DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sfl and NDST1

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001534.1	Gene:	NDST1 / 3340	HGNCID:	7680	Length:	882	Species:	Homo sapiens

Alignment Length:	906	Identity:	476/906 - (52%)
Similarity:	632/906 - (69%)	Gaps:	56/906 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 IARRCFGINVRRCVLALLAITMVSIFYYTHYV----------------DTGVFNGLIQRDTHPAP 209
            :.|.|..::.:..:..|....:.|:|...:|:                |.|          .|.|
Human     7 LRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCG----------DPPP 61

  Fly   210 IINCRMINSGGKHIRNASPAPDHRSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEV 274
            :...|::..  |.::.|:|:         |.||.||||||:.||.||:::..:|..:|.||:.|:
Human    62 VAPSRLLPL--KPVQAATPS---------RTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEI 115

  Fly   275 A-GK-SLPVLTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGA 337
            | || .:|.||:..:||:.:|::||:.||:|:|.||||||||||..|.|||:||...:|.:|:.|
Human   116 APGKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSA 180

  Fly   338 QLRDFPLFVNTNLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQ-RN 401
            ||:.||||:::||.|:|.|:||.|.:|.:||..|...|.|||:||.|||.||||||||..|: |:
Human   181 QLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRS 245

  Fly   402 TQEYP---ADSVGQVQLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLN 463
            ::..|   ||:.....|. .||:||.|..|||||||||::|.||||:|||:||:::|:..:|||.
Human   246 SESIPHLGADAGLHAALH-ATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLP 309

  Fly   464 LERMILVDIDDIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGD 528
            |:|.|||||||||||::|||::.:||:||..||..:.|.:|.|.||||:|||::|.||..|:.||
Human   310 LDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFNLGYSGKFFHTGTNAEDAGD 374

  Fly   529 DFLLQNVQEFNWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPA 593
            |.||..|:||.||.|||.|.||||:.|.::|..:|.||..|||:|.||||.||:::||||||||.
Human   375 DLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPV 439

  Fly   594 HELLYMAWKKVWNVKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDK 658
            |..||.|||:||:::||||||||||:|||.||||||..|||||||||||||||::.:.||||..:
Human   440 HVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSE 504

  Fly   659 LDESIQGGELFQTIVYNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEM 723
            ||:.|.|||||.|::.|||:|||||:||||:|||.||||:.:::||..||||:|.:.||||||:.
Human   505 LDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQLAQK 569

  Fly   724 YFRLHPEEVDPVWGNPCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNI 788
            ||::..||.||:|.:||:|.|||.||||.|.||..||.|:||||||||||||.||.||..::||.
Human   570 YFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNY 634

  Fly   789 ASPETFEEVQFFNGNNYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPK 853
            .|.|||||:|||||:||::|:||||:|||..|  ||:|.         |.|||||.|||.|..|:
Human   635 PSSETFEEIQFFNGHNYHKGIDWYMEFFPIPS--NTTSD---------FYFEKSANYFDSEVAPR 688

  Fly   854 RSHALLPHAKIVTILISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLN 918
            |:.||||.||::||||:||.||||||||||:|.|.:|..|:|::||||...|...|:.|:||||.
Human   689 RAAALLPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGSDASSKLRALQNRCLV 753

  Fly   919 PGKYAQHLEHWLAYYPAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYC 983
            ||.||.|:|.||:.|.|.|:.::||:.||..|..||:.:|:||.:...:||...|.:|.||||:|
Human   754 PGWYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWC 818

  Fly   984 QAVSEKRNKCLGKSKGRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            |.:...:.|||||||||:||.||..|...|:.||.:||..|.|||.|:| :.:|.||::||
Human   819 QLLEGGKTKCLGKSKGRKYPEMDLDSRAFLKDYYRDHNIELSKLLYKMG-QTLPTWLREDL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	261/511 (51%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	142/258 (55%)
NDST1	NP_001534.1	HSNSD	30..515	CDD:288882	261/506 (52%)
		Heparan sulfate N-deacetylase 1	40..598		309/579 (53%)
		Heparan sulfate N-sulfotransferase 1	599..882		160/292 (55%)
		Sulfotransfer_1	605..855	CDD:279075	144/260 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	524	1.000	Domainoid score	I295
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I296
Isobase	1	0.950	-	0	Normalized mean entropy	S3088
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm41928
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	O	PTHR10605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820