DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and ndst3

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	XP_009305879.1	Gene:	ndst3 / 100317129	ZFINID:	ZDB-GENE-090312-199	Length:	874	Species:	Danio rerio

Alignment Length:	890	Identity:	488/890 - (54%)
Similarity:	620/890 - (69%)	Gaps:	43/890 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 NVRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINCRMINSGGKHIRNASPAPDHR 233
            |:||.|:.|....|||:....:|:.||....|...|....|  :|..:.:          .|..:
Zfish    10 NLRRLVILLATFCMVSVLISAYYLYTGSTQELDLADRAIGP--DCADLRA----------LPFRQ 62

  Fly   234 SEARL-------RIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK-SLPVLTNLDKGR 289
            ||.|.       |.||.||||||:.||.||:||..:|..|:.:|..|:| || .:|.||:..:||
Zfish    63 SELRTPKPIDPSRKDPVVLVFVESQYSQLGQDIIAILESNQFRYHAEIAPGKGDIPPLTHKGRGR 127

  Fly   290 YGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNTNLRLRD 354
            |.::::|||.||:.||.|||:||||||.|||||::.|...||.:....|||.|||.:.||:.|||
Zfish   128 YALVIYENLLKYVGMDAWNRDLLDKYCAEYSVGVIAFHRASENSQPALQLRGFPLTLRTNVALRD 192

  Fly   355 ASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPADSVGQVQLP--- 416
            ..:||.|.:|.:||| |...|.|||:||.|||.||||||||..|:...:|..|..:    :|
Zfish   193 CCVNPRSPLLYITRA-EVDRGHLPGEDWTVFQFNHSTYEPVLLAKTRPRENGAAQI----IPGPQ 252

  Fly   417 --LTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVGE 479
              ..|::||.|..||:||||||..|.:|||||:.:||:::|:..:||.:|||.|||||||||||:
Zfish   253 GLHATIVQDLGLYDGVQRVLFGHGLNYWLHRLILVDAIAFLTGRKLSRSLERYILVDIDDIFVGK 317

  Fly   480 KGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSHM 544
            ||||:..:||:||:.||..:.:.|..|.||||||||::|.||:||:.|||.||:.|.||.||.||
Zfish   318 KGTRMNVNDVKALLETQNTLRSYVSNFTFNLGFSGKFFHTGTQEEDDGDDLLLKYVDEFWWFPHM 382

  Fly   545 WKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVKV 609
            |.|.||||:.|.:.||.:|.||..||::|.||.|.||:::||||||||.|..||.||||.|.::|
Zfish   383 WSHMQPHLFHNESSLMEQMILNKDFALEHGIPVDLGYAVAPHHSGVYPVHIQLYEAWKKAWGIQV 447

  Fly   610 TSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIVY 674
            |||||||||:|||.|:||||.||||||||||||||||::...||||..:||:||:|||||.|::.
Zfish   448 TSTEEYPHLKPARHRKGFIHNNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIRGGELFLTVLL 512

  Fly   675 NPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGNP 739
            |||:|||||:||||:|||.||||.::..||:|||||:|.:.||:|||..||.|.||:.:|:|.||
Zfish   513 NPISIFMTHLSNYGNDRLGLYTFTNLANFLKCWTNLRLHTLPPLQLAHKYFTLFPEQRNPLWQNP 577

  Fly   740 CDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGNN 804
            |||.|||.||||.|.||.||||:|:|||||||||||.||.||..|:||..|.:|||||||||.||
Zfish   578 CDDKRHKDIWSKEKTCDRLPKFMVVGPQKTGTTALYLFLIMHPFISSNFPSVKTFEEVQFFNTNN 642

  Fly   805 YYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTILI 869
            |::|:||||:|||..|..:|.           |:|||||.||..|..|||:.||||.|||:|:||
Zfish   643 YHKGIDWYMEFFPVPSNVSTD-----------FLFEKSANYFPSEETPKRAAALLPKAKILTLLI 696

  Fly   870 SPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYYP 934
            :|:.||||||||||:|.|..|..:|||:||:|.:.||..|:.|:||||.||.||.|||.||.|||
Zfish   697 NPSDRAYSWYQHQRAHEDPAALQFSFYEVISADNQAPPELRSLQNRCLIPGLYATHLERWLTYYP 761

  Fly   935 AQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSKG 999
            ..||.||||:|||.:|..||:|||:||.:.|..:||..|.:|.:|||:||.:...|.||||||||
Zfish   762 PNQLMIIDGQQLRNDPAKVMDELQKFLGVTPYYNYSQALTFDPQKGFWCQLLEGGRTKCLGKSKG 826

  Fly  1000 RQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDL 1044
            |:|..||..|...|.|||.:.|..|.|||.:|| :|:|.||:::|
Zfish   827 RKYSPMDSESRAFLSRYYRDQNIELSKLLHRLG-QPLPAWLREEL 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	261/503 (52%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	151/258 (59%)
ndst3	XP_009305879.1	HSNSD	20..507	CDD:288882	261/503 (52%)
ndst3	XP_009305879.1	Sulfotransfer_1	596..845	CDD:279075	152/259 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	522	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	975	1.000	Inparanoid score	I298
OMA	1	1.010	-	-		QHG47982
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm24673
orthoMCL	1	0.900	-	-		OOG6_102006
Panther	1	1.100	-	-	LDO	PTHR10605
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.930