DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sfl and ndst2

DIOPT Version :9

Sequence 1:	NP_001163354.1	Gene:	sfl / 38736	FlyBaseID:	FBgn0020251	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001136290.1	Gene:	ndst2 / 100217321	XenbaseID:	XB-GENE-943997	Length:	879	Species:	Xenopus tropicalis

Alignment Length:	904	Identity:	494/904 - (54%)
Similarity:	643/904 - (71%)	Gaps:	36/904 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 MCHCCNLIARRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINC----R 214
            |.|...|: |....:.:.|.:|.|:|.::.|:.:..:||.    |....::..|.|..:|    |
Frog     1 MIHLWKLV-RHMRQLELHRLILLLIAFSLASMCFLAYYVT----NSPKIKEPPPLPFSDCSSQQR 60

  Fly   215 MINSGGKHIRNASPAPDHRSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA-GK- 277
            .:.......|.|......|:|      |.||||||:.||.||::|..:|...|.||:.|:| ||
Frog    61 TVVQPQASWRIAKSVDTSRTE------PVVLVFVESIYSQLGQEIVAILESGRFKYRTEIAPGKG 119

  Fly   278 SLPVLTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDF 342
            .:|.||:.|:|||.:|::||:.||:|:|.||||||||||.||.|||:||...:|.:|:.|||:.|
Frog   120 DMPTLTDKDRGRYALIIYENILKYVNLDAWNRELLDKYCVEYGVGIIGFFKANENSLLSAQLKGF 184

  Fly   343 PLFVNTNLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPA 407
            |||:::||.|||..:||.:.:|.:|||.|...|.||||||.|||.||||||||..|...:    |
Frog   185 PLFLHSNLGLRDYHINPNAPLLYVTRANEVEQGPLPGDDWTVFQSNHSTYEPVLLASTKS----A 245

  Fly   408 DSVGQV---QLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMIL 469
            :|:..:   :....||:||.|..|||||||||::|.||||:|:|:||::||:..:|.|.|:|.:|
Frog   246 ESIPHLATHKALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLIFVDAIAYLTGKRLCLTLDRYVL 310

  Fly   470 VDIDDIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQN 534
            |||||||||::|||::..||.||:.||..:..:||.|.||||||||:||.||.||:.|||.||.:
Frog   311 VDIDDIFVGKEGTRMKVSDVEALLNTQSKLRTLVPNFTFNLGFSGKFYHTGTDEEDEGDDMLLLH 375

  Fly   535 VQEFNWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYM 599
            .:||.||.|||.|.||||:.|:|:|..:|.||..||.:|.||.|.||:::||||||||.|..||.
Frog   376 RKEFWWFPHMWSHMQPHLFHNVTVLAEQMKLNKQFAQEHGIPIDLGYAVAPHHSGVYPIHSQLYE 440

  Fly   600 AWKKVWNVKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQ 664
            |||.|||::||||||||||||||.||||||.||||||||||||||||::.:.||||..:||:||:
Frog   441 AWKSVWNIQVTSTEEYPHLRPARFRRGFIHNNIMVLPRQTCGLFTHTIFYNEYPGGSKELDKSIR 505

  Fly   665 GGELFQTIVYNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHP 729
            |||||.|::.|||:|||||:||||:|||.||||:|::||:||||||:|.:.||||||:.||.:.|
Frog   506 GGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVKFVQCWTNLRLQTLPPVQLAKKYFEIFP 570

  Fly   730 EEVDPVWGNPCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETF 794
            ||.:|:|.|||||.|||.||||.|.||.||||||:|||||||||||||||||.::.||..||.||
Frog   571 EEKNPLWQNPCDDKRHKDIWSKEKTCDRLPKFLVVGPQKTGTTALYTFLSMHPAVTSNFQSPVTF 635

  Fly   795 EEVQFFNGNNYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALL 859
            ||:|||||.||::|:|||||||          |||:. .|..|||||||.|||.|.||||:.|||
Frog   636 EEIQFFNGINYHKGIDWYMDFF----------PMPSN-ASTDFMFEKSANYFDSEMVPKRAAALL 689

  Fly   860 PHAKIVTILISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQ 924
            |.||::.:||:||.||||||||||:|.|.:|.||:|.||:.|..:||..|::|:||||.||.||.
Frog   690 PRAKVIAVLINPADRAYSWYQHQRAHNDPVALNYTFAQVVYAGLNAPLELRNLQNRCLMPGWYAV 754

  Fly   925 HLEHWLAYYPAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEK 989
            ||:.||||:||.|:||:||::||.:|...|:.:|:||.:.|..:|:..|::|..|||:||.....
Frog   755 HLDRWLAYFPANQVHIVDGQELRSDPATAMDSIQKFLGVTPHFNYTQALKFDEAKGFWCQLADNG 819

  Fly   990 RNKCLGKSKGRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDLSTGT 1048
            :.|||||||||:||.|::.|...|...:..:|..|.|||.:|| .|:|.||::.|...:
Frog   820 KTKCLGKSKGRKYPDMEQSSRTFLTDLFRENNIELSKLLNRLG-HPLPTWLREVLQNSS 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sfl	NP_001163354.1	HSNSD	179..669	CDD:288882	266/498 (53%)
sfl	NP_001163354.1	Sulfotransfer_1	758..1017	CDD:279075	149/258 (58%)
ndst2	NP_001136290.1	HSNSD	26..510	CDD:371875	265/497 (53%)
ndst2	NP_001136290.1	Sulfotransfer_1	599..850	CDD:366246	149/261 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	534	1.000	Domainoid score	I279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20803
Inparanoid	1	1.050	1012	1.000	Inparanoid score	I289
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190899at33208
OrthoFinder	1	1.000	-	-		FOG0000762
OrthoInspector	1	1.000	-	-		otm49151
Panther	1	1.100	-	-	O	PTHR10605
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4681
SonicParanoid	1	1.000	-	-		X450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190