Protein Alignment CG8270 and Rmc1

DIOPT Version :9

• Sequence 1: NP_648047.2
• Gene: CG8270 / 38734
• FlyBaseID: FBgn0035703
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_083899.1
• Gene: Rmc1 / 76482
• MGIID: 1916528
• Length: 657
• Species: Mus musculus
• Alignment Length: 660
• Identity: 240/660 - (36%)
• Similarity: 385/660 - (58%)
• Gaps: 55/660 - (8%)

  Fly     8 HYIELTPNPIRFDAVSQLTNVFFDDSNKQIFAVRSGGATGVVVKGPGSPDDVVISFCMSDRGGAI 72
            :|:||...|::|:..:.:..||||::|||:||||||||||||||||  .|...|||.|.|| |.:
Mouse     6 YYLELCERPVQFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGP--DDRNPISFRMDDR-GEV 67

  Fly    73 RSIKFSPDNQILAVQRKENSVEFICFQGDQPLLQDIITHQVKTL---IHGFVWVHNREVALISNT 134
            :.||||.:|:||||||...:|:|..|..|...|:  .|.:.||.   |.||.|..:.|:..|::.
Mouse    68 KCIKFSLENKILAVQRTAKAVDFCNFIPDNSQLE--YTQECKTKNANILGFCWTSSTEIVFITDQ 130

  Fly   135 GVEVYTVVPEKRQVRSVKSLSIGIKWFAWCCDANVALLCTSE-GNSLIPVLVKQKVITKLPKVDL 198
            |:|.|.|:||||.::.:||.:|.:.|:.:|.::.|.||.|:. .|.|.|...:...::||||.::
Mouse   131 GIEFYQVMPEKRSLKLLKSHNINVNWYTYCPESAVILLSTTVLENVLQPFHFRAGTMSKLPKFEI 195

  Fly   199 GNPSR------DVQESKVTLGQVYGVLAVLILQ-----SNSTTGLMEVEVHLLNGPGLAPRKCHV 252
            ..|:.      .:.|..:.:..:||.|.:|.|:     ||||..  ||.::.|...| |.:|.|:
Mouse   196 ELPAAPKSTKLSLSERDIAMATIYGQLYILFLRHHSRTSNSTGA--EVVLYHLPREG-ACKKMHI 257

  Fly   253 LRLSLLGRFAINTVDNLIVVHHQASGTSLLFDISLPGEVINEITYHTPITPGRSIKPFGLKL--P 315
            |:|:..|:||:|.||||:|||||.:.||::|||.|.||....:|:|.|:.|.|||:|:.:.|  |
Mouse   258 LKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIRLRGEFDGTVTFHHPVLPARSIQPYEIPLAGP 322

  Fly   316 SLSPDGQILQCELYSTHWVLFQPNIVIDAKLGCMWFLNLCIEPLCQLISDRIRLTEFLLQRSNGK 380
            :.......:.|:|||:.|::|||:|:|.|..|.:|.|.:.::|:..|:.|:.||.:|||||...|
Mouse   323 AAVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLQPIVNLLPDKGRLMDFLLQRKECK 387

  Fly   381 QMLLKVIGQLVDDQYKGTLLPVLETIFSRINKIYASWVQLELQNQTAQPSNVKTTTLKQSTPPI- 444
            .::|.|..|::.:..:.| |||:.|:|.::|..|..::..:.....|..:.     ..:|.||:
Mouse   388 AVVLSVCSQMLSESDRAT-LPVIATVFDKLNHEYKKYLDADQSYTMAVEAG-----QSRSNPPLK 446

  Fly   445 ------VLIEQLDM-VQIFQRIARRPYTE----------SILMLYLQSLNKFNIAAQEELSKMII 492
                  .:::|.|: .|:..     |:.|          ::||.|::|||:|.|..|..|.:::|
Mouse   447 RPVRTQAVVDQSDVYTQVLS-----PFVENKEMPHKFVIAVLMEYIRSLNQFQIPVQHYLHELVI 506

  Fly   493 SELISNRSFDTLRRLVSYSMLLESKSVACFLLSHSNVDTAISQVAIDMLGRIE-AHEIIIEVMLG 556
            ..|:.:..|..|.:.:.|.:|.:||.:||.|||..:......|:::|||.|:. |::.|:||:|.
Mouse   507 KTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLS 571

  Fly   557 QGKVIDALRLAKNSMGLEKVPARKFLEAAHKTKDDLIFHSVYRFFQMRNLKLYETLSFPKAEQCT 621
            :.:|:.|||..:...|.:.:.|||||:||.:|.|.::|::::|||:.||.:|....:|...|.|.
Mouse   572 KHQVLAALRFIRGIGGHDNISARKFLDAARQTDDVMLFYTIFRFFEQRNQRLRGNPNFTPGEHCE 636

  Fly   622 EFIQHYNNTF 631
            |.:..:...|
Mouse   637 EHVAFFKQVF 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8270	NP_648047.2	Mic1	461..616	CDD:284457	57/165 (35%)
Rmc1	NP_083899.1	Mic1	475..631	CDD:284457	55/155 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850382
Domainoid	1	1.000	300	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG2377
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8341
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1903
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59981
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006644
OrthoInspector	1	1.000	-	-		oto94235
orthoMCL	1	0.900	-	-		OOG6_104796
Panther	1	1.100	-	-	LDO	PTHR12897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4196
SonicParanoid	1	1.000	-	-		X5651
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790