DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and Ndst4

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001178778.1	Gene:	Ndst4 / 362035	RGDID:	1306531	Length:	872	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	479/891 - (53%)
Similarity:	626/891 - (70%)	Gaps:	29/891 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 NLIA--RRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGL-IQRDTHPAPIINCRMINSGG 220
            |||.  ||.|    |..::.|....:|||....:::.:|....: :...|..|...:.:.:....
  Rat     2 NLIVKFRRSF----RTLIVLLATFCLVSIVISAYFLYSGYKQEMTLVETTAEAECADIKNLPYRS 62

  Fly   221 KHIRNASPAPDHRSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLPVLT 283
            ..::...|....::      ||.||:|||:.||.||:||..:|..:|.:|::.:| || .:|.||
  Rat    63 IELKTIKPIDTSKT------DPTVLLFVESQYSQLGQDIIAILESSRFQYQMVIAPGKGDIPPLT 121

  Fly   284 NLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNT 348
            :..||:|.:|::||:.||::||.||||||:|||.||||.|:||...:|.:|...||:.|||.:..
  Rat   122 DSGKGKYTLIIYENILKYVSMDSWNRELLEKYCIEYSVSIIGFHKANENSLPTTQLKGFPLNLFN 186

  Fly   349 NLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPADSVGQV 413
            |:.|:|.|:||.|.:|.:|:..:...|.|||:||.:||:|||||:||...:..|::  :.|....
  Rat   187 NVALKDCSVNPQSPLLHITKGPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQTEK--SLSFLSS 249

  Fly   414 QLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVG 478
            |....|::||.|..|||||||||::|.||||:|:|:||:|:||..:|:|:|:|.|||||||||||
  Rat   250 QTLYATIIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVG 314

  Fly   479 EKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSH 543
            ::|||:...||:||:.||..:...|..|.||||||||:||.||.||:.|||.||::|.||.||.|
  Rat   315 KEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEEDAGDDLLLRSVDEFWWFPH 379

  Fly   544 MWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVK 608
            ||.|.||||:.|.:.|:.:|.||..||::|.||.:.||:::||||||||.|..||.||||||.::
  Rat   380 MWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINLGYAVAPHHSGVYPVHIQLYAAWKKVWGIQ 444

  Fly   609 VTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIV 673
            ||||||||||:|||.|:||||.||||||||||||||||::...||||..:||:||:|||||.||:
  Rat   445 VTSTEEYPHLKPARYRKGFIHNNIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIKGGELFLTIL 509

  Fly   674 YNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGN 738
            .|||:|||||:||||:|||.||||.::..|:..||||||.:.||||||..||.|.||:.||:|.|
  Rat   510 LNPISIFMTHLSNYGNDRLGLYTFVNLANFVHSWTNLKLQTLPPVQLAHKYFELFPEQKDPLWQN 574

  Fly   739 PCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGN 803
            ||||.|||.|||:.|.||.||||||||||||||||||.||.||.||.||:.||:|||||||||||
  Rat   575 PCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIVSNLPSPKTFEEVQFFNGN 639

  Fly   804 NYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTIL 868
            ||::|::|||||||:.|  |.:|.         |:|||||.||..|..|||:.:|:|.|||:|||
  Rat   640 NYHKGIEWYMDFFPTPS--NITSD---------FLFEKSANYFHSEEAPKRAASLVPKAKIITIL 693

  Fly   869 ISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYY 933
            |.|:.||||||||||||.|..|..::||:|||....||..||.|:.|||.||.||.|:|.||||:
  Rat   694 IDPSDRAYSWYQHQRSHEDPAALRFNFYEVITTGHWAPPDLKTLQRRCLVPGWYAVHIERWLAYF 758

  Fly   934 PAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSK 998
            ...||.||||:|||.:|..||:|:|:||.:.|..:||..|.:|.:|||:||.:...:.|||||||
  Rat   759 STSQLLIIDGQQLRSDPATVMDEVQKFLGVTPHYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSK 823

  Fly   999 GRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            ||:||.||..|...|..||.:||..|.|||.:|| :|:|.||:.:|
  Rat   824 GRRYPPMDPESRTFLSSYYRDHNVELSKLLHRLG-QPLPSWLRQEL 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	246/492 (50%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	152/258 (59%)
Ndst4	NP_001178778.1	HSNSD	20..505	CDD:403326	246/492 (50%)
Ndst4	NP_001178778.1	Sulfotransfer_1	594..845	CDD:395556	154/261 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	527	1.000	Domainoid score	I282
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I279
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm46066
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	LDO	PTHR10605
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840