DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8270 and RMC1

DIOPT Version :9

Sequence 1:	NP_648047.2	Gene:	CG8270 / 38734	FlyBaseID:	FBgn0035703	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_037458.3	Gene:	RMC1 / 29919	HGNCID:	24326	Length:	657	Species:	Homo sapiens

Alignment Length:	663	Identity:	242/663 - (36%)
Similarity:	392/663 - (59%)	Gaps:	40/663 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HYIELTPNPIRFDAVSQLTNVFFDDSNKQIFAVRSGGATGVVVKGPGSPDDVVISFCMSDRGGAI 72
            :|:||...|::|:..:.:..||||::|||:||||||||||||||||  .|...|||.|.|: |.:
Human     6 YYLELCERPVQFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGP--DDRNPISFRMDDK-GEV 67

  Fly    73 RSIKFSPDNQILAVQRKENSVEFICFQGDQPLLQDIITHQVKTL---IHGFVWVHNREVALISNT 134
            :.||||.:|:||||||...:|:|..|..|...|:  .|.:.||.   |.||.|..:.|:..|::.
Human    68 KCIKFSLENKILAVQRTSKTVDFCNFIPDNSQLE--YTQECKTKNANILGFCWTSSTEIVFITDQ 130

  Fly   135 GVEVYTVVPEKRQVRSVKSLSIGIKWFAWCCDANVALLCTSE-GNSLIPVLVKQKVITKLPKVDL 198
            |:|.|.|:||||.::.:||.::.:.|:.:|.::.|.||.|:. .|.|.|...:...::||||.::
Human   131 GIEFYQVLPEKRSLKLLKSHNLNVNWYMYCPESAVILLSTTVLENVLQPFHFRAGTMSKLPKFEI 195

  Fly   199 GNPSR------DVQESKVTLGQVYGVLAVLILQ-----SNSTTGLMEVEVHLLNGPGLAPRKCHV 252
            ..|:.      .:.|..:.:..:||.|.||.|:     ||||..  ||.::.|...| |.:|.|:
Human   196 ELPAAPKSTKPSLSERDIAMATIYGQLYVLFLRHHSRTSNSTGA--EVVLYHLPREG-ACKKMHI 257

  Fly   253 LRLSLLGRFAINTVDNLIVVHHQASGTSLLFDISLPGEVINEITYHTPITPGRSIKPFGLKLPSL 317
            |:|:..|:||:|.||||:|||||.:.||::|||.|.||....:|:|.|:.|.|||:|:  ::|..
Human   258 LKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIKLRGEFDGSVTFHHPVLPARSIQPY--QIPIT 320

  Fly   318 SPDGQILQ----CELYSTHWVLFQPNIVIDAKLGCMWFLNLCIEPLCQLISDRIRLTEFLLQRSN 378
            .|.....|    |:|||:.|::|||:|:|.|..|.:|.|.:.:||:..|:.|:.||.:|||||..
Human   321 GPAAVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLEPIVNLLPDKGRLMDFLLQRKE 385

  Fly   379 GKQMLLKVIGQLVDDQYKGTLLPVLETIFSRINKIYASWVQLELQNQTAQPSNVKTTT--LKQST 441
            .|.::|.|..|::.:..:.: |||:.|:|.::|..|..::..|.....|..:....::  ||:..
Human   386 CKMVILSVCSQMLSESDRAS-LPVIATVFDKLNHEYKKYLDAEQSYAMAVEAGQSRSSPLLKRPV 449

  Fly   442 PPIVLIEQLD----MVQIFQRIARRP--YTESILMLYLQSLNKFNIAAQEELSKMIISELISNRS 500
            ....:::|.|    ::..|......|  :..::||.|::|||:|.||.|..|.:::|..|:.:..
Human   450 RTQAVLDQSDVYTHVLSAFVEKKEMPHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNL 514

  Fly   501 FDTLRRLVSYSMLLESKSVACFLLSHSNVDTAISQVAIDMLGRIE-AHEIIIEVMLGQGKVIDAL 564
            |..|.:.:.|.:|.:||.:||.|||..:......|:::|||.|:. |::.|:||:|.:.:|:.||
Human   515 FYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAAL 579

  Fly   565 RLAKNSMGLEKVPARKFLEAAHKTKDDLIFHSVYRFFQMRNLKLYETLSFPKAEQCTEFIQHYNN 629
            |..:...|.:.:.|||||:||.:|:|:::|::::|||:.||.:|..:.:|...|.|.|.:..:..
Human   580 RFIRGIGGHDNISARKFLDAAKQTEDNMLFYTIFRFFEQRNQRLRGSPNFTPGEHCEEHVAFFKQ 644

  Fly   630 TFPADNPTRQPVS 642
            .| .|....:|.:
Human   645 IF-GDQALMRPTT 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8270	NP_648047.2	Mic1	461..616	CDD:284457	57/157 (36%)
RMC1	NP_037458.3	Mic1	475..631	CDD:284457	57/155 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160012
Domainoid	1	1.000	300	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG2377
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8341
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1889
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59981
OrthoDB	1	1.010	-	-		D191938at33208
OrthoFinder	1	1.000	-	-		FOG0006644
OrthoInspector	1	1.000	-	-		oto90645
orthoMCL	1	0.900	-	-		OOG6_104796
Panther	1	1.100	-	-	LDO	PTHR12897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4196
SonicParanoid	1	1.000	-	-		X5651
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800