DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and Ndst1

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001335029.1	Gene:	Ndst1 / 15531	MGIID:	104719	Length:	882	Species:	Mus musculus

Alignment Length:	897	Identity:	474/897 - (52%)
Similarity:	630/897 - (70%)	Gaps:	38/897 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 IARRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGL------IQRDT-HPAPIINCRMINS 218
            :.|.|..::.:..:..|....:.|:|...:|: .|...||      .:.|. .|.|:...|::
Mouse     7 LRRLCRHLSPQAVLFLLFVFCLFSVFVSAYYL-YGWNRGLEPSADASESDCGDPPPVAPSRLL-- 68

  Fly   219 GGKHIRNASPAPDHRSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLPV 281
                     |....::.|..|.||.||||||:.||.||:::..:|..:|.||:.|:| || .:|.
Mouse    69 ---------PIKPVQAVAPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPT 124

  Fly   282 LTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFV 346
            ||:..:||:.:|::||:.||:|:|.||||||||||..|.|||:||...:|.:|:.|||:.||||:
Mouse   125 LTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSAQLKGFPLFL 189

  Fly   347 NTNLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQ-RNTQEYP---A 407
            ::||.|:|.|:||.|.:|.:||..|...|.|||:||.|||.||||||||..|: |:::..|   |
Mouse   190 HSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGA 254

  Fly   408 DSVGQVQLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDI 472
            |:.....|. .||:||.|..|||||||||::|.||||:|||:||:::|:..:|||.|:|.|||||
Mouse   255 DAGLHAALH-ATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDI 318

  Fly   473 DDIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQE 537
            ||||||::|||::.:||:||..||..:...:|.|.||||:|||::|.||..|:.|||.||..|:|
Mouse   319 DDIFVGKEGTRMKVEDVKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKE 383

  Fly   538 FNWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWK 602
            |.||.|||.|.||||:.|.::|..:|.||..|||:|.||||.||:::||||||||.|..||.|||
Mouse   384 FWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWK 448

  Fly   603 KVWNVKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGE 667
            :||.::||||||||||:|||.||||||..|||||||||||||||::.:.||||..:||:.|.|||
Mouse   449 QVWGIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSELDKIINGGE 513

  Fly   668 LFQTIVYNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEV 732
            ||.|::.|||:|||||:||||:|||.||||:.:::||..||||:|.:.||||||:.||::..||.
Mouse   514 LFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEK 578

  Fly   733 DPVWGNPCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEV 797
            ||:|.:||:|.|||.||||.|.||..||.|:||||||||||||.||.||..::||..|.|||||:
Mouse   579 DPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEI 643

  Fly   798 QFFNGNNYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHA 862
            |||||:||::|:||||:|||..|  ||:|.         |.|||||.|||.|..|:|:.||||.|
Mouse   644 QFFNGHNYHKGIDWYMEFFPIPS--NTTSD---------FYFEKSANYFDSEVAPRRAAALLPKA 697

  Fly   863 KIVTILISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLE 927
            ||::|||:||.||||||||||:|.|.:|..|:|::||||...|...|:.|:||||.||.||.|:|
Mouse   698 KILSILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGPDASSKLRALQNRCLVPGWYATHIE 762

  Fly   928 HWLAYYPAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNK 992
            .||:.:.|.|:.::||:.||..|..||:.:|:||.:...:||...|.:|.||||:||.:...:.|
Mouse   763 RWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGVTSTVDYHKTLAFDPKKGFWCQLLEGGKTK 827

  Fly   993 CLGKSKGRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            ||||||||:||.||..|...|:.|:.:||..|.|||.|:| :.:|.||::||
Mouse   828 CLGKSKGRKYPEMDLDSRAFLKDYFRDHNIELSKLLYKMG-QTLPTWLREDL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	261/502 (52%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	141/258 (55%)
Ndst1	NP_001335029.1	HSNSD	30..515	CDD:403326	261/497 (53%)
		Heparan sulfate N-deacetylase 1	40..598		309/569 (54%)
		Heparan sulfate N-sulfotransferase 1	599..882		158/292 (54%)
		Sulfotransfer_1	605..855	CDD:395556	142/260 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	527	1.000	Domainoid score	I295
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1004	1.000	Inparanoid score	I292
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm43976
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	O	PTHR10605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870