Protein Alignment Vps8 and vps8

DIOPT Version :10

• Sequence 1: NP_648048.1
• Gene: Vps8 / 38735
• FlyBaseID: FBgn0035704
• Length: 1229
• Species: Drosophila melanogaster
• Sequence 2: XP_012826327.1
• Gene: vps8 / 100127670
• XenbaseID: XB-GENE-988494
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 1324
• Identity: 404/1324 - (30%)
• Similarity: 685/1324 - (51%)
• Gaps: 196/1324 - (14%)

  Fly    21 DSLLAESLQLDFED---------LDDAEFAIPPTDVLPTLEAVLSEFEADSDVASEFGMPVP--- 73
            |.|.....:|.|.|         :||.||.||..|..||||::|:|    :|...|..:|..
 Frog    50 DDLNRSQSRLGFLDMDKEAKQDLIDDKEFDIPQVDTPPTLESILNE----TDDEEESFIPEDPAL 110

  Fly    74 --------HATPTPSI-GEDSTIRT--------DGRGGGGSIMRYTLLHGISAQLSSAAERVNAG 121
                    |:..|.|: ..||..|.        |.....||:|.::||.|||||:.|||::|:||
 Frog   111 LNVEAIDVHSCDTSSLASSDSGDRVHKRKKKLPDAFSRHGSVMHHSLLKGISAQIVSAADKVDAG 175

  Fly   122 AASSCAVAAFIAIGTSHGHILNF--DVTQTLRWAHQDKHGQ-------GAVASLAFNADSTRLLA 177
            ..::.||:..||:|||||..|.|  |..|.:|..    .|.       |||::|:.|:|.:|||.
 Frog   176 LPTAIAVSNLIAVGTSHGLALIFGKDTNQAMRLC----LGSTAVGAQYGAVSALSINSDCSRLLC 236

  Fly   178 GFSRGLVAMLDTHTGDVLRELFDVITPNTGVLHVKWTSRSSLALCADAGGSVWSLSFTRKLGIRG 242
            ||::|.:.|.|...|.:||.:.|...|.|.:||:|:|...:||:|.|:||||:.|:|.|.:|:|.
 Frog   237 GFAKGQITMWDLAGGKLLRTITDAHPPGTAILHIKFTDDPTLAVCNDSGGSVFELTFKRVMGVRT 301

  Fly   243 CQSRCLFSGARGEVCAVEPLIMDSQGR-HELDQYCIVALATLSKYFIVTVRPRLRV-IKYHVLQG 305
            |:|||||||::||||.:|||...::.| |.:..|.::|:|:|:|..::.::|.|:| :.:...:.
 Frog   302 CESRCLFSGSKGEVCCIEPLHTKAELRDHPITHYSLLAMASLTKILVIGLKPSLKVWMTFPYGRM 366

  Fly   306 PPDCLPLLAWHLVLIQAADTSRSVDPVIVVGRGNQLFFHQLFV---SNGRITLLYLRHVQLQGSL 367
            .|..:||||||.|::|.|     ::|::...||:.:  |.|.|   .:|.|.:...:.:.|...|
 Frog   367 DPSSVPLLAWHFVILQGA-----LNPMLAFCRGDVV--HFLLVKRDDSGAIHINKQKQLHLHYDL 424

  Fly   368 LSAHWLGPKCVASLDTAEILHLVDVRSSKELECMDMANAGLVYGSAQFKGLATGGNVSPAFALAG 432
            ::..|:..:.||.||:||.||::|.::.:|||.:::::..|||.|:.||.||||||||.|.|..|
 Frog   425 INFTWINARTVALLDSAEKLHVIDRQTQEELETLEISDVQLVYNSSHFKSLATGGNVSQALAFVG 489

  Fly   433 SNACYNSVVSRGTQLYVLGARSLHIIGVRTWSERISFLVKHHRWQEACQLAL---DGYIASV--- 491
            ..|||.|:.|.|.|::.||.:|:|.:.:|.|.||:..|:|...:.||..||.   :|...:|
 Frog   490 EKACYESISSYGGQIFYLGTKSVHAMTLRNWRERVDHLLKQDCYNEALALAWSFHEGKAKAVVGL 554

  Fly   492 --DRPRKRAQAKERIIMLFKEYIANSAR-APE--------------------YCLGAIVNCLITV 533
              |..::::...::|:.:..:|...:.| .||                    |||        .:
 Frog   555 SGDPKKRKSVVADKIVEILLQYTEKALRKCPEQGKIQVMEQHFQDTVPLMVDYCL--------LL 611

  Fly   534 GELDLLWTQLWEKLHNS--STELFLQHISEHIEKETIHSVNP-VISQALVDYWLEHSPAKLEQLI 595
            ...|:|::|:::||..:  :..:||:.:..::.::.:..:.. |:...|:.:..:.....:|..|
 Frog   612 QRTDILFSQMYDKLSENCVAKGVFLECLEPYLLRDQLPGLTAHVMKDLLLHFQDQGQMESVEACI 676

  Fly   596 LKLDWMCLDLNQVLKAVKKHRLFRAQIYLNTQALNDYTAALTELL-----PL-----VTPDETDL 650
            :.:|...||:..::....:|||:.|.||:..:..||:.:.:.:|.     |:     :|.::..:
 Frog   677 VHMDITSLDIQNIVHMCWEHRLYDAVIYVYNKGTNDFISPMEKLFNAISAPINSGKSLTDEQVVM 741

  Fly   651 GNCLLVYVSSCLAGREYPSGEIPVELVHQVKHDVLRCLTSQHSKENAGDELPYPYLRALLKFDTR 715
            ||.||||:||.||||.||.|:||.:||..||:.|...|...||.|...:|..|||:|.||.||||
 Frog   742 GNKLLVYISSSLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSPETPQEEEVYPYIRTLLHFDTR 806

  Fly   716 ETLNVISLAFQEREFSNE-LGISHRKRIINLLLEIMSPENA--TWAEIGCLLNFIAQQISM--QC 775
            |.|||::|.|:  :|:|: ..:.|::||:::||::| .||:  |.:::|||..|:|:|::.  ..
 Frog   807 EFLNVLALTFE--DFTNDKQAVEHQQRIVDILLKVM-VENSDFTPSQVGCLFTFLARQLAKPDNT 868

  Fly   776 LPRDRQLLERVLSHLAQEEIANESSRQHSERENAWHELLSSNCLAEISSDEEQLRLAEKAKCYCV 840
            |..:|.|.::||..|...:   :.|| ||||:....|||.:..:.:. .:...::|||:|:.|.:
 Frog   869 LFVNRMLFDQVLEFLCSPD---DDSR-HSERQQVLLELLHAGGVVQF-EENRLIQLAERAQFYQI 928

  Fly   841 VEYLLEKLERYDTILDSYIRNEARHETMFAYMERHVASP------KRSIFRQLKRNLRELLTINA 899
            .|::.|:..:||.|:|.|:::..|.:.:|.|:...::.|      |.:.:.:..:::.||:.:..
 Frog   929 CEFMYERKHQYDKIIDCYMQDPIRKQDVFNYIHNILSIPGYSAEEKEATWDKTMQHMEELILLCP 993

  Fly   900 KETTRLLSLHYPEKINELLDNLRREENLLYL-FLKCLNDRKSELEASQ---------MELLLELY 954
            .:...|:..|:...:.:::..|:  :.||.| ||:.|.|.:.....:.         .||.::|.
 Frog   994 SKAADLVCTHFSSHLEDVIGKLK--DPLLVLQFLRSLLDPRDGAHVTPEVLQTLPHITELFIDLM 1056

  Fly   955 CKMESSSTVEEFLRSNSGYRLENAIAIAESHHLNRSVIYLYEKQESYAKAFELSM----ELLKSA 1015
            .:.:... |...|:....||||..|.||:.|:.:.::.||.||:.....||.:.:    |.|.:.
 Frog  1057 YQNDPEQ-VAPLLQILEHYRLEETIQIAQRHNHHETLAYLLEKKGDVEAAFRVMLMRLQERLSNL 1120

  Fly  1016 AGEEA-------------AKEAQTISALLA-RSVETLPAQELERCWFALLQYILPHQE------- 1059
            ..:..             .:|..|.:.||. |:.:||..|:.|..||.||:.::..|:
 Frog  1121 TSDSVDSPSFKVMPNMKDLEETLTETILLCERTSDTLNQQQREALWFPLLEAMMSPQKHFTSSSA 1185

  Fly  1060 ------LQSITKSLLHEASQHIDLHNLVQLIMNTHNVSTSFG-----DIKDLLMGMLDSSRHKTE 1113
                  |:::|..:|:..:.:|.|.:::|.|:.    ...:|     :|:.|::||||:..::..
 Frog  1186 QMYSESLKTLTMQVLNSMATYISLPSILQRILQ----DPVYGKGKLVEIQGLVLGMLDTFNYEQT 1246

  Fly  1114 ALRASAGALCQDLHLKFVKRYQHAHRGLWVTTTKCSMC------RQRLYDHSQVLIFGGCGHGIH 1172
            .|..:...|.||||...........|.|......|.:|      ||...|  ::::| .|||..|
 Frog  1247 LLETTTNLLNQDLHWSLCNLKASVTRALVPKQDYCCVCLQQYKRRQEATD--EIIVF-SCGHLYH 1308

  Fly  1173 EQCMEESETQFEE-------CPRC 1189
            ..|:...:.:.|.       |.||
 Frog  1309 SLCLLGKDCKVEVGGQSQWICHRC 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps8	NP_648048.1	WD40	6..>259	CDD:441893	108/275 (39%)
		WD40 repeat	123..156	CDD:293791	14/34 (41%)
		WD40 repeat	164..199	CDD:293791	14/34 (41%)
		WD40 repeat	208..241	CDD:293791	16/32 (50%)
		Vps8	554..725	CDD:463718	62/181 (34%)
		Clathrin	905..>1008	CDD:459884	29/112 (26%)
		RING_Ubox	1146..1189	CDD:473075	13/55 (24%)
vps8	XP_012826327.1	WD40	<178..318	CDD:441893	64/143 (45%)
		WD40 repeat	222..259	CDD:293791	15/36 (42%)
		WD40 repeat	268..310	CDD:293791	23/41 (56%)
		Vps8	634..816	CDD:463718	62/181 (34%)
		RING-H2_Vps8	1279..1333	CDD:438348	15/57 (26%)