 314

  Fly   479 EKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSH 543
            ::|||:...||:||:.||..:...|..|.||||||||:||.||.||:.|||.||::|.||.||.|
Human   315 KEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEEDEGDDLLLRSVDEFWWFPH 379

  Fly   544 MWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVK 608
            ||.|.||||:.|.:.|:.:|.||..||::|.||.:.||:::||||||||.|..||.||||||.::
Human   380 MWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINMGYAVAPHHSGVYPVHIQLYAAWKKVWGIQ 444

  Fly   609 VTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIV 673
            ||||||||||:|||.|:||||.:|||||||||||||||::...||||..:||:||:|||||.||:
Human   445 VTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIRGGELFLTIL 509

  Fly   674 YNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGN 738
            .|||:|||||:||||:|||.||||.:::.|:|.||||||.:.||||||..||.|.||:.||:|.|
Human   510 LNPISIFMTHLSNYGNDRLGLYTFVNLVNFVQSWTNLKLQTLPPVQLAHQYFELFPEQKDPLWQN 574

  Fly   739 PCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGN 803
            ||||.|||.|||:.|.||.||||||||||||||||||.||.||.||.||:.||:|||||||||||
Human   575 PCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGN 639

  Fly   804 NYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTIL 868
            ||::|:||||||||:.|  ||:|.         |:|||||.||..|..|:|:.:|:|.|||:|||
Human   640 NYHKGIDWYMDFFPTPS--NTTSD---------FLFEKSANYFHSEEAPRRAASLVPKAKIITIL 693

  Fly   869 ISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYY 933
            |.|:.||||||||||||.|..|..::||:||:....||..||.|:.|||.||.||.|:|.||.|:
Human   694 IDPSDRAYSWYQHQRSHEDPAALRFNFYEVISTGHWAPSDLKTLQRRCLVPGWYAVHIERWLTYF 758

  Fly   934 PAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSK 998
            ...||.||||:|||.:|..||:|:|:||.:.|..:||..|.:|.:|||:||.:...:.|||||||
Human   759 ATSQLLIIDGQQLRSDPATVMDEVQKFLGVTPRYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSK 823

  Fly   999 GRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            ||:||.||..|...|..||.:||..|.|||.:|| :|:|.||:.:|
Human   824 GRKYPPMDPESRTFLSNYYRDHNVELSKLLHRLG-QPLPSWLRQEL 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	247/492 (50%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	151/258 (59%)
NDST4	NP_072091.1	HSNSD	20..505	CDD:288882	247/492 (50%)
		Heparan sulfate N-deacetylase 4	36..588		300/559 (54%)
		Heparan sulfate N-sulfotransferase 4	589..872		169/292 (58%)
		Sulfotransfer_1	594..845	CDD:279075	153/261 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	524	1.000	Domainoid score	I295
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I296
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm41928
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	LDO	PTHR10605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870